Yu Zhao

Postdoctoral Research Fellow, Bioinformatics, Systems Immunology @BrighamWomens @broadinstitute

[Yu Zhao @yu48693]

@social_visualiz #wordcloud @mercola

[Dylan Kotliar @DKotliar]

Paper from me @michecurtis @soumya_boston and co out now in @naturemethods! We now call the tool starCAT instead of *CAT but the strategy is the same: Build a catalog of ~50 interpretable T cell gene expression programs + use them to interpret new data https://t.co/qCJFcGg88B

[Yu Zhao @yu48693]

Our latest work on T cell annotation pipeline TCAT is now online! Feel free to try out and discuss. Happy to be involved. https://t.co/G7BdHTu82P

[Soumya Raychaudhuri সৌম্য রায়চৌধুরী @soumya_boston]

So excited to share our latest with Betty Diamond and many colleagues from the AMP RA/SLE consortium, @NIH_NIAMS , and @NIAIDNews ! A large-scale blood and tissue atlas of Lupus Nephritis! https://t.co/c1SAlMnRcu

[Nariaki ASADA,M.D.,Ph.D. @nariaki_asada]

Thrilled to announce the publication of our latest manuscript on CD4 Trm cells in Nature Immunology! @NatImmunol

A huge thank you to our amazing team and collaborators for their incredible work!

https://t.co/Xm0ceymQnl

[Saori Sakaue @saorisakaue]

📣Excited to share my last postdoc paper with
@soumya_boston on eQTL mechanisms depending on where the RNA is in the cell! @BrighamResearch @broadinstitute
TL;DR:Early RNA eQTL variants in the nucleus and late RNA eQTL variants in the cytosol have distinct molecular mechanism🧵👇

[Yakir Reshef @YakirReshef]

Excited to tell you about VIMA (Variational Inference-based Microniche Analysis), our deep learning + stats hybrid for case-control analysis of multi-sample spatial molecular datasets. 🧵👇https://t.co/uEGIbNsNCZ. @soumya_boston , @broadinstitute , @BrighamResearch

[Zepeng (Phoenix) Mu @ZepengMu]

Excited to share the final chapter my PhD research on @medrxivpreprint! eQTLs only explain 30% of GWAS loci and 11% of trait heritability. Here we investigate if epigenetic QTL can provide new insights at the remaining GWAS loci. https://t.co/vzkyjbTdkC

[Jan Broder Engler @JanBroderEngler]

Tidyplots makes it easy to generate publication-ready plots for scientific papers 🚀

https://t.co/j0S95nhvJa

[Soumya Raychaudhuri সৌম্য রায়চৌধুরী @soumya_boston]

Hi friends! Genotype-Neighborhood Associations (GeNA) by @LaurieRumker et al is now published! @broadinstitute @BrighamResearch https://t.co/sxXJsqRkhK

[Yu Zhao @yu48693]

Happy to be involved in this study. https://t.co/Faqi2mFn8v @krebs_lab @stefan_bonn

[Yu Zhao @yu48693]

@_yji_ Congrats Yuge for this nice work

[Yu Zhao @yu48693]

@YoshiTomofuji Congrats!

[CKLab @krebs_lab]

Science Immunology has just published our pooled in vivo CRISPR-screen (iCROP-seq). In this study we also address T cell plasticity in the kidney of ANCA-GN patients. Thanks to everybody involved in this study!
https://t.co/ae71AvI59v

[Yu Zhao @yu48693]

@krebs_lab Congrats to the fantastic work

https://t.co/13U9C9eOg5

[Nature Reviews Genetics @NatureRevGenet]

SCENT defines non-coding disease mechanisms using single-cell multi-omics https://t.co/ipdfRSFt4g #ToolsoftheTrade by @saorisakaue @harvardmed @broadinstitute #NRGToT

[Soumya Raychaudhuri সৌম্য রায়চৌধুরী @soumya_boston]

AMP-RA study defining chromatin states in inflammatory #RheumatoidArthritis tissue is out! We argue: single cells can be grouped into chromatin classes, encompassing multiple transcriptional cells states. @NIH_NIAMS @broadinstitute @BrighamResearch
https://t.co/huAyX4FGyG

[Elizabeth Dorans @elizabethdorans]

Excited to share our preprint proposing pgBoost, an eQTL-informed gradient boosting model that integrates scores from single-cell enhancer-gene linking methods and genomic distance to predict regulatory SNP-gene links (a key step in interpreting GWAS discoveries)!🧬

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[Yu Zhao @yu48693]

@ZhenweiZhang3 @Nature Congrats!

[Dylan Kotliar @DKotliar]

@michecurtis and I are thrilled to share our preprint "Reproducible single cell annotation of programs underlying T-cell subsets, activation states, and functions" from the @soumya_boston lab @BrighamResearch and @broadinstitute!

https://t.co/OexYxSnc3D

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