Fidel Serrano

Postdoc at Brunner group (University of Heidelberg) | Interested in timekeeping mechanisms at the molecular and cellular level | Circadian rhythms

[Fidel Serrano @wthfidel]

P.S. We are fully aware of the limitations of our overexpression approach and have always designed our experiments in a way that they are tightly-controlled. Nevertheless, we think these mechanisms can enrich our understanding of how the circadian repressive phase is organized.⏰

[Fidel Serrano @wthfidel]

1/9 Our publication is now out on eLife! In this study, we became interested in how the circadian repressive phase is organized in circadian time and subcellular space, focusing on the main mammalian circadian repressors: PER2, CRY1, and CK1delta (CK1d). https://t.co/0wX53X56cY

[Fidel Serrano @wthfidel]

9/9 Finally, we saw that only the nuclear pool of CK1d could affect circadian period (cytoplasmic pool having no effect) suggesting that this phosphorylation-mediated disruption of PER2-CRY1 interaction may serve as a transition from the early to the late repressive phase.

[Fidel Serrano @wthfidel]

Our contribution to the circadian field! 🕐
Tweetorial to follow!

[biorxiv_biochem @biorxiv_biochem]

Nuclear CK1δ as a Critical Determinant of PER:CRY Complex Dynamics and Circadian Period https://t.co/fIU5pp9AyE #biorxiv_biochem

[Fidel Serrano @wthfidel]

First time to solve @nytimes Letterboxed in 2 words today! ⚡📈

[Fidel Serrano @wthfidel]

@ayalegre Was looking for dates when we started high school and I literally could not find them + iba na yung section names 🥲

[Greg @GregGrandin]

The social pathology that spawned today’s political hellscape, created and maintained by bipartisan consensus, in one comparative image.

[Heather Hogan @theheatherhogan]

Me: Will you play Running Up That Hill?

Stacy: Are you gonna sing the real lyrics? Or are you gonna do Two Avocados?

Me: Real ones, I swear!

[Alaric @0xAlaric]

Sometimes I think I have a good grasp on some period of history and then I run into a ridiculous piece of information that destroys my entire framing.

For example, Aztecs, samurai, Ottomans, and Spaniards shared the same battlefield… in the Philippines.

[Erik Herzog @ErikHerzog]

We’re looking for post docs! Circadian cancer neuroscience, functional connectomics, developmental sleep and circadian science, your keywords here.

[Society for Research on Biological Rhythms @SRBR_Outreach]

A rallying cry from @MarthaMerrow to chronobiologists worldwide - going further with our new knowledge of properties of circadian clocks to move into practical applications. Read more on #sciencesunday @PlosBiology:

https://t.co/H8GN8Tkmqt

[Extinction Rebellion Hammersmith & Fulham ⌛️ @XR_Hamm_Fulham]

1/12 Here is our very useful series of cards, we handed out to people at @StanChart - everyone was very keen to collect all 12 . We're looking forward to hearing which one was the most useful #ClimateAction

[MPI-CBG Dresden @mpicbg]

We are inviting applications to establish two Research Groups as Max Planck Research Group Leaders (W2) in Cellular Metabolism or Physics of Living Systems. Please apply until November 10th and become part of our community! https://t.co/jh6UrtlefE