Malcolm Sim

MRC Career Development Fellow - group leader @UniofOxford. Medical Research Fellow @CorpusOxford. Also on opinions my own

[Malcolm Sim @mjwsim]

Really pleased to see this Opinion Review out.

The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases: Trends in Immunology

https://t.co/7KDDAU9wG7

[Nature Rev Immunol @NatRevImmunol]

Hallmarks and correlates of effective adoptive cell immunotherapy for cancer https://t.co/kQUOnL3uwt

[Malcolm Sim @mjwsim]

Hallmarks and correlates of effective adoptive cell immunotherapy for cancer

https://t.co/OPq99mRmpj

https://t.co/hnG7UBlcx2

[Klebanoff_Lab @KlebanoffLab]

🚨3rd paper in our PI3Ka public neoantigen trilogy is out in @PNASNews! We show that HLA micropolymorphisms govern whether a neoantigen is visible to T cells by tuning neopeptide dynamics, not presentation or static structure. @MSKCancerCenter @parkerici
https://t.co/e8b9JDrQro

[Malcolm Sim @mjwsim]

Congratulations to Ashley on becoming a Fellow of the Royal Society!

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Exceptional scientists elected as Fellows of the Royal Society https://t.co/56yHRIfhbD

[navya b. @navyadotbio]

@ATinyGreenCell

[Malcolm Sim @mjwsim]

‘Using peptide-exchange systems to interrogate peptide-specific KIR binding to HLA Class I’

Our first publication, a method we’ve been working on, and a big milestone for the Sim lab!

https://t.co/znD0QCtfq2

[Dan Davis @dandavis101]

OUT TODAY IN PAPERBACK
IMMUNE HEALTH: A Myth-busting Guide.

‘Will change how you think about your body and live your life’ @DoctorChrisVT
‘Brilliant’ @LizEarleMe
'Beautifully written overview' @ProfBrianCox
'Best book on immune health I have ever read' @theAliceRoberts

[Waggoner Lab @LabWaggoner]

Antibody S22019F Selectively Recognises KIR2DS1 and Enables Analysis of KIR2DS1+ NK Cells and T Cells @QuirinHammer @karolinskainst
https://t.co/GmCSBC9pv7

[Waggoner Lab @LabWaggoner]

A highly efficient nonviral knock-in platform for NK cells, enabling plasmid-based genome editing with up to ∼90% knock-in efficiency and ∼100% recovery
https://t.co/uVG5AI0BOJ
@JExpMed #Felices #Miller @UMNews

[Waggoner Lab @LabWaggoner]

@biorxivpreprint Early-life mucosal T cells direct intestinal stem cell fate via a coordinated developmental program @LizaKonnikova @Yale @madisonstrine
https://t.co/wUxKeuMnKQ

[Nature Biotechnology @NatureBiotech]

Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery https://t.co/sTqSlk47u5

[Waggoner Lab @LabWaggoner]

Whole-protein screening and multi-modal profiling of antigen-specific CD4+ T cells at single-cell resolution
@NatureComms @LabHeath @UW
https://t.co/SLcmlCEdmG

[Malcolm Sim @mjwsim]

Congrats to Julia, Ricardo and the team for this great work. Exciting to see it out in the world!

[Saligrama lab_WUSTL @SaligramaLab]

Well, again -for the lovers of #TCRs and #crossreactivity #Reverse #engineering the fatally #crossreactive #A3A #TCR to decouple potency and #specificity @theRafLab @CAMS_COI_Ox https://t.co/rwUuZKaTAc

[Saligrama lab_WUSTL @SaligramaLab]

Well, again -for the lovers of #TCRs and #crossreactivity #Reverse #engineering the fatally #crossreactive #A3A #TCR to decouple potency and #specificity @theRafLab @CAMS_COI_Ox https://t.co/rwUuZKaTAc

[Malcolm Sim @mjwsim]

I had the pleased hosting the KIR work in Oxford this week. An amazing experience full of great science with new and old friends and colleagues.

[Michael Shafrir @michaelshafrir]

@LocasaleLab My wife was on this trial. Stage 4 panc cancer, 40 years old. She was in this trial and lived 18 months after chemo stopped working. We took trips to Spain, Disney, Jersey Shore. She got two more birthdays with our kids. Shove your hype and misrepresentation up your ass.

[Waggoner Lab @LabWaggoner]

Purification of HLA-G+ Extravillous Trophoblasts from Human Term Placental Tissues for Phenotyping and Functional Analysis @TTilburgs @CincyResearch
https://t.co/wOSltzmO1S

[Waggoner Lab @LabWaggoner]

Mapping the maternal–fetal interface through pregnancy in high resolution @Nature @UCSF
https://t.co/PtQEbEFAbx
https://t.co/flxoXABGVL

[Roberto Vendramin @RobertVendramin]

🚨Paper alert🚨 Very excited to share our manuscript, published today in @ImmunityCP, where we describe how ‘Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome’. (1/16) https://t.co/S58jZLKZ7G

[Waggoner Lab @LabWaggoner]

Circulating and tissue TCRβs associated with lynch syndrome, a genetic condition linked to DNA mismatch repair efficacy and cancer risk @evilarsan @NatureComms @MDAndersonNews
https://t.co/iUWNkU2t74