MalmbergLab

The Malmberg Lab studies the functional regulation of natural killer (NK) cells and seeks to employ new insights in NK cell biology in cancer immunotherapy

[MalmbergLab @MalmbergLab]

We will be here: @malmberglab.bsky.social

[MalmbergLab @MalmbergLab]

Great work, congrats. This is where we have to go.

[Katy Rezvani, M.D., Ph.D @lab_rezvani]

Please check out our paper published in @NatureMedicine on our Phase I trial of AFM13-precomplexed cord blood NK cells in relapsed/refractory CD30+ lymphomas. Led by Dr. Yago Nieto and an outstanding team of coauthors and collaborators, this study marks the first clinical demonstration of NK cell redirection using a bispecific engager. We report an ORR of 92.9% and CR of 66.7% in 42 patients with a median of 7 prior therapies and show that this approach is safe and may serve as a bridge to SCT. Excited to move forward with our next generation engineered NK cells in combination with engagers and mAbs. #CancerResearch #Immunotherapy #NKcells @MDAndersonNews

[MalmbergLab @MalmbergLab]

@mkuijjer @iCAN_Finland Good luck with your new adventure. Looks like a very exciting opportunity. We will miss you!

[MalmbergLab @MalmbergLab]

Incredibly impressing ongoing work in the UK NK community. Thanks for the invitation @mjwsim. Looking forward to discussing more NK and KIR work in the coming days and to the yearly double 🎾 with @DrFran_Colucci

[Malcolm Sim @mjwsim]

Wow. What an amazing day. So great to see so much great science about my favourite immune cells. Thanks to everyone who came and especially @MalmbergLab for a stellar keynote.

[MalmbergLab @MalmbergLab]

@hov_jer @ERC_Research @RIIM_UiO_OUS @UniOslo_MED @erc_ncp Congrats Johannes! Sounds like a really cool and important project.

[MalmbergLab @MalmbergLab]

@QuirinHammer @Vetenskapsradet @CIM_Sweden @karolinskainst Congrats Quirin!

[MalmbergLab @MalmbergLab]

Wow, congrats @PN0rmski. Beautiful work!

[Med by Cell Press @MedCellPress]

Online Now: Targeting HLA-E-overexpressing cancers with a NKG2A/C switch receptor https://t.co/V1gsnC1SHX

[GreiffLab 💻🔬💊 @victorgreiff]

We have an open 2-year postdoc position focusing on computational approaches to identify antigen-specific immune receptors from adaptive immune repertoire data. Application deadline: Nov 6. https://t.co/cyIvlclfeU

[MalmbergLab @MalmbergLab]

A cell intrinsic NKG2A/C switch receptor to overcome the critical HLA-E checkpoint. Fun collaboration with the Michel Sadelain lab. Michelle Sætersmoen, Ivan Kotchetkov, @LambertoTR @CoE_PRIMA @UniOslo_MED @Oslounivsykehus @CIM_Sweden

[Med by Cell Press @MedCellPress]

Online Now: Targeting HLA-E-overexpressing cancers with a NKG2A/C switch receptor https://t.co/V1gsnC1SHX

[Katy Rezvani, M.D., Ph.D @lab_rezvani]

Working with a great team including @NathanSinghLab & Stephan Mielke to organize @KeystoneSymp Immune #CellTherapy: Advances in #Cancer and #AutoimmuneDisease

Please join us to explore emerging research in Banff, March 16-19, 2025  | Fairmont Banff Springs, Banff, AB, Canada
Scholarship Deadline: December 9, 2024

Short Talk Abstract Deadline: December 9, 2024
Poster Abstract Deadline: February 20, 2025
Early Registration Deadline: January 28
https://t.co/d40Gn6n6mY #KSCellTherapy25 https://t.co/bO5qLJ8GhF

https://t.co/lp9v81LuO1

[MalmbergLab @MalmbergLab]

Very important and much needed funding to establish ATMP Norway, a multi-nodal national infrastructure for cell and gene therapy. Building on investments in GMP laboratories at @Oslounivsykehus and Haukeland University Hospital and a partnership with @UniOslo_MED.

[Oslounivsykehus @Oslounivsykehus]

Vi er svært glade for tildelingene fra @forskningsradet i dag, som bla. gir midler til å forsette å jobber med celle-genterapi, samt til forprosjekt for protonterapi.
1,3 milliardar kroner til forskingsinfrastruktur (https://t.co/W6OrAHeVF3)

[Waggoner Lab @LabWaggoner]

GPR56 functions as an upstream checkpoint for migration of highly differentiated NK cells @J_Immunol @MalmbergLab @DanielPal88
https://t.co/20s7I0xOwe

[MalmbergLab @MalmbergLab]

Congrats @DanielPal88. Understanding the migratory behavior of NK cells is critical to overcome one of the major bottlenecks in the field: to make NK cells home to solid tumors. The inhibitory GPR56 axis is one piece of the puzzle.

[Daniel Palacios (he/him) @DanielPal88]

Finally it's out and I can share with you all the collaborative effort done to produce this paper! Big thanks to @MalmbergLab and all the people who put so much effort into this. https://t.co/MONEeXusTw

[Malcolm Sim @mjwsim]

Exciting work by @AmirHorowitz and team! Congrats to all.

HLA-E and NKG2A Mediate Resistance to M. bovis BCG Immunotherapy in Non-Muscle-Invasive Bladder Cancer

https://t.co/FuXBYRLi8H

[MalmbergLab @MalmbergLab]

Thanks for this nice and thoughtful commentary of our work. We hope this approach will make a difference in the allogeneic cell therapy space for both T and NK cell based therapies.

[Rizwan Romee @romeerizwan]

Excited to share our commentary on a recent very elegant paper by @MalmbergLab @QuirinHammer and colleagues. A one-way street recognition approach to mediate allogeneic immune cel... https://t.co/R2z8048amJ

[Nature Rev Immunol @NatRevImmunol]

Understanding NK cell heterogeneity https://t.co/8vL7t9ULDY

[Nature Immunology @NatImmunol]

Malmberg and colleagues provide a single-cell transcriptional reference map of healthy human NK cells and use this profile of tumor infiltrating NK cells. Read it here: https://t.co/3lDrHpr1I6
https://t.co/0FnSAvXFuF

[Quirin Hammer @QuirinHammer]

Taken together, in this study in @CellStemCell, we demonstrate that modulating the immune synapse can be a promising strategy to avert rejection by the host and hopefully further unlock 🔓 the potential of next-generation allogeneic #Immunotherapy against #cancer

[MalmbergLab @MalmbergLab]

Comprehensive thread highlighting our most recent work now out in @CellStemCell describing a novel approach to increase persistence of allogeneic cell therapy products. Work led by amazing @QuirinHammer and @KarloPerica. @CoE_PRIMA, @Oslounivsykehus @UniOslo_MED @karolinskainst

[Quirin Hammer @QuirinHammer]

Happy to share the final work from my post-doc with @MalmbergLab published in @CellStemCell today https://t.co/ZcC8Q32kts
extensive 15-post-🧵 below