0xgori

#Disruptive technologies research.

[0xgori @0xgori]

@0xDeliriumm i weeas,z And

[Bryan Johnson @bryan_johnson]

Bad news #1:

I have an autoimmune disease. My stomach is eating itself.

Bad news #2:

2–5% of people have this, too. Likely more, because it hides.

Good news:

I'm going to try and solve it. Will share all.

As a kid, I ate sugar cereal, drank sugary soda, and gobbled down fast food. I had a few healthy years in my early 20s but then became a young father of three and began building a business.

Juggling that stress and grind, I let my health slip and gained 40 lbs. Within a few years I’d fallen into a deep, chronic depression.

Somewhere in that timeline, my body began developing an autoimmune process affecting my thyroid and then my stomach lining.

It’s called Autoimmune Gastritis (AIG).

My hypothyroidism got diagnosed when I was 21 years old with a routine blood draw. That enabled me to begin proactive management, supplementing levothyroxine and Armour Thyroid. They are the hormones my body should be producing on its own but wasn’t.

By taking these pills daily, my body was able to operate as though my thyroid was functioning properly. What I didn’t know was that something else was going on inside my body: my stomach had begun attacking itself. But there was no routine test to find out and I didn’t have any symptoms.

I just discovered it in May. I'm unsure how long I've had it. AIG causes irreversible damage: nutritional deficiency, anemia, and over a long horizon, elevated cancer risk. When AIG is discovered today, standard medical care concedes defeat, stating that nothing can be done except managing the condition, no matter how awful or lethal the effects.

Looking back over the past few years, I can now see the early signals we were picking up in measurement but hadn’t connected the dots. For 11 years, I’ve had low ferritin, without anemia. We continually tried to raise my iron levels with food and supplementation but nothing would work.

We chased the obvious solutions first. A plant-based diet means all my iron is the hard-to-absorb, non-heme kind. Hard training, sauna, and hyperbaric oxygen all raise the body's demand for iron. But none of them explained the core failure: despite me taking iron orally, trialing every formulation, and using every timing trick, none of the iron would stick.

What I didn’t fully appreciate until recently is how many stones my previous providers had left unturned. The low ferritin kept getting explained away but not fixed.

I overhauled my medical team earlier this year. It was the rebuild to lay the groundwork for Immortals Care, our $1M a year protocol. With greater capacity, we revisited everything.

On the surface, my low ferritin was easy to dismiss by most standards of care. My hemoglobin and hematocrit were normal. Ferritin measures stored iron, while hemoglobin measures circulating iron, and because the body drains its reserves first to keep hemoglobin normal, you can be fully iron deficient with a perfectly normal hemoglobin and hematocrit.

This is why my low ferritin kept getting dismissed: the numbers that define anemia looked fine, so no one asked why my iron reserves wouldn't refill.

My team pressed on that question. They first turned to a colonoscopy. I was 48 years old and overdue. It was good health hygiene to have while also serving a specific purpose of searching for a hidden source of blood loss such as a polyp or even cancer in my bowels. Either one of those would be an explanation of why the iron kept disappearing.

At the same time, they began connecting the dots. Iron absorption depends on stomach acid, so one theory was that my stomach acid was disrupted. They also knew that thyroid and stomach autoimmunity often travel together, so often that the pairing has a name: thyrogastric syndrome.

Put against my 27+ year history of autoimmune thyroid disease, the pieces pointed to a single hypothesis: my own immune system was attacking my stomach.

To our surprise, my colonoscopy came back clean. A perfectly healthy colon, better than 95% of colonoscopies of men, according to the gastroenterologist. That ruled out the first concern and worst possible outcome: slow continuous bleeding from colon cancer, or pre-cancerous polyp.

My team had exercised great foresight though, anticipating this possible outcome. In addition to a colonoscopy, they’d ordered an upper endoscopy to be performed at the same time. The combined procedure is a bi-directional endoscopy. Probes would look at my entire intestinal tract, up from below and down the throat.

Additionally, we had several blood biomarkers measured ahead of the procedure to try and pick up on any signals that would give the gastroenterologist guidance for what to look for while doing visual inspections.

Fifteen minutes before the procedure, my blood results returned, finding elevated levels of anti-parietal-cells-antibodies (APCA). They came back at roughly five times the upper limit of normal (103, against a ceiling of 20 Units/mL). It was a positive result confirming the suspicion of AIG being the culprit behind my low ferritin, the other type of gastritis, driven by a bacterial infection, was already ruled out, as we knew I am negative to H. pylori.

Even before this finding, my team had ordered five biopsies to be taken from three regions of my stomach.

The biopsies were the critical piece. Had they not been ordered, the bi-directional endoscopy would have been completed and AIG remained undiagnosed as there were no visual signatures of the condition in my intestines.

Two days later, the results of biopsies came in, showing clear signs of early autoimmune gastritis: early atrophy confined to the acid-producing lining, with the rest of the stomach still spared. My team had anticipated this, methodically tracing every line of evidence.

We now had a formal diagnosis. I have autoimmune gastritis AIG. My stomach is eating itself.

So this was never one problem. It was three, linked to one another: the iron deficiency, the autoimmune gastritis driving it, and the autoimmune thyroid disease alongside it. Iron and thyroid feed each other both ways, low iron impairs the conversion of thyroid hormone into its active form, and an under active thyroid impairs how the body uses iron. Each made the other harder to fix.

Autoimmune gastritis affects an estimated 2–5% of people, and likely more, because it hides and is challenging to diagnose. It's usually silent for years, surfacing only once the stomach has atrophied enough to do real damage: iron deficiency first, then B12 deficiency, then anemia from both, and over a long horizon, raised stomach-cancer risk. In one study of people with precancerous gastric lesions, roughly 18% carried the autoimmune antibodies, and only about 1% had ever been diagnosed.

And the earliest clue, low ferritin, is the one standard medicine waves through. Low iron stores get normalized and rarely investigated at all when anemia hasn't shown up yet. That blind spot is what hid mine for a decade.

The good news: the iron deficiency is now corrected. I received a 1,000 mg Monoferric iron infusion. This was chosen for two reasons after considering multiple formulations. First, it can safely deliver a full dose of iron in a single infusion (1,000 mg), while older options like Venofer require several separate appointments to reach the same total.

Second, certain other IV iron formulations can cause a drop in blood phosphate levels, an important mineral for bones and energy. Monoferric is much less likely to do this, which matters given how closely we track long-term metabolic and bone health parameters.

As mentioned earlier, current medical standards treat AIG as something to be managed, not resolved.

It's worth noting that many of you give me a hard time, inviting me to "live life" and engage in self-destructive behaviors like a "normal person". I'm cool with the playful ribbing. Also, had I not taken care of my health during the past five years, my situation could potentially be very serious.

You too may have a lurking health issue that is undiagnosed and could increase in severity from unhealthy life choices, without your knowing. The absence of symptoms is not the presence of health.

A gentle nudge that minding your health, no matter your situation in life, is good decision making.

My team and I are going to try and solve my AIG. This is how we’re approaching it:

First, routine monitoring keeps the disease in view: ferritin and iron, B12, the pepsinogen I/II ratio, gastrin, and chromogranin A. Gastrin is the dial to watch. If it climbs, the disease is advancing, and the risk of gastric neuroendocrine tumors climbs with it.

Second, we’re doing advanced characterization of the disease. We’ll do a repeat biopsy to read the immune infiltrate, deep cytokine profiling, and T-cell subset analysis, to see which pathways are actually firing.

That testing drives the intervention plan, including the experimental approaches we intend to develop.

+ If gastrin and chromogranin rise: damp the gastrin drive (netazepide) and tighten endoscopic surveillance. If the profile is Th1 / interferon-driven: target JAK/STAT.

+ If it's Th17 / IL-17-driven: target IL-17 and STAT3.

+ If regulatory T cells are failing: rebuild them (low-dose IL-2, induced Tregs).

+ If it's antibody- and B-cell-driven and antigen-specific: engineered cell therapy (CAAR-T).

Which organizes into four tiers, from available today to frontier:

Tier 1, now: protect and support; zinc-L-carnosine, and acid replacement (betaine HCl with pepsin) under physician supervision. This is specific to my case and not something to self-prescribe, especially given the cancer-surveillance considerations above.

Tier 2, target the signaling , JAK/STAT, GSK-3, IL-17, and damp the gastrin drive (netazepide).

Tier 3, reset the cells, induced regulatory T cells (iTregs).

Tier 4, frontier: engineered T-cell therapy (CAR-T / CAAR-T), custom AI-designed antibodies, or synthetic proteins, that can specifically seek out inactivate or destroy the rogue immune cells attacking my stomach lining.

To be clear: there's no approved cure for autoimmune gastritis today. Medicine treats it as something to manage, not solve. Tiers 2 through 4 are investigational preclinical evidence at best, and in several cases therapies that still have to be built.

If you're working on autoimmune gastritis, antigen-specific tolerance, regulatory T cells, or CAAR-T for organ-specific autoimmunity, please reach out.

Modern medicine has normalized too many conditions that erode our health, function, and comfort, shrinking the goal to monitoring and management while a cure is rarely even attempted. Most of these verdicts were handed down decades ago, in an era that predates nearly all of our current tech and science, and they have gone largely unchallenged.

We want to change that. In the age of AI, multiomics, and custom-built DNA, proteins, and cells, no condition should be presumed incurable simply because no one has yet tried to cure it with today's stack.

I’ll end on a personal note.

We fill our days mostly on things that are trivial next to what we ultimately care about. We know, deep down, however, that in the noise of it all, health is easily forgotten until it’s the only thing that matters.

We spend a fraction of our lives truly sober to the preciousness of life. We feel it when someone we love dies, when a child is born, when we come close to death ourselves, or when a diagnosis marks our limit. In those moments, we are sobered, and the rarity of it all becomes self evident. Imagine the existence we’d build together if that clarity didn’t fade.

I wish all of you the very best. Care for yourself, care for others, care for the planet and care for our animal friends. Care for life as it’s the most precious gift there is.

[Movez @0xMovez]

Andrew Ng:

"100% of my tasks are now done by AI agents - hype has exceeded my expectations. Loops is next step.

in 3-6 months, everyone will be using self-improving loops. No more prompting."

In a 30-minute talk, Andrew Ng explains how to build self-improving agentic systems from scratch.

Worth more than a $500 agentic course.

[Kirk Borne @KirkDBorne]

Download 698-page PDF eBook…

Everything You Always Wanted To Know About Mathematics* (*But didn’t even know to ask)

A Guided Journey Into the World of Abstract Mathematics, Theorems, and the Writing of Proofs: https://t.co/JLsDOmpP1q

[Metav3rse @themetav3rse]

The teenager who built Oculus VR in his garage, and sold it to Facebook for $2 billion, talks about the most uncomfortable argument about American manufacturing.

"You cannot divorce innovation from the act of manufacturing. You make the stuff, that's where the innovation takes place."

"We were not teaching engineers how to be engineers anymore. We're teaching them how to be high-level design shops that put together a design package that gets sent to the real engineers in China, and they actually figure out how to do the work."

"They don't get 50% more for their dollar. They get like 10x for their dollar. Things that here would take a million dollars, you do there for $50,000, $100,000."

"Their people are just genuinely extremely good. They have the world's best battery engineers, many of the world's best metallurgists, many of the world's best optical engineers."

"The largest laptop manufacturer for the Pentagon is Lenovo, which is owned by China. Their headquarters has a flagpole with the CCP party flag and then the Lenovo logo under it. It's nuts."

PS. Follow us @themetav3rse for latest news on emerging technology and internet culture.

[0xMarioNawfal @RoundtableSpace]

A SENIOR GOOGLE ENGINEER JUST DROPPED A 421 PAGE AI PLAYBOOK FOR FREE

[Anthropic @AnthropicAI]

Our internal data shows Claude is accelerating AI development—a possible path to recursive self-improvement, or AI autonomously building a more capable successor.

It’s happening faster than we thought, and the implications deserve greater attention. https://t.co/OVVPJO7VQx

[Jack @jackcoder0]

Two economists just published a mathematical proof that AI will destroy the economy.

Not might. Not could. Will — if nothing changes.

The paper is called "The AI Layoff Trap." Published March 2, 2026. Wharton School, University of Pennsylvania. Boston University. Peer reviewed. Mathematically modeled.
The conclusion is one sentence.
"At the limit, firms automate their way to boundless productivity and zero demand."

An economy that produces everything. And sells it to nobody.
Here is how you get there.
A company fires 500 workers and replaces them with AI. A competitor fires 700 to keep up. Another fires 1,000. Every company is behaving rationally. Every company is following the incentives correctly. And every company is building a trap for itself.

Because the workers who were fired were also customers.
When they lose their jobs faster than the economy can absorb them, they stop spending. Consumer demand falls. Companies respond by cutting costs — which means automating more workers — which means less spending — which means more falling demand — which means more automation.

The loop has no natural exit.
The researchers tested every proposed solution. Universal basic income. Capital income taxes. Worker equity participation. Upskilling programs. Corporate coordination agreements.
Every single one failed in the model.
The only intervention that worked: a Pigouvian automation tax — a per-task levy charged every time a company replaces a human with AI, forcing them to price in the demand they are destroying before they pull the trigger.

No government has implemented this. No major economy is seriously discussing it.
Meanwhile the numbers are already tracking the curve. 100,000 tech workers laid off in 2025. 92,000 more in the first months of 2026. Jack Dorsey fired half of Block's workforce and said publicly: "Within the next year, the majority of companies will reach the same conclusion."
Nobody is doing anything wrong. Companies are following their incentives perfectly. That is exactly the problem.

Rational behavior. At scale. Simultaneously. With no mechanism to stop it.
Two economists built the math. The math leads to one place.

Source: Falk & Tsoukalas · Wharton School + Boston University ·

[ǝɥǝ⅄ @YeheLiu]

AI will replace PhD >> false
This will replace PhD >> true

[Zhiqiang Shen @szq0214]

🎉🎉🎉 Excited to introduce our recent project FigMirror - a very interesting and useful tool with a simple workflow for making any paper-style figures.

- See a beautiful figure in a paper
- Screenshot it
- Add your own data
- Get a new Matplotlib figure with the same visual style

FigMirror learns the quiet details that make paper figures look polished:

- typography
- spacing
- line weight
- color restraint
- layout rhythm

The key mechanism is Grounded Measurement.

Computer-use AI can point to coordinates inside the reference figure. Code then inspects the pixels, colors, spacing, and layout around those points. This gives the system concrete visual evidence to iterate on.

Our FigMirror draws a candidate figure, compares it with the reference, keeps what works, and improves what still feels off.

Outputs:

- editable Matplotlib code
- camera-ready PDF

It works as both a local Web UI and a Codex / Claude Code skill.

Open source:
https://t.co/zCVM0aAyxp

Try it before your next deadline!

[Atlas @crptAtlas]

Two Sigma and Citadel run billions through ARIMA and GARCH models every day

A researcher just published the complete framework behind how it works

ARIMA and GARCH are 2 of the 5 signal categories in the combination engine I built in the article below

They sit inside the momentum and volatility signal layers

Without understanding what they're actually computing you're running signals you can't validate

Read the 21 pages

Then read the article below and the full 11-step pipeline makes sense end to end

[starmex @starmexxx]

GREG ISENBERG JUST INTERVIEWED A SOLO FOUNDER WHO MAKES $1,000,000 A YEAR BUILDING AI AGENTS FOR REAL ESTATE AGENTS

the agents cost $5,000 to $10,000 a month per client. boring industries pay the most. real estate, insurance, manufacturing, legal. they have money and they hate using ai

he uses obsidian as his second brain because notion can't run agents that actually do work for him

his entire stack: granola, trello, loom, superhuman, asana, codex, hermes, orgo, composio, agent mail. gpt 5.5 by default. claude opus for long coding sessions

99% of the market doesn't know what an ai agent is yet. that's the moat. you don't need to be the smartest. you need to be the one who calls them first

the full breakdown is in the 45 minute video and it's worth every minute

bookmark this and read the article below

[angel @angeldot_]

Anthropic ha publicado un taller sobre cómo construir una empresa solo con Agentes IA.

Agentes trabajando entre ellos, repartiéndose tareas y ejecutando procesos.

Gratis. Del equipo de Claude.

Lo he subtitulado al español.

Si quieres que la IA trabaje por ti, guarda esto 🔖

[priyanshu.sol @priyanshudotsol]

someone wrote a 680 page interactive book on cs algorithms

[sopersone @sopersone]

Claude Code + TradingView = $25K in ONE STREAM

this dude showed how his AI bot trades instead of him

3 hours of full live tutorial from setup to real trades

bookmark this so you don't lose it

[Ronin @DeRonin_]

GTA 6 is about to create more millionaires than most startups

Lock in before release and you could change your life in a single month

Some ideas nobody's running yet:

1. Your own AI-powered RP server

one person with Claude can write what used to take a 20-person writing team

- full character backstories
- mission chains
- gang lore
- fake businesses
- police scanners
- side quests

charge $10-20/mo for server access

10k active players and you're DONE working forever

highest ceiling on this list by a mile

from 100M players it's only hope 0.01% of users

2. Discord bot kits for RP server owners

every RP server on day one needs the same stack:

- whitelist applications
- character bios
- faction management
- in-game economy tracking
- stripe donation flows

build it ONCE in n8n + Claude, sell it $200-500 per server + $50/mo hosting

1,000 servers on it = $50k/mo recurring before breakfast

this is literally the Shopify play for RP servers

3. Clip-to-viral pipeline for streamers

every streamer wants shorts, nobody wants to edit

build this:
- AI watches the VOD
- detects the insane moments
- auto-cuts, captions, uploads to TikTok, Shorts, Reels

sell it to streamers at $99/mo or take rev share

GTA 6 will have 500k+ streamers on day one

math it out

4. The AI meta trader for in-game stocks

Rockstar always builds stock mechanics tied to missions (remember Lester's assassinations)

most players buy emotionally

you'll buy mathematically

run AI analysis on every mission's stock impact, build a predictive model, sell daily trade alerts in a Discord at $20/mo

5,000 subs = $100k/mo from a game mechanic nobody else is modeling

the pattern is always the same

most people will PLAY the game

a small number will BUILD for the people playing the game

only the second group walks away rich

there's a 6-month window where every niche is wide open

first movers own the entire category for 12-18 months before copycats arrive

the window closes the day GTA 6 drops

if you act in the next 48 hours you're competing with nobody

if you wait 2 weeks you're competing with 500 people

if you wait 2 months you're already late

screenshot this. save this. repost it to save a friend's next year

the only people who'll regret tweets like this are the ones who scrolled past them

it's your turn ❤️

[Ruben Hassid @rubenhassid]

How to climb all 4 layers of Claude in one weekend:

(even if you just signed up yesterday)

✦ Level 1: Claude Chat (Saturday morning)

Go to claude .com/download. Install the app.
Pay the $20. Select Opus 4.6 + Extended Thinking.
Connect Slack, Drive, Notion through Connectors.
Stop writing long prompts. Prompt this instead:
"I want to [TASK] for [SUCCESS CRITERIA]. Use AskUserQuestion before you start."

Most people stay here forever.
You're leaving 90% of Claude untouched.
Claude Basics: https://t.co/jw2qdIbLxJ.

——

✦ Level 2: Claude Cowork (Saturday afternoon)

Go to 'Cowork'. Create a folder "Claude-Cowork."
4 subfolders. About me, template, project & outputs
Create about-me .md: what you do, how you do.
Create anti-ai-style .md: words you'd never say.
Set Global Instructions (Settings → Cowork → Edit):
"Always read my files first, never edit my originals, deliver everything to CLAUDE OUTPUTS."

You just killed prompting.
From now on, your prompt is 2 lines + your folder.
Move on to Cowork: https://t.co/uWTpOI3oyE

——

✦ Level 3: Skills + Plugins (Sunday morning)

Open Cowork. Type: "Use the skill-creator to help me build a skill for [your most repeated task]."
Claude interviews you. Answer and be specific.
It generates a SKILL .md. Test it: "When would you use this skill?" If the description is vague, fix it.
Upload: Settings → Capabilities → Skills → Upload.
Now it fires automatically. No slash command.
Install Plugins: Cowork > Customize > Browse plugin

Skills with about-me .md. Skill handles the process.
Voice file handles tone. Two layers simultaneously.
Set up Claude Skills: https://t.co/SAErc3JcLL

——

✦ Level 4: Code + Computer (Sunday afternoon)

Click the Code tab. Create a folder. Connect GitHub
(free account → Settings → Connectors).
Prompt: "Create a GitHub repo named [project]. Code everything. Don't ask for permissions."
Download VS Code. Install the Claude extension.
Turn on "Skip Permissions" to go 100x faster.
After your session, paste this: "Create a CLAUDE .md file with everything you learned about this project." Now Claude remembers your fonts, colors, and structure forever.
Claude code guide: https://t.co/UgE9xBXnm6

Claude Computer: Settings → Desktop app → turn on Browser use + Computer use.
Connect your phone with Dispatch. Text a task.
Schedule a recurring task: left sidebar → Scheduled → write the prompt → pick the frequency.
Claude Computer: https://t.co/ZfjFaaMknc

This is where you stop working inside Claude.
Claude starts working on your computer.

——

Saturday, you were prompting like it's ChatGPT.
Sunday, Claude is running your screen, building your website, & sending you text updates.

That's all 4 layers. In one weekend.

[Elon Musk @elonmusk]

Reinforcing negative neural pathways via therapy or introspection is a recipe for misery. Don’t cut a rut in the road.

[0xMarioNawfal @RoundtableSpace]

OPENCLAW JUST GOT A FULL 5 HOUR COURSE ON BUILDING AND AUTOMATING ANYTHING.