Jeong Woon Lee

PhD student and a veterinarian @SNUnow studying the interface of cancer and immunity. ATAC-seq and organoid enthusiast. Loves pet dogs!

[Keun Hong Son (keun-hong.bsky.social) @new__hong]

My first PhD project in @je_yoel lab @SNUnow is finally out @biorxivpreprint
Work with my science partners @PrecursorCell & @MethylAReum
We present EpiC Dog - our initiative to map the dog epigenome and generate a reference functional annotation.

[Mark Borris Aldonza (@precursorcell.bsky.social🦋) @PrecursorCell]

And oh! To give faces to the co-first-authors and our PI 🧑‍🔬👩‍🔬🔬🧬, here's an impromptu photo taken on our lab balcony (forget my hair pls😥) @new__hong @MethylAReum @je_yoel Also want to acknowledge co-authors @ATACseek twitterless Kang-Hoon Lee, Kyung-Ju Shin & Keunsoo Kang. /14

[Mark Borris Aldonza (@precursorcell.bsky.social🦋) @PrecursorCell]

Our many-years-in-the-making EpiC Dog epigenome paper is finally out as preprint @biorxivpreprint
Close collaboration with our lab's lead bioinformatician @new__hong & MBD-seq aficionado @MethylAReum, spearheaded by our versatile PI @je_yoel @SNUnow #Epigenome #Genomics #Dog A🧵

[glycopreprint @glycopreprint]

Widespread multi-targeted therapy resistance via drug-induced secretome fucosylation https://t.co/ajuBKy7V2k #glycotime

[bioRxiv @biorxivpreprint]

Widespread multi-targeted therapy resistance via drug-induced secretome fucosylation https://t.co/zuEcavJ6ya #bioRxiv

[Mark Borris Aldonza (@precursorcell.bsky.social🦋) @PrecursorCell]

Inaugural @biorxivpreprint from our lab! This has been an exciting journey to identify core fucosylation as a widespread modification of therapy-induced cancer secretomes with Profs. Yoosik Kim, Je-Yoel Cho, Pilnam Kim & others esp. Dr. Junghwa & Insung. Our first #glycotime! 1🧵

[@[email protected] @David_McGaughey]

Pleased to see that @KasperDHansen and co’s tricycle (https://t.co/xfBDmz55hK) is indeed as fast as they claim. Runs in minutes with ~775k cells. The “CCStage” tool has *many* NA’s # with my data

[Mark Borris Aldonza (@precursorcell.bsky.social🦋) @PrecursorCell]

That wraps up our story on AXL bypass driving tolerance to EGFR-TKIs after chemo failure. Please also check out our earlier work @ScienceAdvances https://t.co/0Ztw8tsTKg

[Mark Borris Aldonza (@precursorcell.bsky.social🦋) @PrecursorCell]

Here's the link to our @SciReports article https://t.co/2BrP9UxrOQ

[Mark Borris Aldonza (@precursorcell.bsky.social🦋) @PrecursorCell]

Why do some targeted Rx fail in second-line setting after chemo? In our latest story out now @SciReports we present a mechanism driving profuse cross-resistance to EGFR inhibitors after chemo failure in multiple cancers. An update project to our first story @ScienceAdvances. 🧑‍🔬👩‍🔬

[Jeong Woon Lee @ATACseek]

I want to apply as a post-doc!!!

[Mark Borris Aldonza (@precursorcell.bsky.social🦋) @PrecursorCell]

Future members of my lab when I become a PI...

[Kelsey Fisher-Wellman, PhD @KFW_Lab]

Last week in mitochondrial bioenergetics and #Cancer brought to you by @BiomedNew https://t.co/mvAIMDdxBu. Lab pick of the week from @NatureCancer detailing potential therapeutic options for a mitochondrial subtype in GBM. https://t.co/bzsXFac1vE

[Mark Borris Aldonza (@precursorcell.bsky.social🦋) @PrecursorCell]

This is a full-blown service to all sc-omics trainees!

[Jeong Woon Lee @ATACseek]

Excited to play around with our precious mammary organoids! Prepping lots of stocks for CRISPR screen!!

[Mark Borris Aldonza (@precursorcell.bsky.social🦋) @PrecursorCell]

Absolutely thrilled to share that our lab @SNUnow has officially jumped on the #organoid challenge and reached a new milestone by generating canine mammary tumor-derived organoids! A true team effort w/ @ATACseek. Excited to do HT screening, imaging, and omics w/ @new__hong.

[Eytan Ruppin, MD, PhD @EytanRuppin]

Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities https://t.co/DXkGzdqVaT

[Jeong Woon Lee @ATACseek]

Interesting work on collateral drug resistance im cancer led by my labmate @PrecursorCell

[Mark Borris Aldonza (@precursorcell.bsky.social🦋) @PrecursorCell]

Hot off the press! Our recent work uncovering pretty interesting mechanisms that account for resistance evolution between taxol and EGFR-TKIs is now out @ScienceAdvances (1/n)

https://t.co/0Ztw8tKuBO