James ジェームズ

七転び八起き
M.S. Pharmaceutical Sciences 💊
B.S. Biochemistry: Medical Chemistry ⚗️
B.A. Japanese Studies: Zen Buddhism 🙏

[James ジェームズ @5HT2andJames]

Psychedelic substances are not suitable for everyone. However, for those who choose to use them, understanding and adhering to set and setting parameters is essential for maximizing harm reduction.

[James ジェームズ @5HT2andJames]

My friend sent me this photo from a psychedelic conference and it made me chuckle

[James ジェームズ @5HT2andJames]

Chatting w/ some friends about our favorite psychoactive substances. Mine is, without a doubt, caffeine. To appreciate the character of the bean, I drink it only over ice. As the ice melts & gradually dilutes the coffee, the flavor profile evolves, revealing different layers! ☕️

[James ジェームズ @5HT2andJames]

To celebrate a friend’s birthday we went to a cigar bar. This was my first time & I was struck not only by the complexity/variety of cigars, but the diversity of users.
The polypharmacological interactions between alcohol + nicotine, or mixing downer+upper makes me curious 🤔

[James ジェームズ @5HT2andJames]

I deeply respect those who ignore the hype and ask difficult questions.

[BryanRoth @zenbrainest]

I find myself in the same camp as Nora--I have been skeptical for decades regarding the potential therapeutic actions of #psychedelics The pioneering work of Griffiths, @RCarhartHarris @ProfDavidNutt and others changed my mind.
That being said...I still am concerned that the 'cures' (or long-term benefits) will prove to be transient for most as well as:
--After 6 months or so when the effects wane ... will 'booster sessions' be needed and will they work?
--What will be the frequency of adverse events/psychosis/HPPD in the general population?
--Will it be possible to safely administer #psychedelics to individuals on SSRIs? (so far, so good)
--Age/Sex/Ethnicity--still no answers

[James ジェームズ @5HT2andJames]

Saw this at a local goodwill and it saddened me that the requirement to be "friends" required Prozac an SSRI anti-depressant. Or am I reading this wrong?

[James ジェームズ @5HT2andJames]

@Psyched_Alpha Absolutely incredible work. Suicidal Ideation trials are tough in general, and I hope psychedelic use with the correct set and setting can offer relief.

[James ジェームズ @5HT2andJames]

@RogerSeheult @healthnutritipz Dr. S- Thank you for your comment and I agree as many with alcohol use disorder typically come with a laundry list of issues.

[James ジェームズ @5HT2andJames]

@getsmoothee @Drug_Researcher I wouldn't be so quick to say zero medical value as nicotine may act as a neuroprotective agent against Parkinson's disease.

[James ジェームズ @5HT2andJames]

@Josh__Hardman Great question, but it depends on how you define a psychedelic.

[James ジェームズ @5HT2andJames]

@Drug_Researcher @DrMorisano How do you think psilocybin’s effects on learned associations/ salience processing would differ between a traditional cigarette smoker (Marlboro/american spirit) and a bubblegum vape user, given their very different reinforcement patterns despite both involving nicotine?

[James ジェームズ @5HT2andJames]

@ArneEichberg Thank you for sharing! I hope you have a transformative experience

[James ジェームズ @5HT2andJames]

Psychedelic substances are not suitable for everyone. However, for those who choose to use them, understanding and adhering to set and setting parameters is essential for maximizing harm reduction.

[James ジェームズ @5HT2andJames]

@Fractalmeatbag @RCarhartHarris I deeply appreciate your perspective and applaud you for quitting smoking. To your point, I also believe psilocybin has the potential to help many with smoking cessation

[James ジェームズ @5HT2andJames]

@RCarhartHarris I long for insights 🙏

[James ジェームズ @5HT2andJames]

@ArneEichberg @RCarhartHarris Arne, I couldn't agree more!

[Robin Carhart-Harris @RCarhartHarris]

Very big paper dropping this Tuesday… watch this space… tell your gran… tell your neighbours… “Human brain changes after first psychedelic use” - Nature Communications…

[James ジェームズ @5HT2andJames]

本当の旨味の真髄は、新鮮な寿司を日本酒と一緒に、少しのわさびと醤油で味わうことです。
The true essence of umami is enjoying fresh sushi with Japanese sake, accompanied by just a little wasabi and soy sauce.

[James ジェームズ @5HT2andJames]

@Liv_Boeree People will always find a way to consume a psychoactive substance; even through times of prohibition.

[James ジェームズ @5HT2andJames]

Japan’s psychoactive substance culture is fascinating! Due to strict regulations, nicotine, alcohol, and caffeine dominate. Tobacco use is still permitted in some cafés. Moreover, if 飲み放題 (all you can drink buffet) existed in the US, hepatology would be in great demand 🍻

[James ジェームズ @5HT2andJames]

@ExistWell How serendipitous, I am in Tokyo right now!