Estelle du Plooy

B Comm Law, Hons Econ, B Biomed Sc, B Health Sc Nut, biochem & nutrition, TBI, ketogenic diet, performance breathwork, longevity nutrition & lifestyle coach

[Oren Gottfried, MD @OGdukeneurosurg]

Immune system one pager

[Estelle du Plooy @4nomad]

Here's a pic from Tim Ferriss 10th Anniversary fan meetup Newcastle, Australia

@tferriss getting together in real life on @getriver_io

[Tom Coughlin @tecoughlin]

Vitamin B2 (Riboflavin) may be an effective treatment for sport-related concussions🧠

A daily intake of 400mg vitamin B2 led to an average recovery time of 10 days after concussion…

…compared to an average of 22 days in the placebo group 👈

Contact sport athletes take note📝

[Estelle du Plooy @4nomad]

@Alan_Couzens Great explanation.

[Estelle du Plooy @4nomad]

A PCSK9-inhibitor (PCSK9i) is a medication that increase the number of docking stations (LDLRs) on the cell membrane being available for docking. This results in fewer Red Buses driving around and hence fewer passengers.

Does this work?

[Estelle du Plooy @4nomad]

Statins also lead to more docking stations, LDLRs being available. With more docking stations there are fewer LDL-buses driving around.

[Estelle du Plooy @4nomad]

hence more LDL-buses driving around.

Statins block the production of cholesterol in the liver cells (for the most part). The liver makes fewer passengers for the Red LDL-buses and there are fewer passengers in circulation.

[Estelle du Plooy @4nomad]

an open docking station.

The liver also makes a special guide for LDL and Lp(a) called PCSK9. The number of docking stations available (LDLRs) is regulated by a controller enzyme called PCSK9. The more PCSK9 there is, the lower the number of LDLRs and

[Estelle du Plooy @4nomad]

Once the LDL-bus is attached to the LDLR, the whole complex is taken back inside the cell and dismantled. The dismantled part can be reassembled at a later stage.

The Red LDL-buses get VIP-access to the docking stations, leaving the Red Lp(a)-buses driving around until there is

[Estelle du Plooy @4nomad]

The liver is constantly making new LDLRs and dismantling old LDLRs. It makes new LDLRs inside the cell and when the cell receives the right signal it will move the LDLR from inside the cell to the outside of the membrane to be available as a docking station.

[Estelle du Plooy @4nomad]

them back to the liver.

The liver cells make docking stations on its cell membranes called LDL receptors (LDLRs) for Red LDL-buses to be docked and then be taken up inside for overnight parking. Hence taking LDL-buses out of the tunnels.

[Estelle du Plooy @4nomad]

while others get an ApoA sticker and are called Lp(a). The Lp(a) bus drivers tend to be a bit reckless and bump into the walls of the tunnel (arteries) causing damage.

The liver also makes big Blue Buses (lipoproteins) called HDL to collect tired passengers from cells and take

[Estelle du Plooy @4nomad]

This new, full bus is called VLDL. The Red Buses leaves the liver and drives around in the tunnel (arteries) to deliver passengers to their destinations.

As the passengers get off the big Red Bus, the bus gets smaller. Some Red Buses gets an ApoB sticker and are called LDLs,

[Estelle du Plooy @4nomad]

I have attempted an analogy for #cholesterol and would love feedback.
Would appreciate it if you have a spare second - maybe
@OxPL_apoB or @PeterAttiaMD

The liver makes big Red Buses (lipoproteins) to carry passengers to cells. The passengers are cholesterol and fat (TGs).

[Estelle du Plooy @4nomad]

@Paddy_Barrett @doctorinigo Great summary

[Estelle du Plooy @4nomad]

@DrSianAllen I did fencing when I was at uni (a long time ago) - it was a standing joke amongst us that fencers are the most unfit from a respiratory-cardio point of view.
They have good muscle endurance though

[Estelle du Plooy @4nomad]

@Joseph_Watso @FloridaState @FSUResearch @FSUFaculty @fsucehhs @FSUISSM @APSPhysiology @AJPRegu @hubermanlab Thank you for posting. Research like this is valuable to me as a breath coach. Will add this to my list of papers with similar conclusions. You may find Guyenet 2014 interesting if you are not already familiar. https://t.co/4iCbF8O3Vk

[Estelle du Plooy @4nomad]

Great thread by @stevemagness
Micromanaging our kids every experience and 'protecting' them from perceived dangers limits their capacity to problem solve & increase risk of mental health problems

[Steve Magness @stevemagness]

Only 25% of kids regularly play out on their street.

This number used to be 80%.

Adults have ruined play.

Why? Fear & Safetyism.

When we see threats everywhere, we default to avoid and protect mode.

And it's ruining our kids mental health. Here's why:

[Estelle du Plooy @4nomad]

@CaloriesProper Wow! I am more & more intrigued by photobiomodulation.
I have a kineom move - and it is the only thing that works for my ankle - suspect OA but nor sure

[Coleman Hughes @coldxman]

In light of the grotesque attack on Israel by Hamas, I want to repost my conversation with reknowned Israeli historian Dr. Benny Morris.

Already we are hearing apologists claim that Israel had this coming––that 75 years of colonial oppression is bound to result in an equal and opposite reaction.

Most of the people who say this have no understanding of the relevant history. That is why I did this episode with Dr. Morris: we walk systematically through the history and ethics of the Arab-Israeli conflict from the 19th century to the present. Please listen to the episode with an open mind and share it with your friends.

https://t.co/yNNPq88lng