WideBack

CEO @HeraGamesStudio - Degen - AI - Game dev - DeFi - Neuroscience.

Onboarding the next billion of people through GameFi.

[Risk @RiskOnBase]

How to win as a player of @RiskOnBase ?

The most exciting on-chain Gaming experiment.

Will you let your country get overrun ?
To submit to the enemy ?

Wake up, and fight anon.

J-5.

🔔 If you're ready to be a Leader.

[WideBack @0xWideBack]

Without Fable life is bleak...

[WideBack @0xWideBack]

@argofowl 🫡

[Sardoche 🇫🇷 @Sardoche_Lol]

@JLMelenchon Seul moment où vous êtes pour la propriété privé c'est pour draguer les gamers finalement.

[WideBack @0xWideBack]

@VittoStack Even in EVM smart contract security audit, I was able to work with the new Fable…

The rerouting seems a bit overblowned

[WideBack @0xWideBack]

Limits are supposed to be higher, but I hit my 5hours limit multiple times a day now, when I barely used 60% of it in hardcore sessions with multiple agents before.

Burn through my 60% of my max plan in less than 24hours…

[ClaudeDevs @ClaudeDevs]

Claude Code weekly limits are increasing 50%, now through July 13.

Live now for all Pro, Max, Team, and seat-based Enterprise users.

[Nick Levine @status_effects]

The Economist: "Talkie, a model trained only on text from before 1931, thinks God is extremely important and is “very proud to be a citizen of Great Britain”. It is a bigger believer in law and order than any frontier model we tested."

[WideBack @0xWideBack]

Haven't slept since Fable came back - it's genuine magic, not open sourcing it might actually be a crime against humanity

[Bryan Johnson @bryan_johnson]

Bad news #1:

I have an autoimmune disease. My stomach is eating itself.

Bad news #2:

2–5% of people have this, too. Likely more, because it hides.

Good news:

I'm going to try and solve it. Will share all.

As a kid, I ate sugar cereal, drank sugary soda, and gobbled down fast food. I had a few healthy years in my early 20s but then became a young father of three and began building a business.

Juggling that stress and grind, I let my health slip and gained 40 lbs. Within a few years I’d fallen into a deep, chronic depression.

Somewhere in that timeline, my body began developing an autoimmune process affecting my thyroid and then my stomach lining.

It’s called Autoimmune Gastritis (AIG).

My hypothyroidism got diagnosed when I was 21 years old with a routine blood draw. That enabled me to begin proactive management, supplementing levothyroxine and Armour Thyroid. They are the hormones my body should be producing on its own but wasn’t.

By taking these pills daily, my body was able to operate as though my thyroid was functioning properly. What I didn’t know was that something else was going on inside my body: my stomach had begun attacking itself. But there was no routine test to find out and I didn’t have any symptoms.

I just discovered it in May. I'm unsure how long I've had it. AIG causes irreversible damage: nutritional deficiency, anemia, and over a long horizon, elevated cancer risk. When AIG is discovered today, standard medical care concedes defeat, stating that nothing can be done except managing the condition, no matter how awful or lethal the effects.

Looking back over the past few years, I can now see the early signals we were picking up in measurement but hadn’t connected the dots. For 11 years, I’ve had low ferritin, without anemia. We continually tried to raise my iron levels with food and supplementation but nothing would work.

We chased the obvious solutions first. A plant-based diet means all my iron is the hard-to-absorb, non-heme kind. Hard training, sauna, and hyperbaric oxygen all raise the body's demand for iron. But none of them explained the core failure: despite me taking iron orally, trialing every formulation, and using every timing trick, none of the iron would stick.

What I didn’t fully appreciate until recently is how many stones my previous providers had left unturned. The low ferritin kept getting explained away but not fixed.

I overhauled my medical team earlier this year. It was the rebuild to lay the groundwork for Immortals Care, our $1M a year protocol. With greater capacity, we revisited everything.

On the surface, my low ferritin was easy to dismiss by most standards of care. My hemoglobin and hematocrit were normal. Ferritin measures stored iron, while hemoglobin measures circulating iron, and because the body drains its reserves first to keep hemoglobin normal, you can be fully iron deficient with a perfectly normal hemoglobin and hematocrit.

This is why my low ferritin kept getting dismissed: the numbers that define anemia looked fine, so no one asked why my iron reserves wouldn't refill.

My team pressed on that question. They first turned to a colonoscopy. I was 48 years old and overdue. It was good health hygiene to have while also serving a specific purpose of searching for a hidden source of blood loss such as a polyp or even cancer in my bowels. Either one of those would be an explanation of why the iron kept disappearing.

At the same time, they began connecting the dots. Iron absorption depends on stomach acid, so one theory was that my stomach acid was disrupted. They also knew that thyroid and stomach autoimmunity often travel together, so often that the pairing has a name: thyrogastric syndrome.

Put against my 27+ year history of autoimmune thyroid disease, the pieces pointed to a single hypothesis: my own immune system was attacking my stomach.

To our surprise, my colonoscopy came back clean. A perfectly healthy colon, better than 95% of colonoscopies of men, according to the gastroenterologist. That ruled out the first concern and worst possible outcome: slow continuous bleeding from colon cancer, or pre-cancerous polyp.

My team had exercised great foresight though, anticipating this possible outcome. In addition to a colonoscopy, they’d ordered an upper endoscopy to be performed at the same time. The combined procedure is a bi-directional endoscopy. Probes would look at my entire intestinal tract, up from below and down the throat.

Additionally, we had several blood biomarkers measured ahead of the procedure to try and pick up on any signals that would give the gastroenterologist guidance for what to look for while doing visual inspections.

Fifteen minutes before the procedure, my blood results returned, finding elevated levels of anti-parietal-cells-antibodies (APCA). They came back at roughly five times the upper limit of normal (103, against a ceiling of 20 Units/mL). It was a positive result confirming the suspicion of AIG being the culprit behind my low ferritin, the other type of gastritis, driven by a bacterial infection, was already ruled out, as we knew I am negative to H. pylori.

Even before this finding, my team had ordered five biopsies to be taken from three regions of my stomach.

The biopsies were the critical piece. Had they not been ordered, the bi-directional endoscopy would have been completed and AIG remained undiagnosed as there were no visual signatures of the condition in my intestines.

Two days later, the results of biopsies came in, showing clear signs of early autoimmune gastritis: early atrophy confined to the acid-producing lining, with the rest of the stomach still spared. My team had anticipated this, methodically tracing every line of evidence.

We now had a formal diagnosis. I have autoimmune gastritis AIG. My stomach is eating itself.

So this was never one problem. It was three, linked to one another: the iron deficiency, the autoimmune gastritis driving it, and the autoimmune thyroid disease alongside it. Iron and thyroid feed each other both ways, low iron impairs the conversion of thyroid hormone into its active form, and an under active thyroid impairs how the body uses iron. Each made the other harder to fix.

Autoimmune gastritis affects an estimated 2–5% of people, and likely more, because it hides and is challenging to diagnose. It's usually silent for years, surfacing only once the stomach has atrophied enough to do real damage: iron deficiency first, then B12 deficiency, then anemia from both, and over a long horizon, raised stomach-cancer risk. In one study of people with precancerous gastric lesions, roughly 18% carried the autoimmune antibodies, and only about 1% had ever been diagnosed.

And the earliest clue, low ferritin, is the one standard medicine waves through. Low iron stores get normalized and rarely investigated at all when anemia hasn't shown up yet. That blind spot is what hid mine for a decade.

The good news: the iron deficiency is now corrected. I received a 1,000 mg Monoferric iron infusion. This was chosen for two reasons after considering multiple formulations. First, it can safely deliver a full dose of iron in a single infusion (1,000 mg), while older options like Venofer require several separate appointments to reach the same total.

Second, certain other IV iron formulations can cause a drop in blood phosphate levels, an important mineral for bones and energy. Monoferric is much less likely to do this, which matters given how closely we track long-term metabolic and bone health parameters.

As mentioned earlier, current medical standards treat AIG as something to be managed, not resolved.

It's worth noting that many of you give me a hard time, inviting me to "live life" and engage in self-destructive behaviors like a "normal person". I'm cool with the playful ribbing. Also, had I not taken care of my health during the past five years, my situation could potentially be very serious.

You too may have a lurking health issue that is undiagnosed and could increase in severity from unhealthy life choices, without your knowing. The absence of symptoms is not the presence of health.

A gentle nudge that minding your health, no matter your situation in life, is good decision making.

My team and I are going to try and solve my AIG. This is how we’re approaching it:

First, routine monitoring keeps the disease in view: ferritin and iron, B12, the pepsinogen I/II ratio, gastrin, and chromogranin A. Gastrin is the dial to watch. If it climbs, the disease is advancing, and the risk of gastric neuroendocrine tumors climbs with it.

Second, we’re doing advanced characterization of the disease. We’ll do a repeat biopsy to read the immune infiltrate, deep cytokine profiling, and T-cell subset analysis, to see which pathways are actually firing.

That testing drives the intervention plan, including the experimental approaches we intend to develop.

+ If gastrin and chromogranin rise: damp the gastrin drive (netazepide) and tighten endoscopic surveillance. If the profile is Th1 / interferon-driven: target JAK/STAT.

+ If it's Th17 / IL-17-driven: target IL-17 and STAT3.

+ If regulatory T cells are failing: rebuild them (low-dose IL-2, induced Tregs).

+ If it's antibody- and B-cell-driven and antigen-specific: engineered cell therapy (CAAR-T).

Which organizes into four tiers, from available today to frontier:

Tier 1, now: protect and support; zinc-L-carnosine, and acid replacement (betaine HCl with pepsin) under physician supervision. This is specific to my case and not something to self-prescribe, especially given the cancer-surveillance considerations above.

Tier 2, target the signaling , JAK/STAT, GSK-3, IL-17, and damp the gastrin drive (netazepide).

Tier 3, reset the cells, induced regulatory T cells (iTregs).

Tier 4, frontier: engineered T-cell therapy (CAR-T / CAAR-T), custom AI-designed antibodies, or synthetic proteins, that can specifically seek out inactivate or destroy the rogue immune cells attacking my stomach lining.

To be clear: there's no approved cure for autoimmune gastritis today. Medicine treats it as something to manage, not solve. Tiers 2 through 4 are investigational preclinical evidence at best, and in several cases therapies that still have to be built.

If you're working on autoimmune gastritis, antigen-specific tolerance, regulatory T cells, or CAAR-T for organ-specific autoimmunity, please reach out.

Modern medicine has normalized too many conditions that erode our health, function, and comfort, shrinking the goal to monitoring and management while a cure is rarely even attempted. Most of these verdicts were handed down decades ago, in an era that predates nearly all of our current tech and science, and they have gone largely unchallenged.

We want to change that. In the age of AI, multiomics, and custom-built DNA, proteins, and cells, no condition should be presumed incurable simply because no one has yet tried to cure it with today's stack.

I’ll end on a personal note.

We fill our days mostly on things that are trivial next to what we ultimately care about. We know, deep down, however, that in the noise of it all, health is easily forgotten until it’s the only thing that matters.

We spend a fraction of our lives truly sober to the preciousness of life. We feel it when someone we love dies, when a child is born, when we come close to death ourselves, or when a diagnosis marks our limit. In those moments, we are sobered, and the rarity of it all becomes self evident. Imagine the existence we’d build together if that clarity didn’t fade.

I wish all of you the very best. Care for yourself, care for others, care for the planet and care for our animal friends. Care for life as it’s the most precious gift there is.

[ben 🏴󠁧󠁢󠁥󠁮󠁧󠁿🏆 @bnwkr]

imagining a 74 year old judge reading this after a long week

[WideBack @0xWideBack]

@mrdoob @dustinodaffer Yo bro, how to see this in dev tools ?

[WideBack @0xWideBack]

The "non invasive" MEG device is 1.5M USD & the size of a room, would love to see if it could fit inside a small helmet soon

[AI at Meta @AIatMeta]

We’re sharing the next major milestone in our non-invasive brain-to-text decoder research: Brain2Qwerty v2.

Building on v1, which was published today in @Nature, Brain2Qwerty v2 is the highest-performing end-to-end pipeline capable of real-time sentence decoding from raw brain signals. It advances beyond character-level performance to decoding words and semantics, enabling accuracy for overall communication.

We believe this research has the potential to make a real difference for the millions of people who suffer from brain lesions or disorders that prevent them from communicating.

🧵👇

[WideBack @0xWideBack]

@zack_overflow I’d just add a headless @orca_build on the VPS, connect it on my mac + iphone via the companion app so my session are persistant everywhere with a (arguably) better UX on mobile.

Can ask claude to set it up for you and if you need help

[WideBack @0xWideBack]

@vydamo_ @blknoiz06 Lock back in my bro

[WideBack @0xWideBack]

A new onchain experiment.

Made by me

[Risk @RiskOnBase]

The concept is simple.

Win and your enemies pump your bag & join your side.

Lose and you'll work for your new Nation.

Value never gets destroyed, it changes hands.

The most exciting adventure is going to start soon.

Powered by @base & @Uniswap

🔔 for early register.

[WideBack @0xWideBack]

With @HeraGamesStudio we first got excited about the capabilities of the chain, opening a lot of possibilites for the GameFi industry.

We worked twice as hard to be ready for the mainnet launch, and the team was supportive at first, giving positive feedbacks on our experiments but also on @TinyWeedFarm .

As we got closer to Mainnet release, we got a radio silence, we kept pushing back to know how are they going to integrate GameFi into the ecosystem and if it was the right time to release…

The team was not supportive and basically ghosted us the day of the TGE, with no further interest in our projects or team.

It has been a huge let down, especially after the initial enthusiasm.

We felt betrayed and left alone, in a market that was already quite harsh.

Glad and also sad that we were not alone in this..

Gmega..

[Shiro ˖◛⁺⑅♡ @shiro57102]

I can’t stand watching people speak with absolute entitlement about situations they really know nothing about. I feel like I’ve stayed quiet long enough.

The constant disrespect, the daily assumption that my silence equals to weakness, it’s become unbearable. Not just for me, but for everyone who actually believes in me and trusts me.
I did not “leverage” Megaeth to mint out Netizens. It was the other way around.
So if you think this, stop being delusional and so incredibly disrespectful, i've had enough.

Let me be crystal clear: the team reached out to me in October and asked if I could launch something on @megaeth because they were “not satisfied with the NFT projects that were already on the chain, in terms of taste and culture”.

It appeared to be very clear since the beginning how netizens could’ve been a great opportunity for the ecosystem to flourish. We were defined as the key to reach a new audience and stop stagnating. We were supposed to be the catalyst and the first brick for a new cultural development and the mint itself was meant to be an event of wider adoption.
My aim was, from the start, to create a space where people could feel part of something for the first time, welcome as their unfiltered selves. Just pure art, pure culture.

I believed in Mega, and I trusted their team with my work, my reputation and my efforts. But it didn’t take long for them to show their real nature.
Mainnet was supposed to launch in November. I worked night and day, without breaks, to meet the deadline, only for the launch to be delayed repeatedly without proper notice (mid-November, late November, early December, and so on, until February). The constant disorganization and inconsistent communication made everything incredibly difficult. We had to coordinate an entire project under uncertainty, which even prevented us from announcing a firm mint date until the very last minute.

I poured my soul into Netizens because that’s what I always do and I thought we all shared the same mission.
Despite all the sugarcoated praise, they were, in reality, not ready to embrace the kind of culture they were asking for, and that we finally brought. Instead of trusting the vision, they chose mediocrity and neutrality. They let people attack me daily, calling me a scammer, undermining everything while I was doing all in my power to make the chain look good. All our efforts felt invisible. Promises were constantly made and broken.
We were used for attention and clout, then quietly discarded every time any existing “community” felt threatened by something superior and actually relevant outside their small bubble.
I was lied to countless times, the team was clearly not coherent or transparent with us and it started being obvious how they were just promising the same exact things to everyone else.
Every time we raised real issues, we were either ignored for days or given empty reassurances that solved nothing.
I had made it clear that I would rather leave than stay where I felt unwanted and unappreciated. I thought they understood. I’m no longer sure they ever did.

Four days before launch, I was still questioning whether the mint should even happen, given the terrible state of the chain.
When I shared my doubts with the team I was told “it’ll be fine because you’re you.”
I was then called delusional for thinking netizens looked to me like the only reason for people to come to mega. Turns out the delusional ones were them.

They couldn’t even sit still and let the magic happen.
Couldn’t trust.
Couldn’t support.
And especially could not protect the few projects they themselves said deserved it, even up to today.
Instead, they enabled the noise, the yes men, the total NPC behavior, all while claiming to be pro-innovation “gen-Zers”.
However, It’s ironic how the same people who watched me get disrespected in silence suddenly praised me after we successfully minted out or after I worked at the EF mandate.
After all these months passed, the team has gone silent, they haven’t done anything for netizens if not disappointing us.
On top of all they’ve acted as if we brought nothing to the chain, turning all my work to dust.
As if Netizens mint didn’t bring an insane momentum, that they were not able to make the most of.
I’m exhausted from taking the blame for other people’s mistakes.

Most atrocious of all, we were never even warned about Terminal shutting down, despite it directly affecting us. Terminal was always presented as our flywheel. We were told to push it hard to our community, it should’ve been our main focus for the future.
Guess what? They just let us down again, empty handed.
Because they lied to us, we ended up lying to our community.

When we questioned about their plans after Terminal ended, they lightheartedly said, “Oh well, we don’t have any plans for NFTs!”
It feels like all my efforts were wasted. I feel fooled and disrespected. They leveraged my reputation and my name for their benefit, without any regard for the consequences on me or the people who trusted me. It’s simple soulless behavior.

To those who still think they can have a word on this, double check your sources. Question what you’re told.
I defended myself when people painted me as the villain for simply pushing back against lies. I was told to stay quiet “to avoid conflict.”
As if the internet wasn’t built on friction, on real time conversation, on calling out what’s broken.
As if I could just pretend all those words didn’t break my heart.

I refuse to waste any more energy trying to save people who don’t want to be saved, as much as I refuse to be disrespected further.
I have more important things to do.
I have to draw.
And that’s irrelevant for so many people
But its so relevant for me.
And hopefully, I can still do something good for everyone
That’s all I’ve always hoped for.

You will not bring me down, ever
If there’s something that will outlive this, is my art. Forever.
Let it be a scar.

congrats on fumbling something genuinely special.
The curse is real. Have fun dealing with the consequences.
@megaeth

[WideBack @0xWideBack]

@durov telegram just need E2E encryption by default and it’s the everything app

[WideBack @0xWideBack]

@himbodhisattva got the same feeling

[WideBack @0xWideBack]

Gonna stop working until Fable is back, talking to Opus4.8 now is like talking to a pure retard….

[Taelin @VictorTaelin]

Futile appeal:

Mythos should not be re-launched.
It should be open sourced.

If it was, that would mark the beginning of an era of unfathomable progress and prosperity to humanity that would make EVERYONE richer, including those at big labs, and the US.

I spent the last hour writing a 10 paragraph long text explaining why that's the case and addressing every single point and counter-argument to it, like security, business, economical impact, China - in ways I know to be true, even though hard to see - but I deleted because it became massive and obviously the people that matter would never read it, let alone have a slim chance of being convinced, given that's the extreme opposite of everything they believe.

But that is a shame, because it is impossible to overstate how much our species would benefit, if that was true. Things would change in ways that seemingly nobody alive understands, particularly these who should. I suppose our monkey brains are just not smart enough to play the right cards here, and, as a civilization, we all lose. Imagine if an alien species found an infinitely deep oil pit, and used it ALL as a hair moisturizer. We'd laugh at them, wouldn't we? Well, that's us with LLMs, right now.

tl;dr way too many people alive today trading a ticket to Mars for a shiny green umber in their phones, and they don't even know that :(