Zexiang Chen

Postdoc @DJSiegwart, Siegwart Lab, UT Southwestern Medical Center;
PhD @jwattsgroup& @ESontheimerLab, UMass Chan Medical School

[GDEatUTSW @GDE_UTSW]

Our lab member Yufen @YufenXiao gave a fantastic talk on her recent publication: "High-density brush-shaped polymer lipids reduce anti-PEG antibody binding for repeated mRNA therapeutic delivery." at the #CRS2025!
Congrats! 🎉 #mRNA #LNP

[GDEatUTSW @GDE_UTSW]

🚨 Exciting news! Dan is giving a talk on the development of selective organ targeting (SORT) lipid nanoparticles (LNPs) for genome correction of disease-causing mutations. @DJSiegwart @CRSScience
#CRS2025 #Nanomedicine #LNP #GenomeEditing

[GDEatUTSW @GDE_UTSW]

Big congratulations to Yehui Sun, a PhD candidate in Siegwart Lab, for receiving the 2025 Ida M. Green Award! Your dedication, leadership, and excellence truly inspire us all!

[RNA Therapeutics Institute @RTI_UMassChan]

Daniel J. Siegwart on Development of selective organ targeting (SORT) lipid nanoparticles (LNPs) for genome correction of disease causing mutations #RNATx2025

[Daniel Siegwart @DJSiegwart]

It was an honor to be inducted into the National Academy of Inventors (NAI) ⁦⁦@AcadofInventors⁩ tonight!

[GDEatUTSW @GDE_UTSW]

Our lab’s latest publication in @NatureBiotech led by Minjeong Kim and @DJSiegwart. Read the full story here: https://t.co/TuTFyc383l

[UTSW Science @UTSWScience]

Science at #UTSW goes deep – down to the nucleic level. Research led by @DJSiegwart has unlocked synthetic lipid nanoparticles as delivery vehicles for genetic medicines. Explore more in the latest edition of #DiscoveryAtUTSW. https://t.co/ANCIQt64cK

[UT Southwestern Biomedical Engineering @utswbme]

Throwing it back today to celebrate @YehuiSun, @GDEatUTSW Graduate Student Researcher, for earning a scholarship award to attend @KeystoneSymp's Precision Genome Engineering meeting in March. Yehui gave a talk on the lab's most recent publication in Science.
#ThrowbackThursday

[Young Scientist Committee YSC-CRS @CRS_YSC]

@C_Martins__ and @juan_avetrece just wrapped up a fantastic interview with @DJSiegwart for the upcoming @CRS_YSC & @DDTReMedia joint series. Insightful, inspiring — and just the beginning. Stay tuned for what’s coming!
#NewBeginnings #YoungScientists @CRSScience

[GDEatUTSW @GDE_UTSW]

Excited to share our new paper in @NatureMaterials 🔔 led by @YufenXiao @DJSiegwart Read the full story here: https://t.co/5FQjpfR3IF

[RNA Therapeutics Institute @RTI_UMassChan]

RTI’s Jon Watts @jwattsgroup sharing some exciting work on a new ASO platform enabling delivery to lung against an asthma target at the @UMassChan BRIDGE Fund Innovation Showcase this morning!

[Sophia Shi @sophmshi]

Excited to share our new study in @Nature! We uncover how the vascular glycocalyx—a carbohydrate-rich coating on blood vessels—plays a crucial role in brain health and aging. A @wysscoray & @CarolynBertozzi labs collaboration. 🍭🧠 #glycotime (1/12)
https://t.co/To4Oz0MN0G

[nature @Nature]

The first schizophrenia medication in decades with a new mechanism of action won US regulatory approval

https://t.co/p1bh4JH6gl

[nature @Nature]

There must be something about the human brain that’s different from the brains of other animals — something that enables humans to plan, imagine the future, solve puzzles, tell jokes and do the many other things that together make our species unique
https://t.co/hmQYkWGVFc

[Karolinska Institutet @karolinskainst]

Researchers have developed a method that enables three-dimensional RNA analysis at cellular resolution in intact mouse brains. The new method can transform our understanding of brain function. Research by @peruhlen, @kanashigeaki, et al. Published in @ScienceMagazine.

[Ugur Uslu @UgiUslu]

Published today @NatureBiotech: @CarlHJune and I reveal how CAR T cells are finally tackling solid tumors!
@PennPPA @PennMDForum

https://t.co/wJkfMfVxgC

[GDEatUTSW @GDE_UTSW]

Excited to be in Boston for the @mrnaconference ! Tomorrow, Dan @DJSiegwart and alum @LianXizhen will present our works on in vivo lung stem cell correction in mice, as well as bone marrow-homing LNPs for gene editing in hematopoietic stem cells. Looking forward to sharing! 🧬

[Science News @SciencNews]

The immune response

[Patrick Hsu @pdhsu]

🧵In new work, we report a systematic engineering roadmap to optimize large serine recombinases (LSRs) for direct, site-specific insertion into the human genome 🧬. We achieved over 50% insertion efficiency and 97% genome-wide specificity, a 10X improvement over our previous work

[Ildar Gainetdinov @IGainetdinov]

Excited to share our unexpected finding: piRNA pathway designed to protect the genome from invading nucleic acids created a population of selfish small RNAs that have perpetuated themselves for the past hundred million years of mammalian evolution. https://t.co/9Nm1iLfBug