Williams Lab

Haematopoiesis and Leukaemia Group that aims to understand and target pathways using novel therapeutic approaches @UCL @DBC_ICH

[Williams Lab @WilliamsLabUCL]

We are even more excited to share @SCantilena’s PhD work!

https://t.co/KuYOZlZ8eZ

As always, amazing work Sandra 🙏
@DBC_ICH

[sandra_cantilena @SCantilena]

Excited to finally share my PhD paper. Our study show that disulfiram target directly the oncogenic MLL-fusion proteins driving acute leukemias. Check it out. @WilliamsLabUCL @DrJasperDeBoer @UCLchildhealth #Leukemia #childhoodleukemia https://t.co/uLCs6DmgeY

[Dr MariaTeresa Esposito @MariaTeresaEs]

Massive thanks to my team, collaborators and funders! @WilliamsLabUCL @BelaPatel_lab @Yolandacalle @menz_mas @lucacozzuto @LeukUK

[Dr MariaTeresa Esposito @MariaTeresaEs]

What is the clinical significance?
#PP2A re-activation già forskolin Is a therapeutic strategy for KMT2A- rearranged #leukemia. Forskolin could be employed to improve the therapeutic index and tolerability of standard #chemotherapy daunorubicin

[Dr MariaTeresa Esposito @MariaTeresaEs]

What does this study add?
A comprehensive characterisation of #PP2A in over 300 AML #leukemia samples, a toxic effect of forskolin in leukemic cells with a repressive effect on C-MYC, HOXA9 and HOXA10 and unanticipated PP2A- independent sensitising activity to #chemotherapy

[Dr MariaTeresa Esposito @MariaTeresaEs]

What is already known?
Previous research identified #PP2A as a therapeutic target for acute myeloid #leukaemia and forskolin as a natural compound with anti-#Cancer effects

[Dr MariaTeresa Esposito @MariaTeresaEs]

Very proud to share the recent results of our @LeukUK funded research Exploiting PP2A dependent and independent effects of forskolin for therapeutic targeting of KMT2A (MLL)‐rearranged acute leukaemia https://t.co/KxDWmWHGkK @UniOfSurrey @BrJPharmacol

[Paolo De Coppi @paolodecoppi]

Great opportunity to understand more on how to use oganoids to study diseases @GerliLab https://t.co/uWSFLiDpOK

[nature @Nature]

A model of a membrane called the blood–brain barrier could transform how scientists study drug delivery to the brain, as well as diseases of the brain’s vascular network https://t.co/Bpd5zp5FJp

[Alejo Rodriguez-Fraticelli @AlejoFraticelli]

🚨🚨🚨🚨
Our new preprint is out!

“Pre-existing stem cell heterogeneity dictates clonal responses to acquisition of cancer driver mutations”
🩸🧫🧪🧬

https://t.co/CYOsKcssPy

The superteam of @cancer_curious and Dani Fernandez tackled a major unanswered question in HSC bio.
1/

[Paolo Gallipoli @PaoloGallipoli]

This week selection of papers in myeloid leukemia biology and therapy is out. Enjoy the vast read and thanks as always @Bims_BiomedNews

Here is the link
https://t.co/5ZPbUVaxCP

[andi roy @andiroy]

U.K. childhood leukaemia researchers- please join us on 19th Sep for the annual meeting- hosted by @Richardson_S_E in Cambridge. Keynote talk by Prof Brian Huntly. Register now!

[Leukaemia UK @LeukUK]

What if we could exploit one of the proteins driving AML? Could we cut off #leukaemia’s energy source and uncover new ways to treat the disease? ⚡

Meet Dr Noelia Che from @ucl, who is using her 2023 John Goldman Fellowship to find out!

👉 https://t.co/BQk56IW3BH

[Williams Lab @WilliamsLabUCL]

Meet our amazing Post-Doc Dr. Noelia Che @noelia_che 👏

[Leukaemia UK @LeukUK]

What if we could exploit one of the proteins driving AML? Could we cut off #leukaemia’s energy source and uncover new ways to treat the disease? ⚡

Meet Dr Noelia Che from @ucl, who is using her 2023 John Goldman Fellowship to find out!

👉 https://t.co/BQk56IW3BH

[Williams Lab @WilliamsLabUCL]

@noelia_che @DBC_ICH @UCLchildhealth Congratulations @noelia_che 👏👏 well deserved

[CLR-UK Network @CLRUKnetwork]

Thanks to session chairs @Richardson_S_E and @WilliamsLabUCL . We missed you @MariaTeresaEs

[JH Klusmann lab @JHKlusmann]

Throwback from #KindPhilipp2023 in #Wilsede looking forward to see you all next year at #KindPhilipp2024

[andi roy @andiroy]

A conference like no other! #KindPhilipp2023 Congratulations to @rolf_marschalek @JhKmann Olaf H and Martin Stanulla for organising such an amazing meeting.

[Jan-Henning Klusmann @JhKmann]

Great to be back in Wilsede. @rolf_marschalek is opening #KindPhilipp2023. We are looking forward to 4 days filled with great science from @Jeremias_lab @florian_grebien @Menendez_Lab @andiroy @ChrBraun02141 @WilliamsLabUCL @Ullrich_Lab @HannahUckelmann and many others.

[UCL Great Ormond Street Institute of Child Health @UCLchildhealth]

Interested in starting a PhD in child health? We have fully funded Child Health research PhD studentships available. Application deadline: 9 January 2023. Find out more: https://t.co/N3oNyAOw1L

@UCLPopHealthSci @DNP_ICH @DBC_ICH @GGM_ICH @ich_ppp @GreatOrmondSt

[Karin Straathof💙🎗 @straathof_karin]

📢Interested in studying the effect of radiation treatment on the #TME and how to combine radio and immune therapies for #childhoodCancer:
Come and join our team @uclcancer
@RadNetCRUKCoL
Don't hesitate to contact me if you want to know more.
https://t.co/pCjm2SsIbk

[andi roy @andiroy]

We have two postdoctoral positions available in our lab, to study #childhoodALL, funded by @NIH and @The_MRC . Join our team in beautiful Oxford @MRC_WIMM @OxPaediatrics @UniofOxford . Link below for more details, and happy to chat!
https://t.co/rXwG7o5tNa