Alexander Honkala

@OHSUKnight
Contributor @StanfordHIL

Cares about: cancer chemoresistance, human thriving, crazy good ideas

[Alexander Honkala @xhonk]

less interesting to hope that superheating a pile of data in 10 agentic harnesses prints money than it is to ask how sufficiently motivated ppl armed with the glue- and busywork-decimating forces of emerging LLMs can *unbundle* the structural features that the cartels depend on

[Alexander Honkala @xhonk]

no despair allowed as Anthropic & others vaporize LLM wrapper startups in AIxBio, no, categorically not allowed! instead: raise your ambitions, get weirder, fly higher

we're so so so so so so early

[Alexander Honkala @xhonk]

@Ronalfa unfortunately currently reliant on the same HTAN and SMMART data as everyone else

[Alexander Honkala @xhonk]

@Ronalfa this is cool but I'd want to see a comparison of MARS tSNE displacement for a cold->hot treatment to a few human biopsies from same before concluding that it's representing real clinical bio

[Alexander Honkala @xhonk]

wrote up an experiment I put together to try giving MHC-I peptides to agents: https://t.co/69Fm0u1fYW

[Alexander Honkala @xhonk]

Quick thoughts on pharmacodynamic response envelopes and how detangling their components can get us better insight into drug development: https://t.co/6KHDpzedg1

[Alexander Honkala @xhonk]

finally got a chance to read this and the logistics base of 2000 target-to-Phase-2 projects is immense on preclinical & cGMP alone, daunting to think through https://t.co/wI2pAELLko but pushing for fast Phase 0 trials for PD target engagement may help

[Alexander Honkala @xhonk]

heard the phrase "use AI to cure cancer!" a lot at NeurIPS this year and it bothered me, so I wrote about it: https://t.co/5UbfE1yru4

[Alexander Honkala @xhonk]

@KumarAGarg scRNA/ATACseq longitudinal post-injury (burn, bone break, heart attack, stroke, surgery) salutogenesis time series in peripheral blood

[epithelial mechanics fan club @EpiMechFC]

Hi, I’m David Brückner @d_brueckner. I’ll take you through how cells in a tissue can use information distributed by biochemical gradients to make decisions, and how we can measure such positional information.

https://t.co/UfK2r9EGRE

[Alexander Honkala @xhonk]

inb4 phase mediated stress granule memory tracking via time recording exosomes for Schekman’s 2nd Nobel https://t.co/mxRBkl4xmt

[Alexander Honkala @xhonk]

this is why I really want a home mass spec appliance: ppl deserve to be able to get good data about chemical composition and exposures in products & built environments *that does not depend* on the largesse of mfgrs in order to make informed choices about their exposures

[Sam D'Amico @sdamico]

There’s an emerging cross-partisan consensus on individually contentious topics — that we need to re-evaluate the advances brought by post-WW2 materials and chemical engineering now that we have a much better understanding of human biology and environmental processes.

[Alexander Honkala @xhonk]

this is awesome new work, immediately made me think of plasticity as topology a la Chaffer & Krishnaswamy: https://t.co/hpCoEBV2hw how is AP-1 pushing would-be forgetters back down the hill to form more stable treatment memories?

[Jessi Li @jess_ljx]

Excited to share our new
@biorxivpreprint in which we demonstrate the formation and maintenance of cellular memories in melanoma during acquisition of therapy resistance - dependent on the transcription factor AP-1 https://t.co/YBa6Gtbq5i (1/9)

[Alexander Honkala @xhonk]

+ Specific projects only feasible with exabyte-scale computing resources for data integration, modeling, and/or AI/ML development

[Alexander Honkala @xhonk]

+ Economic estimates of lost productivity from multi-party environmental review of new projects in energy, transportation, and/or housing
+ Prediction & justification of co-developments needed to achieve >50% ORR in adoptive T-cell immunotherapy for solid cancers

[Alexander Honkala @xhonk]

+ High-priority bioanalytes for improving dynamic variation resolution (e.g., diurnal fluctuations in prolactin)
+ Sector-specific integration maps for high-impact use of AI/ML tools even at 5% hallucination rates

[Alexander Honkala @xhonk]

Looking for author applicants in:
+ Viable cell and gene therapy business models for rare conditions and personalized medicine
+ Dispositive evidentiary standards for superconducting material testing

[Alexander Honkala @xhonk]

Today we launched a new Request for Content for articles covering technology development roadmaps, gap analyses, & missing dataset justifications: https://t.co/MddfSYwZrD We're trying out paying authors to write great content instead of making them pay us just to publish! #DeSci

[Alexander Honkala @xhonk]

anyone seen a good ref for the technical approaches being explored for overcoming the GvHD issues of allogeneic cell therapies, ideally w a breakdown of what's happened clinically so far?

[Alexander Honkala @xhonk]

@dr_alphalyrae I'm testing out doing it in public on @ResearchHub