Bill Li

@harvardmitmdphd student working with @ZhuangLab

[Yosuke Tanigawa @yk_tani]

I’m happy to share our latest preprint, led by Xiaohe (Lucy) Tian.

We showed that ancestry-aware integration of tissue-specific genomic annotations enhances the transferability of polygenic scores.

More in 🧵

[Bill Li @williamfanli]

@zwniu @arjunrajlab @CellSystemsCP @O_Farrell_Aoife @jess_ljx @SamReffsin @uffdaALLberries @IanDardani Congrats William!

[bioRxiv Genetics @biorxiv_genetic]

PRISM: ancestry-aware integration of tissue-specific genomic annotations enhances the transferability of polygenic scores https://t.co/nbjGSDmXd6 #biorxiv_genetic

[Xiaohe (Lucy) Tian @xiaohetian89]

Excited to share that our new preprint is now live on bioRxiv!

📄 Title: PRISM: ancestry-aware integration of tissue-specific genomic annotations enhances the transferability of polygenic scores
🔗 Link: https://t.co/ViudwxyzDR

In this work, we introduce Priors-informed Regression for Inclusive Score Modeling (PRISM), a transfer-learning framework that integrates ancestry- and tissue-specific variant-level annotations to improve polygenic score transferability, achieving up to a 36.5% increase in predictive performance (R²) in the African-ancestry UK Biobank participants.

Huge thanks to the co-authors for making this work possible.

I’m especially grateful to our corresponding authors, @manoliskellis & @yk_tani, for their invaluable guidance throughout the process.

We’d love to hear your thoughts and feedback!

[Bill Li @williamfanli]

@roques_carmes @MIT Congratulations!

[Bill Li @williamfanli]

@Sadagopan_A Congrats, Ananthan!

[Bill Li @williamfanli]

@nasun818 @WhiteheadInst @manoliskellis @MITEECS Congratulations Na!

[Bill Li @williamfanli]

Thank you for hosting such a thoughtful and wonderful conclusion to our white coat day, Loren!

[Loren Walensky @LorenWalensky]

Congratulations to our entering class of MD-PhD trainees @HarvardMITmdphd who received their white coats today! So wonderful to celebrate together with you and your families ♥️ @harvardmed @MIT @NIGMSTraining @NIHAging

[Harvard Medical School @harvardmed]

Today, first year Harvard Medical School and @dental_harvard students mark their transition into the medical profession at the White Coat Ceremony.

Watch the ceremony live at 1:30 p.m. https://t.co/jbjFX5AZnb

[Bill Li @williamfanli]

@roques_carmes @ACSPhotonics Congrats Charles!

[The Harvard/MIT MD-PhD Program @HarvardMITmdphd]

Summer celebrations have begun! We welcomed our entering MD-PhD class at our annual Harvard/MIT MD-PhD program summer barbecue on the quad. A record-breaking crowd of students & faculty enjoyed food, drink & the comradery of this amazing community! @harvardmed @MIT @NIGMSTraining

[Bill Li @williamfanli]

@stephaniehicks @snyquist2 @MITMath @MIT_CSAIL Loved your talk!