Swick

[Moosa @questmoosa]

Few people know this

Vitamin E was initially discovered in 1938 as a “fertility factor”.

vitamin E is an antioxidant, it lowers oxidative stress (caused by free radicals) and therefore impacts hormones (T3 and T4) levels positively, by protecting them.

studies have also shown it to prevent and lessen the effect of lipid peroxidation of PUFA, and therefore protect the body from the oxidative damage that would otherwise ensue

powerful stuff (great for looksmaxxing too)

[Dalton (Analyze & Optimize) @Outdoctrination]

Saffron restores motivation + spark for life in clinical trial.

Anhedonia is that feeling of meh. I don't care. Whatever.

Yet adding on 30 mg of saffron reduced anhedonia substantially over antidepressants alone.

This coincides with increases in dopamine neurotransmission and BDNF signaling.

[Dalton (Analyze & Optimize) @Outdoctrination]

Vitamin C can powerfully reduce fatigue, even improving energy levels within hours in studies.

This first study looked at people exhausted from work, and initiated 6 grams of vitamin C daily, for 2 weeks, as therapy.

They also measured other biomarkers to see if vitamin C improved anything else.

The results were amazing.

Vitamin C had a potent anti-fatigue effect.

They used two different measures of subjective fatigue, improving by >30% in one and ~15% in the other.

Meanwhile, related biomarkers improved across the board:

➞ HbA1c (insulin sensitivity)
➞ Cortisol (often high in people with chronic fatigue)
➞ Liver enzymes (ALT, AST, r-GTP, measures of liver damage)
➞ CRP (inflammation, known player in fatigue)

Another study in 2012 showed even more striking benefits.

They used a single 10g IV dose of vitamin C, again in office workers who were just exhausted from work.

They measured how fatigue varied shortly after.

Literally within hours, people on the vitamin C had notable reductions in fatigue.

People on placebo noticed nothing.

This effect persisted til the next day - their energy level remained higher.

One more study here from 2022, this time in healthy young adults.

They were more focused on mental fatigue here and measured their performance in response to a multitude of cognitive assessments.

People taking 500 mg 2x a day of vitamin C showed:

➥ Less fatigue
➥ Improved attention
➥ Better "absorption" (memory of study content)

in comparison to placebo.
People taking the vitamin C showed better reaction times on a cognitive assessment.

So vitamin C's anti-fatigue properties showed both objective and subjective improvements.

Vitamin C is actually concentrated in the brain, more so than almost any other tissue.

There, it has a number of different roles, especially as it pertains to fatigue.

1. Antioxidant / anti-inflammatory roles - vitamin C helps recycle vitamin E and acts as an independent free radical scavenger. These properties mean it reduces damage to neurons and microglial activation, two key drivers behind fatigue.

2. Neuromodulation - vitamin C plays a quasi neurotransmitter role, mainly by upregulating the glutamate transporter, which lowers synaptic glutamate levels. This means reduced excitotoxicity in the brain, less mitochondrial overload and thus better mental performance.

3. Vitamin C also is a required cofactor in both the synthesis of norepinephrine, a critical neurotransmitter for wakefulness, and it is needed for the synthesis of dopamine.

4. Blood flow - one key factor in fatigue is reduced blood flow to the brain. Vitamin C is known to have protective effects for the vascular system, sparing nitric oxide content and preserving the collagen of the vessels, meaning better blood flow to the brain.

[Nicolas Hulscher, MPH @NicHulscher]

BREAKING: ADVANCED ALZHEIMER’S PATIENT REGAINED SPEECH, MEMORY, AND BLADDER CONTROL AFTER SINGLE PSILOCYBIN DOSE

An 80-year-old woman with advanced Alzheimer’s — who had barely spoken for YEARS — experienced RAPID and SUSTAINED improvement after taking 5g of psilocybin mushrooms.

During the acute phase, she entered a prolonged deep sleep-like state with profuse sweating.

~19 hours later, she spontaneously started talking again for HOURS — sharing detailed autobiographical memories she hadn’t expressed in years.

Over the following days, her family reported improved memory, walking, emotional connection, speech, and regained bladder control.

After 1 month, bladder control REMAINED RESTORED, and she was still functionally improved compared with baseline.

While this is just one published case report, the implications are enormous given that there are currently NO approved medications known to produce effects like this in advanced Alzheimer’s.

These findings urgently need replication. For millions watching a parent or loved one disappear to Alzheimer’s, even the possibility of restoring lost function warrants serious scientific investigation.

[Declaration of Memes @LibertyCappy]

Just another day in the matrix

😏

[Dr. Eric Berg DC @dr_ericberg]

Want to hear something wild? There's a specific microbe called Lactobacillus reuteri that's missing in 95-96% of the population, and its absence could be linked to a host of modern health issues.

This microbe, when restored, has been shown in studies to increase oxytocin, the "love hormone," which can improve social behavior and even impact physical attributes like skin thickness and muscle mass.

The original discoverer found this microbe everywhere in the 1960s, even in breast milk, but over time, it's virtually disappeared from the human microbiome, likely due to antibiotics and modern living. It makes you wonder how much of our current health crises, from gut issues to social isolation, could be tied to losing these fundamental microbes.

It's truly astounding how replacing something our bodies were meant to have can have such widespread beneficial effects, from better sleep to improved body composition and even potentially reversing chronic conditions.

Dr. Eric Berg, DC, not MD; information only

[Bailey Klemmensen @iiKlemm]

Competitive gamers: In-game stress can nuke your reads.

This study found 2g L-Tyrosine improved decision-making RT in high-demand tasks without hurting accuracy.

Dopamine depletes under pressure → tyrosine keeps the tank full.

Try this → 2g L-Tyrosine, 75 min before queue.

[FoundMyFitness Clips @fmfclips]

If you’re planning to conceive, fertility prep should start long before the pregnancy test

Ideally, the groundwork starts months to a year out:

• Exercise consistently
• Prioritize whole foods
• Lose excess body fat if needed
• Stop alcohol ideally 4–6 months before trying to conceive
• Cut down or eliminate caffeine when actively trying to conceive
• Cover foundational nutrients like fish oil, magnesium, and a multivitamin
• Minimize plastic exposure (reverse osmosis water filter, no plastic bottles, no hot food in plastic, and avoid receipts)

Women should add a prenatal with methylfolate well before conception

Men should prioritize sperm mitochondrial health with nutrients like zinc, vitamin C, and ubiquinol

The goal is to improve the metabolic, micronutrient, and epigenetic environment both parents bring into conception

[Carnivore Aurelius ©🥩 ☀️🦙 @AlpacaAurelius]

amongst all compounds studied, glycine is one of the only ones that extends lifespan over 20% across many species.

glycine boosts lifespan up to 30% in mice, rats, worms & flies.

this is a huge reason why I take collagen every day.

[Ricardo De Spirito Balbuena. @elzorrotacneno]

Desparasitantes Naturales:

1. Semillas de Calabaza:
- Elimina: Lombrices y tenias.
- Método: Consumir 15-20 gramos de semillas crudas y sin sal diariamente durante una semana.

2. Ajo:
- Elimina: Lombrices intestinales y giardias.
- Método: Comer dos o tres dientes de ajo crudos diariamente, preferiblemente en ayunas.

3. Zumo de Zanahoria:
- Elimina: Ayuda a eliminar lombrices intestinales.
- Método: Consumir un vaso de zumo de zanahoria fresco cinco veces al día durante cinco días (método "5x5").

4. Semillas de Papaya:
- Elimina: Lombrices y giardias.
- Método: Comer una cucharada de semillas de papaya trituradas con miel por la mañana en ayunas durante una semana.

5. Aceite de Coco:
- Elimina: Lombrices intestinales y giardias.
- Método: Consumir una cucharada de aceite de coco virgen extra en ayunas diariamente durante una semana.

6. Jengibre:
- Elimina: Lombrices intestinales y giardias.
- Método: Consumir infusión de jengibre fresca o añadir jengibre rallado a las comidas diariamente.

7. Vinagre de Manzana:
- Elimina: Lombrices intestinales.
- Método: Beber una cucharada de vinagre de manzana diluida en un vaso de agua antes de las comidas durante una semana.

8. Orégano (Aceite de Orégano):
- Elimina: Giardias y amebas.
- Método: Consumir 2-3 gotas de aceite de orégano diluido en un vaso de agua, dos veces al día durante una semana.

9. Ajenjo:
- Elimina: Lombrices intestinales y tenias.
- Método: Consumir en forma de té o suplemento según indicaciones.

10. Nogal Negro:
- Elimina: Lombrices intestinales y tenias.
- Método: Consumir en forma de extracto o suplemento según indicaciones.

11. Clavos de Olor:
- Elimina: Lombrices, amebas y huevos de parásitos.
- Método: Consumir en forma de té (hervir 1 cucharadita de clavos en una taza de agua) o suplemento según indicaciones o una cucharadita triturada en ayunas en una taza de agua.
En luna llena los parásitos están más activos y migran hacia el intestino para reproducirse y poner sus huevos

12. Semillas de Chirimoya:
- Elimina: Lombrices y otros parásitos intestinales.
- Método: Triturar las semillas y consumir con agua o jugo durante una semana.

13. Semillas de Lino:
- Elimina: Lombrices intestinales.
- Método: Consumir 1-2 cucharadas de semillas de lino molidas al día, mezcladas con agua o yogurt.

14. Semillas de Sésamo:
- Elimina: Lombrices y tenias.
- Método: Consumir 1-2 cucharadas de semillas crudas, molidas o enteras, diariamente.

15. Semillas de Chía:
- Elimina: Lombrices intestinales.
- Método: Consumir 1-2 cucharadas de semillas remojadas en agua, batidos o alimentos diariamente.

[Lorwen Harris Nagle, PhD @LORWEN108]

A Stanford neuroscientist warns high cortisol wrecks memory, enlarges your fear center, and make your brain feel broken.

If I wanted to fix it naturally, I'd do these 8 things every day:

1. Walk barefoot on grass for 5–7 minutes.

[Anish Moonka @anishmoonka]

Scientists shut off the dopamine in some rats and they stopped eating. Food everywhere. They starved in a full cage, not because they hated it. Put sugar on their tongue and they licked their lips. They still liked it. They just lost the drive to go get it.

This is one of the strangest things we know about the brain, and it traces back to a researcher named Kent Berridge at the University of Michigan. Your head runs two different systems. One is wanting, the push that gets you off the couch and moving. The other is liking, the good feeling once you are in it. Dopamine runs the wanting. The enjoyment runs on separate wiring. So you can be sure you will love something and still feel almost no pull to start it.

That is the man in the cartoon, swinging at rock with diamonds all around him. He could see the good stuff. He just could not make himself dig toward it.

Once you see why, the usual story about procrastination stops making sense. We say lazy, or bad with time. Mostly, it is neither. Two psychologists, Fuschia Sirois and Tim Pychyl, argued back in 2013 that it runs on emotion. A task makes you feel something you would rather not feel, even just the small dread of starting, and putting it off makes that feeling vanish on the spot. So you scroll, or you suddenly need to clean the kitchen. Dodging the task is a quick hit of relief, and your brain grabs it. The bill goes straight to future-you, who is left holding the guilt and the deadline.

You can even see it on a brain scan. In 2018, a team in Germany scanned 264 people and matched the scans against how much each person put things off. The big procrastinators had a larger amygdala, the little alarm bell deep in the brain that flags anything risky. They also had a weaker link to the part meant to quiet that alarm and get you moving, a region called the dorsal anterior cingulate cortex. Loud alarm, weak off-switch.

And if this is you, you have plenty of company. A big 2007 review found that 80 to 95 percent of college students procrastinate, that roughly one in five adults does it long-term, and that more than 95 percent of them wish they could quit. Students alone burn about a third of their day on it.

The fix falls out of that same split. If wanting and liking are two different systems, then waiting to "feel like it" is waiting for a bus that may never come. The main treatment for the severe version, called behavioral activation, flips the order. You start first, as small as you can stand, before any motivation shows up. The wanting tends to arrive a few minutes after you begin. The diamonds were there the whole time. You just have to swing the pick before you feel ready.

[maya @ArsAlendi]

Foods that could bind up microplastics:

- okra, molokhiyya, yamaimo/mountain yam, nopal/prickly pear, malabar spinach, and similar mucilaginous foods
- kimchi, sauerkraut, and other lacto-fermented foods
- pectins such as citrus or apple pectin (also found in jams, stewed fruits and applesauce)
- flax, chia, and psyllium

[Dalton (Analyze & Optimize) @Outdoctrination]

Biotin megadosing nearly triples testosterone in animals.

Otherwise known as vitamin B7, biotin:

• Raises total testosterone, without changing LH
• Supports testicular steroid production

0.25 mg / kg body weight (human equivalent).

Biotin is 100% absorbed orally, no known toxicity.

[Dalton (Analyze & Optimize) @Outdoctrination]

Depression is inflammation in disguise.

Inflammatory markers are higher across the board, sometimes by 2-3X, in depressed people.

Anti-inflammatories:

• Aspirin
• Taurine
• Pregnenolone/progesterone
• Red light
• Glycine
etc

should be explored.

[daz @MetamateDaz]

You’re born onto a planet you never asked to exist on…

and society immediately hits you with: “Okay, now go earn the right to eat, sleep, rest, and have shelter.”

Like… zoom out for a second.

We’re floating on a rock in infinite space and we created a game where you have to spend most of your life working just to not starve or freeze to death.

The whole concept is actually insane when you think about it.

[Prof. Dr. Kaan Yılancıoğlu @drkaanyl]

Şu egzersiz lenfatik drenajı, tüm vücutta kan akımını arttıran, neredeyse tüm vücudu çalıştıran belki de dünyanın en iyi egzersizi ... 👇

[Muscle Forge @LearnLoopz]

Give your neck a break

[Hans Amato @HansAmato]

How to drop cortisol by 43% through food alone:

➮ Milk daily, dropped cortisol from 479 to 317 nmol/L in 2 weeks in my own labs

➮ White button mushrooms daily, lowers endotoxin, endotoxin is one of the biggest cortisol drivers most men never test for

➮ Activated charcoal away from food; binds LPS before it reaches the bloodstream and triggers the stress cascade

➮ Carbs with salt at every meal; low glycogen raises cortisol. This is why skipping breakfast makes anxiety worse

➮ Remove caffeine on an empty stomach; spikes cortisol before the day starts

➮ Fix transit time; slow transit = more fermentation = more endotoxin = more cortisol. The loop runs silently

➮ Fix the gut first; everything else is downstream

Most men are treating cortisol symptoms. The source is almost always the gut.

[Sergio Ferrero @calotonterias]

Añadir romero al freír reduce significativamente la oxidación de los aceites y puede disminuir hasta un 74% la formación de compuestos dañinos.