100xyanni

RUO

[100xyanni @yannislongevity]

@doctormorphh doing both can be good as well too!
especially if goal is inflammatory and oxidative stress reduction

[Mgoes (bio/acc 🤖💉) @m_goes_distance]

Vanity drugs make more money than AI.

Billionaire investor @C_Angermayer explains why peptides, GLP-1s, psychedelics, longevity & performance enhancement are exploding.

And why optimizing the human body and mind will become the next trillion-dollar industry.

0:00 - Human Enhancement Is Here
06:38 - Trans vs Looksmaxxing
11:12 - Enhanced Games
22:32 - Next Red Bull
25:48 - Going Too Far
32:18 - Psychedelics Unlock
37:49 - Universal Happiness
43:30 - MDMA x Marriage
46:27 - 12 vs 2h Trips
54:18 - Trump, Ibogaine, Addiction
1:00:22 - Sex, Pleasure, Female Orgasm
1:10:04 - Vanity Drugs & Future

[Puma @pumamethod]

ejaculation triggers the same neurochemical cascade as a heroin hit. dopamine floods the nucleus accumbens, peaks for a few seconds, and then crashes below baseline. your brain then releases prolactin to suppress dopamine further. this is pharmacologically identical to the comedown after an opiate high

this isn't metaphor. this is fMRI data. brain imaging studies show that the neural activation pattern during orgasm and during heroin injection overlap almost completely. same regions. same neurotransmitters. same crash

the difference is that heroin is illegal and ejaculation is encouraged

- dopamine spikes to roughly 200% of baseline during ejaculation then crashes below baseline within minutes. the "post-nut clarity" is actually dopamine depletion creating a temporary window of non-desire
- prolactin floods the brain immediately after and stays elevated for up to 2 weeks. during this entire period motivation, drive, and ambition are chemically suppressed
- repeated ejaculation on consecutive days compounds the prolactin load. men who release daily are operating in a state of chronic prolactin elevation that suppresses their dopamine system permanently
- the brain adapts to frequent ejaculation by downregulating dopamine receptors. this is tolerance. the exact same mechanism as drug tolerance. you need more stimulation to feel the same reward
- this is why porn escalation happens. the receptors are burned. vanilla content stops producing enough dopamine. the brain demands novelty. this is textbook addiction neuroscience applied to sexuality
- withdrawal symptoms from stopping (flatline, irritability, insomnia, depression) mirror withdrawal from every other dopamine-depleting behavior because the mechanism is identical

you are running the same neurochemical cycle as an addict and the medical establishment won't call it that because there's no pharmaceutical solution to sell you for it

[NootBro @nootropicguy]

DSIP is the most underrated peptide for addiction recovery

- 97% success in opioid withdrawal
- 87% success in alcohol withdrawal
- Minimal tolerance/side effects

Similar results in 2 other small open-label human trials

Nobody is talking about this yet

[100xyanni @yannislongevity]

@aestheticprimal interesting
what about serotonin and the serotonin depression model
neuro plasticity??

[_aestheticprimal_ @aestheticprimal]

Subjective increases in IQ felt on certain nootropics

(from 2017 survey done on r/Nootropics including 380 participants)

[BasedBiohacker @BasedBiohacker]

how it feels being the only person in your friend group who’s on health twitter

[100xyanni @yannislongevity]

Semax mogs at night
Why?
Slow wave sleep is when we humans release the highest amount endogenously of BDNF
Timing either semax or adamax around your sleep window, could potentiate the BDNF secretion to another level through TRk-b receptor modulation. No studies on this, just thinking in simple terms, same thought process behind insulin, used whenever you are the most receptive to it.

[100xyanni @yannislongevity]

https://t.co/43cMCAPTpV
shop now

[100xyanni @yannislongevity]

@ScottMcG15 @babahoshii lmao wrong😭
correlation ≠ causation
understandable pov tho but really not what it is

[100xyanni @yannislongevity]

@BasedBiohacker 😭😭😭 on my soul.

[BasedBiohacker @BasedBiohacker]

how ”natural” mfs must feel grinding on nothing but pure delusion when we have phenylpiracetam, pinealon, bromantane, modafinil, selank, amantadine, and 9-Me-BC readily available at our fingertips thanks to this wonderful invention called the ”internet”:

[100xyanni @yannislongevity]

Tesa is genuinely so inefficient
FDA approval is for HIV associated lipodystrophy a specific disease population. that’s why the data is strong. It doesn’t translate to superiority for general GH optimization. Ipamorelin hits the same axis, produces a cleaner GH pulse with no cortisol or prolactin elevation, and costs 95% less.
the tier list is ranking regulatory approval not clinical effectiveness. those are very different things, and to be fair Ipamorelin also sucks when compared to the og, GROWTH Hormone.

[100xyanni @yannislongevity]

People focus almost entirely on dopamine when it comes to stimulant damage but the glutamate side is just as significant
there’s a transporter in the nucleus accumbens called the cystine-glutamate exchanger.

It’s job is to maintain glutamate balance in the synapse. chronic stimulant use impairs this transporter. when it stops working properly glutamate accumulates and the NMDA receptors that respond to it start to desensitize.

This is a big part of why people feel flat and foggy even on their days off. i noticed this myself the off days weren’t actually recovery days. something else was going on underneath the dopamine picture.

NAC restores exchanger function. Agmantine works on the NMDA receptor side directly. both cheap, both well researched, neither gets talked about in the context of stimulant use.

[100xyanni @yannislongevity]

Most people assume their adderall stopped working because of tolerance
and they’re not entirely wrong but they’re missing what’s actually happening.
this isn’t the same tolerance you build to caffeine or anything else. your brain is physically reducing the number of dopamine receptors it expresses at the gene level. it’s an adaptive response to being overstimulated for too long.
i run stimulants. i understand why people just cycle off and hope it resets. it helps somewhat but it doesn’t fix the core problem. the receptors that were downregulated don’t just come back because you took two weeks off.
you have to actively address the synthesis side. bromantane upregulates the enzymes your brain uses to produce dopamine in the first place. 9-MBC promotes the regeneration of the dopaminergic neurons themselves. that’s a fundamentally different intervention than just giving your receptors a rest.

[100xyanni @yannislongevity]

@OrientalBlau this is heaven

[Michael Morelli @morellifit]

Many people assume Cialis (tadalafil) is only for one specific purpose, getting hard.

It is actually a highly effective tool for overall blood flow, cardiovascular health and potentially hair health.

Tadalafil, explained: (1/16)

[100xyanni @yannislongevity]

@morellifit same mechanism driving your vascular dilation is also increasing your neuro plasticity and there’s also emerging data on cerebral blood flow improvement via the nitric oxide potentiation in your cerebral vasculature which simply means more oxygen & nutrient delivery to the brain

[100xyanni @yannislongevity]

@morellifit Great post man, genuinely. And the thing is there’s more. The cognitive effects, we know it crosses the blood brain barrier, PDE5 inhibition in CNS tissue drives CGMP accumulation, which intern activates PKG, which then phosphorylates CREB, and up regulates BDNF expression.

[BasedBiohacker @BasedBiohacker]

"YOU THINK YOU ARE BETTER THAN ME DON'T YOU!?!??"

yes bruv in every measurable metric i am better than you