Xabier Osteikoetxea

Scientist with a passion for immunology, genetics, extracellular vesicles and their use in cancer therapeutics and diagnostics

[Xabier Osteikoetxea @xabisito]

3- Despite having favourable cardiac function and lower cholesterol levels, PCSK9 KO mice gained much more weight following HFD. This needs more consideration in the context of PCSK9 inhibition strategies. 🧵 (4/4)

[Xabier Osteikoetxea @xabisito]

Thrilled to share the latest work from our group. Studying the same gene therapy targets (PCSK9, LDLR) that we aim to therapeutically edit with Extracellular Vesicles (EVs) we found 3 important messages. 🧵 (1/4) https://t.co/OBswdSxZy5

[Xabier Osteikoetxea @xabisito]

2- High-fat diet (HFD) rapidly increases cholesterol levels but atherosclerotic plaques take much longer to form, only appearing after old age (22-months) but not shorter 12 weeks HFD. There may yet be hope for those of us with bad diets. 🧵 (3/4)

[Xabier Osteikoetxea @xabisito]

@ASEV_Austria Thank you!!

[Xabier Osteikoetxea @xabisito]

Recently I was awarded by the Hungarian Academy of Sciences with the Junior Researcher Award. It is very inspiring, as I was told I am the first non-Hungarian to receive the award and it is a huge motivation to continue working on Extracellular Vesicles https://t.co/2nQJIHr8ov

[Nature Cell Biology @NatureCellBio]

NEW ONLINE: In this Comment, Edit Buzas discusses the roles and biogenesis of the extracellular vesicle (EV) corona & the importance of controls to determine whether a biological effect is attributable to the internal EV cargo or to the EV corona.
https://t.co/Jakv68q6vv

[Edit Buzas @EditBuzas]

Sharing our recent review article on the roles of EVs in the immune system: https://t.co/hyluh6XabY

[Xabier Osteikoetxea @xabisito]

@CFornagueraP @ChemMedChem @IQSbarcelona @uramonllull Muy bien!!

[Xabier Osteikoetxea @xabisito]

This is really interesting and useful, thanks @andregorgens and team!!!

[André Görgens @andregorgens]

Excited to share our now-published @ISEV_JEV paper on Extracellular Vesicle storage conditions! Should be of interest to anyone who stores EV preps, or dilutes EVs, in PBS, even short-term. We identified suitable alternatives.
Please share - thanks! 🧵1/7
https://t.co/tMEOlnEqxP

[Marta Garcia-Contreras @MartaGarciaCon2]

Great time with these amazing EV enthusiasts #ISEV2022 #extracellularvesicles @hps2002 @Exosome_UPLC_MS @amarcilla @xabisito 🟢🔵🔴⚪️🟡🟠🟣

[Xabier Osteikoetxea @xabisito]

@IsevOrg Key takeaways:
-EVs can be used for gene editing
-Big challenge to load Cas9 into EVs but it is possible with inducible protein dimerization
-Gene editing seen in EV-containing SEC fractions and detergent-sensitive
-Cre fluorescent reporters can be used for Cas9 editing detection

[Xabier Osteikoetxea @xabisito]

Our latest paper is out! We found that #EVs #exosomes can be used for #CRISPR gene editing. Thanks to my fantastic colleagues at #AstraZeneca, looking forward to more work together and looking forward to discussing this work at @IsevOrg meeting in Lyon! https://t.co/x2aYXuFFwj

[Xabier Osteikoetxea @xabisito]

So nice to work together with our collaborators in Vienna! @ASEV_Austria @IsevOrg #extracellularvesicles #science

[ASEV - Austrian Society for Extracellular Vesicles @ASEV_Austria]

Remember the Austrian-Hungarian empire? In 2022 not so much "empire", but friendly and constructive talks among #EVenthusiasts, getting together in scientific collaboration 😎🇦🇹🇭🇺 💪

[Xabier Osteikoetxea @xabisito]

@ASEV_Austria So nice to meet you all and so excited for our collaboration!

[Xabier Osteikoetxea @xabisito]

@MartaGarciaCon2 Si 🙂

[Xabier Osteikoetxea @xabisito]

Hungry scientists in Hungary #FCVB2022

[Xabier Osteikoetxea @xabisito]

@MartaGarciaCon2 No, esto fue aquí en Budapest en FCVB

[Xabier Osteikoetxea @xabisito]

Best Christmas Gift from the best lab team members. I am curious who else will understand the message in DNA code... #science #dna #bestteam @ Budapest, Hungary https://t.co/CZtJKlPfUR

[Elisa Lázaro Ibañez @ellzaib]

Excited to share our new article on single-vesicle single-molecule quantification of protein loading into engineered #EVs published in @ISEV_JEV. Thanks @summerdrops21 @xabisito @DrNikkiS @kristina_pagh, @Nano_FCM, @nanoviewbio & @AstraZeneca colleagues https://t.co/OVAPZ7QReN