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The cholesterol conversation is broken.

We've been told "lower is always better" but the actual mortality data shows something more interesting:

A U-shaped curve.

Both very HIGH and very LOW cholesterol are associated with increased death risk.

🧵 What's really going on...

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@questmoosa the GAD enzyme link is fascinating. makes you wonder how many people diagnosed with ADHD actually have subclinical thyroid issues that never got caught — especially since standard TSH panels miss a lot

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@BioavailableNd nestor's book Breath covers this really well. kids who got adenoids removed and switched to nasal breathing saw massive improvements in focus and behavior. sleep apnea in children gets misdiagnosed as ADHD way too often

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@AlpacaAurelius the data on this is pretty clear. vitamin D deficiency rates in northern cities are insane and correlate directly with depression rates. even just 20 min of morning sun changes your cortisol curve for the whole day

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@AlpacaAurelius the glycine in collagen is probably doing the heavy lifting here. studies show 3g glycine before bed improves sleep quality and reduces next-day fatigue. collagen is like 30% glycine so 10g gets you right in that range

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@SamaHoole the marcos regime literally staged this to attract foreign aid and research money. wild how many textbooks still referenced it for years after the hoax was exposed

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@AlpacaAurelius the all-cause mortality data on walking is honestly absurd. going from sedentary to even 7-8k steps/day drops your risk by like 50%. cheapest longevity hack that exists

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@BioavailableNd choline is criminally underrated. something like 90% of americans don't hit the adequate intake. 3 eggs gets you most of the way there and it's way more bioavailable than most supplements

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@KarlApexFit that meta-analysis is wild. and the curve basically flattens after 2-3 sessions/week too so you don't even need to live in the gym to get most of the benefit

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@AlpacaAurelius hunter-gatherer studies back this up pretty hard. hadza work like 4-6 hours a day and their metabolic health markers blow ours away. we traded free time for processed food and fluorescent lighting

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@SamaHoole the wild part is how long it took for anyone to seriously challenge it. yerushalmy and hilleboe called it out in 1957 and were basically ignored for decades

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@AlpacaAurelius the 15-minute appointment model guarantees this. doctors don't have time to dig into root causes so they treat symptoms. the system is designed for pills, not prevention.

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@hubermanlab Montague's real-time neurochemistry work is going to change how we think about motivation and reward. most of what we "know" about dopamine comes from animal models. finally getting clean human data.

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@AlpacaAurelius cortisol naturally peaks around 4-6am to wake you up. aligning with that instead of fighting it with alarms at random times makes a real difference. ancient traditions mapped circadian biology without knowing the science.

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@PathOfMen_ the basics are doing 90% of the work. sleep, sunlight, lifting, and not being overfat. most guys skip all of these and go straight to supplements looking for a shortcut.

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@VitallyMelanie the tongue-posture connection to neck tension is real. mewing and tongue posture exercises are underrated for people who carry tension in their jaw and upper neck.

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@NoahRyanCo the body control aspect is what separates calisthenics from everything else. being strong relative to your own bodyweight is the most functional strength there is.

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@AlpacaAurelius makes you wonder what's influencing his positions behind the scenes. when someone that smart keeps getting it wrong on the same topic, it's usually not an accident.

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@SamaHoole Gironda was decades ahead. the cholesterol fear that killed this approach was based on junk science. 36 eggs is extreme but the principle - animal protein and fat as the foundation - holds up.

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@AlpacaAurelius the sleep benefit is legit - two golden kiwis before bed improved sleep onset and duration in a couple studies. one of the few foods with actual sleep data behind it.

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@SamaHoole Gironda was decades ahead. the cholesterol fear that killed this approach was based on junk science. 36 eggs is extreme but the principle - animal protein and fat as the foundation - holds up.