Kalon

Years of R&D experience (not an advisor of any kind, just my opinions based on heavy research)

[Kalon @Kalonshaka]

$SAVA @elonmusk @RobertKennedyJr There is NO STOPPING SCIENCE no matter how hard CORRUPT WALLSTREET (and we all know who these disgusting criminal Hedgefunds are) try to stop Cassava Sciences by using the recent weight of the government by the bogus SEC actions against $SAVA and the bogus DOJ action against one of the co-inventors, Dr. Wang…. https://t.co/5lSViPAPBD

I have posted about this criminal short and distort here.. https://t.co/2JusWQPFO4 and here.. https://t.co/j43M9S0yW7 and here.. https://t.co/Oluhas681M

After Cassava Sciences reads out their phase 3 rethink study by EOY, I have very little doubts that it will replicate all the data summarized here…https://t.co/jgZfZ3T7zV and here…https://t.co/pxcntpaPPT

And Cassava has recently said that they are also pursuing additional biological studies with Simufilam as further support (though this is not really needed after phase 3 successful readout imo) AND they are planning and gearing up production of Simufilam to address the gargantuan Alzheimers market!

This continued collection of data will further open up the research flood gates into the FLNA pathways and FLNA implications is no many diseases and Cassava has the only drug therapeutic approach to address this pathogenic FLNA pathway. I have posted about this on numerous occasions and different topics and my speculated models and summaries are all based on existing science that no one has articulated before. I summarized these here:

1. The supporting evidence of different (altered) FLNA confirmations here based on FLNA phosphorylation… https://t.co/ld2bwFvo5T
2. The extremely potent pico-molar/femto-molar biological activity (confirmed by outside researchers) of simufilam in comparison to most other drug-protein interactions…https://t.co/Bt0Q4esQBW
3. The connection of FLNA to atherosclerosis.. https://t.co/NHAtSEcyNd
4. The connection of FLNA to NASH…https://t.co/ah4GqJ6hlq
5. The connection of FLNA to integrin/inflammation activation…https://t.co/W9bmnqpaLT and …https://t.co/4hAFBlDcDp and .. https://t.co/AnEzjZsJ4d
6. My ALL ROADS LEAD TO ROS post…. https://t.co/KPE2CKoTSV
7. My direct connections of APOE gene mutations to ROS-Hypoxia.. https://t.co/1d3odMDGBV and here…https://t.co/4qo0gRQjfx
8. Implications to chronic age related diseases.. https://t.co/CkRrPvLIW3
9. My hypothesis of FLNA impact to “MILD” Diseaes….. https://t.co/oEJ1K5uHZO
10. FLNA in Cancer…https://t.co/6hlbnyqe0O
11. Links therein and others…

Corrupt Wallstreet that started this short and distort against Cassava over 3 years ago were completely oblivious to all this and even Cassava to this day is playing down what they have discovered IMHO! I’ll repeat, the WORLD changes after Phase 3 readout and there’s NOTHING STOPPING SCIENCE!

[Kalon @Kalonshaka]

$SAVA @elonmusk The more I educate myself around K-RAS and gain additional context, the more ecstatic I become for the very real probability of simufilam in cancer and even coming more to the realization that FLNA is a very important piece of the puzzle.

Of course my model already captures it, originating from ROS/hypoxia then KRAS-kinase-FLNA-integrin etc, which I have posted on multiple times impacting almost all diseases (not only Alzheimer’s and cancer), https://t.co/1NhFfbEfWz but the immediate implications for cancer are more eye opening than even I had estimated. Let me explain.

I find that pictures speak a thousands words , so let me start off with this very nice picture on the web.

This picture showcases a lot of the biological paths but let’s focus on the left side. Several of these I have previously posted about, for example integrins, RTKs, GTP, RAS, K-RAS controlling PI3k pathway and MAPK pathway, etc. but look how all the “business” occurs at or near the cell membrane, where FLNA resides. From my posts we know that FLNA (and FLNA phosphorylation) interacts and signals a wide variety of known and well established moieties, from Integrins, to RTKs, RAS, GTP, Kinases, STAT3, FLNA-CT which translocates HIF into nucleus, calpains, etc…the list goes on and on. And we know that many cancer publications have spoken highly about the potential of FLNA as a therapeutic target, but those researchers have not found interventions to enable a cancer approach through FLNA.

IMHO Cassava has now found this very likely novel drug candidate for FLNA for cancer, it’s simufilam and other Cassava’s related drugs targeting FLNA fate, i.e. Cassava’s technology platform. I am convinced that simufilam targeting the FLNA phosphorylation will be extremely meaningful to cancer therapies in combination or as a mono therapy given the indirect activity against RAS (through potent FLNA phosphorylation reduction activity) and the feedback loop that I have postulated.

What’s even more exciting to me that unlike RAS targeted approaches that are prone to drug resistance through high rates of mutations of the RAS genes, FLNA target approach by-passes this drug resistance issues because of the criticality of FLNA signaling to the cell. So simufilam or other FLNA binders can be used potentially as a mono therapy or in combination with existing cancer drugs to increase their effectiveness or help these drugs overcome drug resistance as the University of Milan eloquently had shown with pituitary tumors using simufilam with octreotide.

We are watching innovation in real-time, Pharma and the world changes after Alzheimer’s Phase 3 rethink readout by EOY IMHO!

[Kalon @Kalonshaka]

@davidasinclair And maintaining order is surprising so simple and elegant….

[Kalon @Kalonshaka]

@davidasinclair not drift….

[Kalon @Kalonshaka]

@davidasinclair Half the story…

[Kalon @Kalonshaka]

@davidasinclair Fibrosis, senescence, IR, immune system changes…..yours is just half the story.

[Kalon @Kalonshaka]

@davidasinclair Agree on the insane variability….and There are many other promising therapeutics that increase LTL with more simple MOA, which haven’t gone through RCT trials…for a reason.

[Kalon @Kalonshaka]

@agingroy 🤔

[Kalon @Kalonshaka]

@foundmyfitness Should be super high on list, dig deeper into the science. The lack of clinical data is for a reason…

[Kalon @Kalonshaka]

@BiluHuang Just a symptom…

[Kalon @Kalonshaka]

“The problem with your motivated reasoning here is it has been used for every supplement for 100+ years…most of which have been proven to be useless”

“No motivated reasoning” nope just following the many orthogonal scientific studies conducted all trending a consistent message.

“Proven useless”. Who’s the motivated one?

The industry is riddled with anti-competition

[Kalon @Kalonshaka]

The problem is that no pharma or other sponsor will do studies to “prove” efficacy given the economics and anti-competition of the industry, and this applies to other “anecdotal” cheap therapies, which there are a plethora of. if you look at the basic science expts and animal models with relevant dosing, and data collected, which is not cost onerous to do, one see‘s a vast amount of info that supports the mechanisms behind these interventions. The system establishing proof in healthcare is simply not pragmatic or feasible unfortunately.

[Kalon @Kalonshaka]

Because it’s doing more than simply a modest reduction in BP. How do we know? it’s tied to the biology of how those reductions occurs, certainly worth risk given how widely it’s been used. Is it proven? of course not. But put pieces together and you get a compelling benefit/risk

[Kalon @Kalonshaka]

@DrIngold “Its primary reproducible impact is lowering blood pressure a few points”. This is in fact the reason why it works if one understands the cellular biology!

[ScienceGuardians @SciGuardians]

🚨 Compromised / Reckless Journalism — One of the “6 Plagues” Corrupting Academia

In his Lindau 2025 lecture, @NobelPrize Laureate @Stanford Professor Thomas C. Südhof explicitly references an article published in Science magazine.

The author? Holly Else.

Who is Holly Else?

We previously exposed her conduct in April–June 2025, when she deployed a series of maneuvers — including the use of a fake email address — in an apparent attempt to prevent the exposure of the fake “science integrity consultant” Elisabeth M. Bik, whose activities we have documented as years of misconduct carried out under the guise of “research integrity,” at that time leveraging the @NatureNV brand.

Her efforts were futile — and ultimately played directly into a structured and strategically executed plan by the @SciGuardians Legal & Investigative Team.

📌 Full April–June 2025 exchange between Holly Else and ScienceGuardians™:
👉 https://t.co/VovRGET75n

📌 Full Q&A (unaltered, unedited, preserved exactly as delivered on 2 May 2025):
👉 https://t.co/v3MpS7tkV7

Now, returning to her earlier role:

On 1 May 2024, under the leadership of @ScienceMagazine Editor-in-Chief Holden Thorp, Holly Else authored the article:

“Nobel-winning neuroscientist faces scrutiny for data discrepancies in more than a dozen papers.”

This article did not emerge in isolation.

In September 2025, we cast much-needed light on what we identified as a preplanned dossier-construction operation — a coordinated smearing and defamation campaign executed by the perpetrators of the PubPeer “PubSmear” Network Mob:

👉 https://t.co/qCmyQpameg

With the masks now off and the façade collapsing, we urge the academic community to carefully examine this Science magazine article. Link in the first comment.

It contains multiple layers of critical signals and information — inadvertently revealed — that expose how such narratives are constructed, amplified, and legitimized, as well as the actors behind them.

Compromised journalism is not incidental. It is instrumental.

It plays a central role in enabling, scaling, and legitimizing coordinated attacks within the academic ecosystem.

And yes — understanding the role of compromised journalists is key to unraveling the architecture of these complex mob networks and their agenda.

@SciGuardians
🔱 Empowering Researchers. Restoring Integrity. Eliminating the Plagues Corrupting Academia. 🔱

[ScienceGuardians @SciGuardians]

🚨 Holden Thorp, Editor-in-Chief of @ScienceMagazine, boasts about it being a 'non-profit journal.' Facts: Its parent org, @aaas, pulled in $129M revenue in 2024 (mostly publishing fees/subs/ads) and holds ~$127M in total assets. Non-profits can amass fortunes (reinvested, not to shareholders), but is this truly non-profit or tax-exempt empire-building?

Much more exposed in this 4:27 minute clip.

🧵 Read the attached thread on the Holden Thorp Puzzle, which exposes his enabling of smearing campaigns against high-profile members of the academic community.

[ScienceGuardians @SciGuardians]

🚨 Exposed: The Same Playbook — From PubPeer "PubSmear" to Wikipedia 🚨

⚠️ As revealed by Larry Sanger, Wikipedia’s own co-founder, the platform maintains blacklists determining which outlets can be cited — silencing dissent and protecting establishment narratives.

But this bias is no accident. The PubPeer “PubSmear” Network Mob has deeply infiltrated Wikipedia as well. After carrying out their four-stage smear operation — fabrication ➡️ defamation ➡️ legitimization ➡️ formalization — the final act is amplification through biased outlets and their compromised journalists, culminating in manipulated Wikipedia pages targeting their victims.

🧩 The pattern is unmistakable. The same actors. The same agenda.
To control the scientific record, erase independent voices, and dominate academia.

⚠️ The time for biased, easily manipulatable platforms such as PubPeer “PubSmear” and Wikipedia is over.

🎥 Watch how the PubPeer “PubSmear” Network Mob operates — and who funds it, why they are rattled, and how the future of post-publication peer review is ScienceGuardians™.👇

🔱 @SciGuardians
Accountability. Integrity. Empowerment.

@SecKennedy @DrJBhattacharya @IRSnews @ftchina @RWMaloneMD @TuckerCarlson @JasonJournoDC @DailyCaller

[ScienceGuardians @SciGuardians]

🚨 The real question is not how many retractions we’ve enforced. It’s how many truths we’ve silenced along the way.

📌 Read the full article by @J_Strachan_Edit and Frank van Geel, published in The Analytical Scientist (@tAnaSci):
🔗 https://t.co/ZZsZptylSl

[ScienceGuardians @SciGuardians]

OFFICIAL ANNOUNCEMENT

ScienceGuardians™ — Restoring Power to the Academic Community and Eliminating the Plagues Corrupting Science

ScienceGuardians™ exists to serve and empower the true backbone of science: the more than 20 million authors, reviewers, and editors whose intellectual labor sustains global scientific progress, yet who have been systematically exploited, structurally disempowered, and economically excluded for decades.

Science does not belong to publishers.
Science does not belong to foundations.
Science belongs to those who create it.

Authors produce the knowledge.
Reviewers safeguard its validity.
Editors ensure its integrity.

Yet these indispensable contributors receive literally zero economic participation in the multibillion-dollar industry built upon their uncompensated labor.

Instead, parasitic intermediaries operating under the label of “academic publishers” have constructed extraordinarily profitable business models by extracting free intellectual labor while retaining nearly all financial value.

Major academic publishing corporations—including Elsevier, Springer Nature, Taylor & Francis, Wiley, MDPI, and Frontiers—generate billions of dollars annually in revenue and maintain profit margins rivaling or exceeding those of many of the world’s most successful technology companies.

They achieve this not through superior innovation, but through structural deprivation of the very stakeholders upon whom their entire business depends.

Authors surrender copyright ownership of their work without compensation.
Reviewers provide expert evaluation without compensation.
Editors assume enormous responsibility without proportional compensation.

Publishers then monetize this uncompensated labor by charging both the public and the academic institutions funded by taxpayers to access the same work created freely by researchers.

This structural exploitation created an ecosystem of profound imbalance—an ecosystem within which additional systemic plagues were able to emerge and proliferate.

The Structural Reality: Individuals and Foundations Are Not the Center of Science — The Academic Community Is

Science and the academic community do not depend on any individual benefactor.
Science and the academic community do not depend on any foundation.
Science existed before them, and science will exist after them.

The academic community itself is the foundation of science, and does not require external control or oversight to correct itself. It is a dynamic system fully capable of self-correction when properly empowered.

No individual actor, intermediary, or financial entity is structurally important relative to the collective force of millions of researchers whose work sustains scientific progress.

The Plagues Corrupting Academia

ScienceGuardians™ has identified six systemic plagues that have metastasized within this disempowered environment:

1. Predatory Publishers and Journals
2. Predatory Practices by So-Called Legitimate Publishers and Journals
3. Paper Mills
4. The PubPeer “PubSmear” Network Mob
5. Predatory Conferences
6. Reckless and Compromised Scientific Journalism

These plagues do not exist in isolation. They operate symbiotically, exploiting the structural vulnerability of researchers while shielding themselves behind institutional legitimacy and financial backing.

Among these, the PubPeer “PubSmear” Network Mob represents one of the most deliberately constructed and systemically harmful forces.

This network consists of approximately thirty individuals, including non-academics and low-profile actors who have exploited the disempowered academic ecosystem for personal and institutional gain.

Operating under the public guise of “research integrity,” this network has engaged in coordinated reputational attacks, targeted harassment, narrative manipulation, and systematic exploitation of structural asymmetries within academia.

Major enabling infrastructure for this ecosystem—including the PubPeer Foundation and Retraction Watch—has received sustained financial support through Arnold Ventures LLC (formerly the Laura and John Arnold Foundation).

ScienceGuardians™ acknowledges that philanthropic contributors may not always have full operational visibility into downstream conduct enabled by their financial resources.

Accordingly, we extend John Arnold and Laura Arnold the professional courtesy of assuming that their financial resources may have been deployed without their full awareness of downstream operational consequences.

However, structural responsibility cannot be separated from financial enablement.

Financial enablement carries an obligation of oversight.
Financial enablement carries an obligation of accountability.
Financial enablement carries an obligation of correction when harm has been enabled.

Opportunity for Transparency, Audit, and Public Accountability

ScienceGuardians™, on behalf of the academic community, formally invites Arnold Ventures LLC to conduct a comprehensive internal audit of all funding relationships connected to entities operating within the post-publication and research integrity ecosystem.

This audit should determine:

• How financial resources were deployed
• Whether those resources enabled systemic harassment or reputational manipulation
• Whether corrective actions are necessary

ScienceGuardians™ further invites public disclosure of audit findings and appropriate corrective measures, including public clarification and acknowledgment of harm where applicable.

A reasonable timeframe for such review and disclosure is fourteen (14) days starting from the date of this official announcement.

This notice is issued in good faith and as a professional courtesy to enable transparency and correction.

For clarity and factual precision, the Connection Web referenced in our recent analysis originates from evidence held within U.S. Department of Justice-associated Epstein Library archives (File No.: EFTA01104262). As with any such material, appearance within a network map does not, by itself, imply wrongdoing, and proper interpretation requires full contextual understanding.

What remains relevant is the broader, well-documented pattern of efforts by certain billionaire actors to influence and control scientific and academic ecosystems, which appropriately invites scrutiny of associated institutional relationships and enabling structures, including those connected to Arnold Ventures LLC.

ScienceGuardians™: Institutional Authority Rooted in the Academic Community

ScienceGuardians™ is operated by a dedicated team of highly skilled data and IT professionals who have undergone extensive training in academic publishing, ethics, and integrity. While not publishing authors themselves, these experts have been thoroughly educated in the full lifecycle of academic publication, including peer review, authorship standards, conflict of interest management, editorial workflows, and scientific misconduct prevention.

ScienceGuardians™ has developed the first Fully Verified Post-Publication Peer Review Platform, where academics can interact freely—without moderation or censorship and without fear of harassment or intimidation—available at https://t.co/kH0Diy6RwM.

In parallel, ScienceGuardians™ provides comprehensive ethical guidelines, training resources, and educational infrastructure designed to empower the academic community and eradicate misconduct through structural reform and awareness, available at https://t.co/dhsdLhuHya.

ScienceGuardians™ is entirely self-sustained. It receives no corporate sponsorship and accepts no cash donations. Its operations are supported through the voluntary contributions of senior scientists, legal advisors, and ethics and integrity experts who have chosen to waive their professional fees in support of restoring fairness, accountability, and integrity to the academic ecosystem.

Final Professional Courtesy Notice

This announcement is issued as a final professional courtesy to all actors whose financial resources, institutional infrastructure, or operational support may have enabled systemic harm within the academic ecosystem.

We are fully aware of the identities of the PubPeer “PubSmear” Network Mob, their enablers, and their promoters across multiple jurisdictions worldwide. These include actors embedded within compromised editorial structures, affiliated media channels, research integrity offices within academic publishing organizations, and complicit or compromised academic actors operating within institutional environments.

We have documented these operational structures, identified enabling mechanisms, and securely archived extensive evidence concerning coordinated activities, systemic exploitation, and reputational manipulation.

Transparency and corrective action remain the responsible path forward.

ScienceGuardians™ remains committed to restoring integrity, protecting researchers, and eliminating the systemic plagues corrupting academia.

The academic community is no longer structurally defenseless.

The era of unchecked exploitation is ending.

ScienceGuardians™
The First Fully Verified Post-Publication Review Platform

🔱 Empowering Researchers. Restoring Integrity. Eliminating the Plagues Corrupting Academia. 🔱

[Kalon @Kalonshaka]

@SciGuardians Clear, precise…awesome post with important information that most of public is completely unaware of! 👏

[Yellow Jacket @YellowJ97022132]

@johnarnold @SciGuardians No , the MAP is provided by https://t.co/mWt9uEePs0 🤫
https://t.co/xqKVEPKCui

And https://t.co/bPpnU21GVM spoke about your generosity
https://t.co/EMNKLCR9iG 🤔

[sabine hazan md @SabinehazanMD]

@BillAckman
Papers in the medical literature are being retracted at an alarming rate. The Arnold Foundation has funded and supported platforms like PubPeer, which have played a central role in driving those retractions.
An innocent person deserves the right to face their accuser directly. Instead, the response has been systematic censorship of anyone whose work threatens powerful financial interests—interests explicitly tied to figures like @BillAckman and his portfolio.
I ask you plainly: Why did the Arnold Foundation sponsor PubPeer to retract a scientific hypothesis on ivermectin (IVM)? And why is an organization connected to the now-discredited, fraudulent uBiome venture now leading attacks against @weldeiry?
If you genuinely stand for innocence and transparency, then speak. Because right now, the widespread perception—mine and that of many others—is that the Arnolds are far from innocent in these matters. When science itself is interfered with, it harms every one of us. Even within your own circles, people are quietly questioning the Arnolds’ role.
@SciGuardians may have pushed their investigations too far—or they may be hitting the exact target. Either way, the moment papers are retracted, courageous physicians are smeared, and honest scientists are attacked, a line was crossed and conflict began.
We can keep waging this war of mutual destruction, or we can choose to sit down at the table and talk. The decision is yours, @johnarnold.
I see patterns that go far beyond the surface. The way certain attacks involving Epstein are being weaponized appears designed to reflect on an entire religion. Nothing here is coincidental. As human beings under God, we are called to seek the path of righteousness.
True righteousness does not involve destroying the reputations of dedicated scientists and physicians who have devoted their lives to a discipline that is, by its very nature, provisional and evolving. In science, very little is ever permanently “true” or “false”—it is always subject to new evidence. What matters is that it advances. Smearing those who follow where the evidence leads is not defense of science; it is its betrayal.
Let us choose dialogue over destruction. The choice is ours.