AD3 𝕏

I dream of the day ! That i will be able to remember that #Alzheimer once existed…..#ENDALZ 💜 #caregiving #father #hope

[Kerri Pouliot @KerriLPouliot]

Our Tesla cyber truck was vandalized this weekend in NH. While staying at our hotel, our vehicle was keyed within an hour of arriving. James “Jim” Pelis & chuck smith either didn’t know or didn’t care that they would be recorded. Charges pending! Class A felony In NH.

[AD3 𝕏 @AD3ENDALZ]

@HenrikZeberg 😂

[Matt Nachtrab @MattNachtrab]

Post Trial Survey and Patient Advocacy for Continued Access to Simufilam

Something isn't making sense with the $sava trial results. If you or a family member were in the trial and you would like to help advocate to get access to the drug, please fill out this form. You can help us make certain the data represents the ACTUAL trial results.
Caregivers, clinical site investigators, all reported the drug was working but the data did not represent what was said.

The safety profile of the drug is incredible and many families and medical professionals at the site believe the drug works. Just because it is at a small biotech does not mean it should not have a legitimate chance to help with #alzheimers

Anything you can do at clinical trial sites to register patients will help. If you are an advocate for the drug, call the sites and suggest they send patients to this link with this QR code. If you want to help, maybe make a printable image they can hand out. Let's get as many of the 2200 patients registered as possible.

I am not sure if we will be able to drive change, gain access, but if we don't try we never will know. We will use your collective voice to advocate to Cassava and the FDA.

I do not recommend buying the stock in support of this effort. This is about the patients and the families.

https://t.co/FN2FOAPdSP

This QR code takes you to the form too.

[AD3 𝕏 @AD3ENDALZ]

$SAVA

SAD DAY …. For Alzheimer patients and people who’ve had hope of success of #SIMUFILAM

Let’s pray that treatment will be soon made available and that a breakthrough be made in this horrible disease

🥺

[AD3 𝕏 @AD3ENDALZ]

LOL @MartinShkreli … come on pharma BRO …
Telling your ppl to SHORT NOW ,,,, $SAVA
You can’t neither on ROBIN HOOD and or IBKR ?…
No one knows what’s up tomorrow i think it will be good news
#ALZHEIMER PATIENTS and SAVA believers needs it

[AD3 𝕏 @AD3ENDALZ]

@TheRealupnDown Would definitely be a SAD DAY ,,,, for many :( including me …..
I hope it doesn’t. I doubt that SAVA would of announce BAD NEWS on SUNDAY NIGHT …..for a MOnday morning on thanksgiving week… $SAVA = HOPE of SUCCESSFUL TREATMENT

[AD3 𝕏 @AD3ENDALZ]

$SAVA

… CONF CALL IN THE MORNING W/KOL + LANDEN + HENDRIX TO DISCUSS TOPLINE DATA FROM RETHINK ?

-PARTNERSHIP?
-BUYOUT ?
-NEW INDICATION …. ?

WEIRD TIMING but EXCITING TIMES

[AD3 𝕏 @AD3ENDALZ]

Uhmmm interesting …$SAVA $MDGL

[PK_Fund @PK_Fund]

$SAVA When MDGL announced the positive ph3 results for resmiterom in MASH, they issued PR on Sunday Dec 18 4 pm EST to announce a corporate update the following day Dec 19 pre market. The rest is history. Could this be the same?

[Matt Nachtrab @MattNachtrab]

$sava just sent a notice they have a corporate update at 8am tomorrow morning. I’m thinking it is regarding the new hire from Biogen, but that’s an odd reason to hold a live conference for.

https://t.co/j3kc7geEwJ

[Matt Nachtrab @MattNachtrab]

@TEXTILE_FIBER @J55612435 @RobertDurant7 I am building the connections now to hold those involved with slowing $sava down accountable. Most importantly to get investigations of the government actions taken to investigate cassava and associated parties.

[AD3 𝕏 @AD3ENDALZ]

@DueDoctor No… just the usual #F U FORMATION 😂
$SAVA

[Matt Nachtrab @MattNachtrab]

The simufilam Phase 3 trials for #Alzheimers may have patients in earlier in the AD progression than expected - let me explain...

Cassava Sciences, $sava, allowed patients that are 16 to 27 MMSE into the trial. 16 to 20 are considered Moderate and 21- 27 are considered Mild.

To understand the points I am about to make you need to understand the analysis that $lly performed on their donanemab Trailblazer ALZ 2 trial. They accepted patients with MMSE between 20 and 28, but performed amyloid AND tau PET scans to confirm Alzheimer's disease in the brain.

Plasma pTau181 was used for screening in the Phase 3 Cassava trials. Plasma pTau181 detects AD progression earlier that PET scans. In other words there could be patients that Trailblazer PET scan eliminated because they were earlier in disease, but pTau181 would catch.

Something else that Trailblazer taught us was MMSE is not nearly as good at predicting disease state as PET pTau or Plasma pTau tests. The higher tau cohort performed significantly worse at 18 months with a 11.08 adas-cog13 decline vs 4.9 in the low and medium. For a 2 point difference in average MMSE, according to the ITO study of ADAS-Cog declines, you would only expect a 1 point different decline at 18 months.

MMSE really should not be used alone to determine disease state. Trials should really use plasma pTau tests to screen. pTau is a much better predictor of true disease progression than MMSE.

All of this has two impacts to the phase 3 trial of Cassava:

1. If we believe milds do better on simufilam, then the pTau181 scan will produces a milder patient base than one that is confirmed with PET.

2. The 16 to 27 MMSE allowance may still produce a more moderate base of patients, but when balanced with the earlier disease screening of pTau181, I think the overall population of RETHINK will decline ADAS-Cog12 at a slower rate than I originally thought. After this analysis, I think the ADAS-Cog12 placebo decline will be 4.25 or less. The trailblazer placebo for their total population declined at 4.45 at 12 months.

The ADCS-ADL is the second primary endpoint for Cassava. Based on what patient families say, I feel comfortable about them out performing placebo. The issue I am finding is that there is not much available research for performance. One that I found found a population with MMSE of 21 (Refocus is 21.7) declined ADCS-ADL by 6.7 points [1].

So I am forecasting RETHINK placebo for change in ADAS-Cog12 of 4.45 or lower and change in ADCS-ADL of 6.7 or less. I believe the treatment arms will be near zero for both. A conservative estimate is they cut both declines in half, so 2.25 and 3.34. Those are my bets... what do you think they placebo and treatment performance will be?

https://t.co/x140YHeWOX

[AD3 𝕏 @AD3ENDALZ]

@MartinShkreli Nice panic mode Tweet…. On $SAVA
🚨

[AD3 𝕏 @AD3ENDALZ]

@MWM76 Lol of course you dont , #nakedshortygettingwrecked
And how is your $TSLA short doing ?

Bye bye 👋

[AD3 𝕏 @AD3ENDALZ]

@MWM76 Lol 😂 desperate tweet/post

[AD3 𝕏 @AD3ENDALZ]

$SAVA wow!! This is a major league #HIRE
🚨👏🚨👏

[Matt Nachtrab @MattNachtrab]

$sava just hired Landen Jaren. She has 7 years at biogen and was the Head of Early Alzheimer's Disease. She was at Pfizer as
Director Clinical Lead Pfizer Clinical Research and Development. Early AD trials incoming.

[Kalon @Kalonshaka]

$SAVA @elonmusk @RobertKennedyJr @VivekGRamaswamy FINALLY GOT MY “BLUE CHECKMARK (took 3 days BTW) because I like what you and your team are doing. Let’s see how this goes as I try to bring attention to Cassava Sciences (appended link below) and the CORRUPT WALLSTREET FORCES against Alzheimer’s innovation…

With the 4 year long Short and Distort against Cassava Sciences (and countless other companies) by CORRUPT WALLSTREET, and with wallstreet’s use of the weight of our government as well as our Courts, the SEC and DOJ, and the use of paid “FUD consultants” and paid legacy media propaganda (NYT, WSJ, Science, STAT), along with their failure to delivers, naked shorting, options manipulation, millions of shares borrowed each day, all in order to try to stop a company that’s is attempting to develop a safe drug for the hardest to address healthcare unmet indication on the planet. This completely proves to me that our degenerate US stock market is on par with second/third world stock market corruption, which makes our US stock market a joke under current SEC.

There are only two sell-side analysts (with zero buy side analysts) covering $SAVA weeks out from Phase 3 and very rare positive media coverage, all consistent with this vast Wallstreet COLLUSION and they have driven this FALSE narrative against Cassava. Wallstreet can’t bear the thought of buying the majority of share supply from thousands of retail investors (who have out smarted them) and would rather steal, lie, and deceive and lawfare in order to destroy $SAVA rather than buy back their shorted shares and payback their illicit debt…it’s as simple as that!

I have summarized the historic discovery Cassava Sciences has made (@joerogan @bryan_johnson @LoganPaul #Longevity #FLNA) appended post below-MUST READ, and many other posts therein) and we are only weeks out from Phase 3 Alzheimer’s Rethink study data readout! It’s not hyperbole to state that no other biotech or pharmaceutical company has discovered and developed a therapeutic targeting the biological fate of cellular Filamin A (FLNA), and Cassava Sciences is the first to do it, This is a FACT! This will impact many diseases that are in mild-moderate stages, not only Alzheimer’s!

Wallstreet has tried to stop Cassava’s Phase 3 Alzheimer’s program and have failed. The implications of targeting FLNA with a potent small molecule therapeutic will shock the world and Wallstreet’s corruption will be further laid bare for everyone to see.

[AD3 𝕏 @AD3ENDALZ]

@f1_racing_fan @LogarithmicDis 😂😂😂😂😂😂😂😂😂