UllrichLab

NK cells, immune cell therapies. From bench to bedside. PI: Prof. Evelyn Ullrich @FCI_health @goetheuni @UK_Frankfurt Tweets: lab members. RT≠endorsements

[UllrichLab @Ullrich_Lab]

Excited to share our #research on #CRISPR-edited #CAR-NK cells @NatureComms. Congratulations to @TobiasBexte, Nawid Albinger and all co-authors 👋This was a great team effort @JHKlusmann @K_Imkeller @FCI_health @goetheuni @UniFreiburg @Krebshilfe_Bonn @DKTK_

[UllrichLab @Ullrich_Lab]

Fantastic #NK cell & #ILC meeting in Lyon 2024 🇫🇷 A big thank you to the organizers @dgfi_org and huge congrats to Alina for the abstract & Tobias for the oral presentation awards🎉and to all awardees and great speakers 2024 @CerwenkaLab @EricVivier1 @MalmbergLab @KathyHsuLab

[Tobias Bexte @🦋bextetobias.bsky.social @TobiasBexte]

Great time at joint 🇫🇷🇩🇪 #NK#ILC meeting in Lyon! Honored to receive an oral presentation award. Fun catching up with old friends from 🇸🇪 🇺🇸 and meeting new ones. Huge thanks for an insightful meeting! Think we all found gold of knowledge at the end of the rainbow! 🐓🌈🧫🧬🍇😉

[Cerwenka Lab @CerwenkaLab]

At NK/ILC meeting in Lyon: congrats to Andi 🏆

[MalmbergLab @MalmbergLab]

A cell intrinsic NKG2A/C switch receptor to overcome the critical HLA-E checkpoint. Fun collaboration with the Michel Sadelain lab. Michelle Sætersmoen, Ivan Kotchetkov, @LambertoTR @CoE_PRIMA @UniOslo_MED @Oslounivsykehus @CIM_Sweden

[UllrichLab @Ullrich_Lab]

The Symposium “Intelligent Oncology – AI to Control Cancer“ was a great success @CRIIONorg #Mertelsmann foundation. Thanks to all speakers and organizers👋 @JulioSaezRod @TomicAdriana @BoerriesLab @Heiko__Becker @GabrielKalweit @Uniklinik_Fr @dgfi_org @dgho_eV @dgimev @Novartis

[UllrichLab @Ullrich_Lab]

Huge congratulations to our successful lab member @TobiasBexte, the whole team @goetheuni @FCI_health and all colleagues contributing to this work #SleepingBeauty #CAR #NK @UniFreiburg @FraunhoferIZI @PEI_Germany @Uni_WUE Big thanks for the award 🏆@DGGTeV

[DG-GT e.V. @DGGTeV]

Congratulations!
The #DGGTeV proudly awards @TobiasBexte representing the @Ullrich_Lab at @goetheuni the #PoQ2024Q2 for harnessing SB-technology for virus-free engineering of primary NK cells to improve their basal anti-cancer function via CAR introduction
https://t.co/tRehIRDi2j

[UllrichLab @Ullrich_Lab]

Honored to participate at ISI-SITC symposium #ECI2024 ‘New Frontiers in Cancer Immunotherapy’ on immune checkpoints @JimAllisonPhD innate and targeted therapy @TobiasBexte @dgfi_org @FCI_health Many thanks to @MichaelodwyerMD @JennGuerriero @JoanneLysaght @EFIS_Immunology

[UllrichLab @Ullrich_Lab]

Amazing first day #ECI2024 with keynote by James P. Allison @JimAllisonPhD followed by a great Irish opening ceremony @EFIS_Immunology @dgfi_org @YI_dgfi @RCSI_Irl @goetheuni

[EFIS @EFIS_Immunology]

🔍 Highlights from Keynote Lecture 1 🔴

No one less than the Nobel Prize Winner 2018, James P. Allison, on immune checkpoint blockade therapy at #ECI2024 🎉

🔑Key points:

💡Anti-CTLA-4 therapy creates a “hot” tumor, which does not happen with anti-PD1 therapy.

🔬Anti-CTLA-4 therapy results in a phenotypical switch inducing ICOS+ Th1-like CD4 T cells. ICOS/ICOSL pathway is necessary for optimal anti-tumor response.

A profound thanks to James P. Allison for his groundbreaking contributions 👏👏

#Immunology #Dublin

[UllrichLab @Ullrich_Lab]

Looking forward to the FCC2024 starting today @FCI_health @goetheuni with an exciting program https://t.co/KmUH4q3aYW

[UllrichLab @Ullrich_Lab]

Delighted to welcome @romeerizwan and thanks for his fantastic presentation on outstanding work in the NK cell field. We had a great scientific exchange at @goetheuni @JhKmann @FCI_health @UK_Frankfurt

[Rizwan Romee @romeerizwan]

I had an amazing time visiting and giving a talk at Frankfurt University ⁦⁦@goetheuni⁩ hosted by ⁦@EvelynNKlab2012⁩ who is doing some cutting edge NK cell work. Also was fun to meet faculty and students there.

[UllrichLab @Ullrich_Lab]

Inspirierendes Summer Networking Event 2024 des FIT-Mentoring Program @goetheuni @UK_Frankfurt ☀️Herzlichen Glückwunsch auch den neuen Fellows des @BMBF_Bund geförderten Advanced Clinican Scientist Programm und des @dfg_public geförderten Clinican Scienist Programms INDEEP!👩‍⚕️🔬

[UllrichLab @Ullrich_Lab]

Exciting work in the field of #NKcells - one should definitely read it! Congratulations to @MalmbergLab and coworkers! 🎉 @herknet @AlinePfefferle @AmirHorowitz et al!

[MalmbergLab @MalmbergLab]

Happy to share our new NK cell resource in @NatImmunol: "Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping." https://t.co/UzENCpFWMv. @herknet, @AlinePfefferle, @AmirHorowitz @humancellatlas, @CoE_PRIMA, @UniOslo_MED

[UllrichLab @Ullrich_Lab]

#NKcell researchers with great scientific collaboration that takes us forward! Congratulations to all colleagues! 🌎🎉

[Eric Vivier @EricVivier1]

Thrilled to announce the publication of our latest research in Nature Immunology. Joining forces with 20 laboratories in Europe and USA, we identified the three prominent NK cell subsets in human: NK1, NK2, and NK3: https://t.co/VMPTPpiLOV

[Goethe-Universität @goetheuni]

Neuer LOEWE-Schwerpunkt "CARISMa" an der #GoetheUniversität zu innovativer Krebstherapie. 👉 https://t.co/2ZZO6VexHY @ProLOEWE @HMWK_Hessen @Uni_MR @FCI_health @PEI_Germany @DKTK_

[UllrichLab @Ullrich_Lab]

Congrats to @lab_rezvani and team on this seminal work towards clinical translation!🎉 So great to see how improved #CAR signaling enhances #NKcell function! 💪

[Katy Rezvani, M.D., Ph.D @lab_rezvani]

Many congratulations to our Dr. Sunil Acharya @sunilacharya13 for his exciting research on CD70-targeting CAR NK cells, published in Cancer Discovery! Sunil and his co-authors showed that the incorporation of CD28 costimulation, which is normally absent in NK cells, in the CAR construct improves efficacy of CAR NK cells via the LCK/CD3ζ/ZAP70 pathway. Sincere thanks to our collaborators for their invaluable contributions. We’re excited about the promising clinical trials ahead! @MDAndersonNews #CancerResearch #Immunotherapy #CAR_NKCells @kchenken @UH_NVLab

[UllrichLab @Ullrich_Lab]

Cutting-edge research environment #KindPhilipp2024! Many thanks to the organizer!!🙏💪Well-deserved talks: EGFR-CAR NKs in solid tumors w/Lisa Marie Reindl, B7-H3-CAR NKs w/Sophia Thul, mechanisms of CAR-NK cancer cell death w/Alina Moter, CD123/CD33-CAR NKs w/Fenja Gierschek!👏

[Jan-Henning Klusmann @JhKmann]

🚀 Kickoff to #KindPhilippMeeting2024. Exciting key lecture by @FlorianHeidel. Packed agenda with cutting-edge research.
https://t.co/RD8I5V63gR

[UllrichLab @Ullrich_Lab]

@pat_n_harter @NeuroOnc @MA_Karreman @LisaSevenich @FCI_health @LMU_Muenchen @Krebshilfe_Bonn Congratulations! We are happy to contribute to this excellent work.

[Tobias Bexte @🦋bextetobias.bsky.social @TobiasBexte]

Paper alert!🧬🎉#SleepingBeauty is awake in primary #NKcells!
So happy to see our work on safe & efficient non-viral CAR NK cells published @MolTherapy! Big shout out to all collaborators especially Zoltán Ivics & all co-authors! https://t.co/MHf67klIbm
@FCI_health @ASGCTherapy🧵

[UllrichLab @Ullrich_Lab]

Excited to go to @C_IMT #CIMT2024 to talk about the concept of CAR-engineered NK cells today, and to see our work on non-viral #SleepingBeauty CAR NKs published! Fantastic work by @TobiasBexte and big thanks to all collaborators! Is the future virus-free?@FCI_health @UK_Frankfurt

[Molecular Therapy Family of Journals @MolTherapy]

Engineering of potent CAR NK cells using non-viral Sleeping Beauty transposition from minimalistic DNA vectors https://t.co/Ry6vnmCCuU #genetherapy #celltherapy