Donald Xhuti

PhD candidate | Healthy aging, exercise, mitochondria

[Henning Langer @HenningLanger]

Very cool study, providing some of the strongest evidence to date for a potential benefit of the ketogenic diet compared to more carbohydrate-rich diets: https://t.co/dvbBMdVgDW

Not for weight loss, where calorie-count still seems key, but for fatty liver and glucose control.

[Donald Xhuti @xhutid]

@HaoYin20 A baseline of 850m on the 6MWT makes no sense, unless you start speed walking or jogging. In that case jogging for 6 minutes isn’t much of a test in healthy middle aged adults. The blood data is interesting though

[owl @owl_posting]

insane title

[Donald Xhuti @xhutid]

@HaoYin20 @cryptobeast 🫣🫣🫣

[Donald Xhuti @xhutid]

@PatrickStoa @Brady_H @doctorinigo Yes I noticed this too. Top and bottom graphs are good but those same values are inverted in the middle graphs

[Madam Mitochondria @Madam_Mito]

Modulating IL-11-dependent matrix stiffness to delay ovarian aging | Nature Aging https://t.co/Q5rLDJGG1w

[Exosome RNA @ExosomeRNA]

Exosomes are emerging as promising tools for regenerative medicine. A world-first burn treatment using extracellular vesicles helped a patient avoid facial skin grafts, highlighting their potential to promote healing and tissue... @hamhealth @McMasterU https://t.co/zLB7NM5XY4

[Donald Xhuti @xhutid]

@ethanjweiss And hes been the best player in the world since he was 21. I think its the GH injections he got as a kid

[Eric Topol @EricTopol]

A single 25 mg dose of psilocybin leads to brain structural changes that were seen at 1 month. From a cross-over study of 28 healthy volunteers, no prior psychedelic, who also were also assessed after 1 mg. Behavioral results in Figure
https://t.co/R0FKpitoMA

[Donald Xhuti @xhutid]

@HaoYin20 @mcollado_CIMUS So its EVs that drive paracrine senescence and not the SASP :o

This paper is cool

[Donald Xhuti @xhutid]

@Brady_H He almost had it

[Mike Lustgarten, PhD @mike_lustgarten]

Hopefully blood testing companies can measure GDF15 sooner than later...

A deep-learning based biomarker of systemic cellular senescence burden to predict mortality and health outcomes https://t.co/lqM7w3aPfJ

[DM1Research @DM1research]

Watershed moment: for first time results of clinical trial testing drug safety and efficacy in myotonic dystrophy T1 patients published in the New England Journal of Medicine.

[NEJM @NEJM]

Laura P.W. Ranum, PhD, describes the scientific foundations of a clinical trial of an antibody–oligonucleotide conjugate to treat persons with myotonic dystrophy type 1.

Read the editorial “A Trial of an Antibody–Oligonucleotide Conjugate,” from @UFMedicine, @UFMBI, @FixelInstitute, and @UFGenetics: https://t.co/eirDUYZZzJ

[Donald Xhuti @xhutid]

@Brady_H https://t.co/tiJJHHkokA

[Michael Mindrum, MD @MichaelMindrum]

My goodness.

[Matthew S. Alexander @Matt_Muscle_Guy]

New @PNASNews paper: Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging. https://t.co/HnFHHsHyeo

[Donald Xhuti @xhutid]

https://t.co/mhDKimT33b

Cool win for rapa!!!

“Short-term rapamycin treatment allows patients who fail repeated in vitro fertilization cycles with embryo developmental arrest to achieve high-quality blastocysts that yield successful pregnancy and live birth”

[Human Molecular Genetics @hmg_journal]

Combination treatment with antioxidants and creatine alleviates common and variant-specific mitochondrial impairments in Leber’s hereditary optic neuropathy patient-derived fibroblasts
https://t.co/g0O0mT7Jev

[Eric Topol @EricTopol]

Exercising fathers, enhanced endurance and metabolic heath in offspring, through sperm microRNAs (as demonstrated in mice)
https://t.co/Pak45uoWI4