Hanjun Lee

PhD candidate, Elledge Lab, Harvard Medical School
SB in Biology, MIT

[Hanjun Lee @Hanjun_Lee_]

In our new paper in @NatureComms, we demonstrate RB’s role in regulating chromosome conformation independent of cell cycle control. Loss of RB prevented mitotic removal of cohesin, leading to topological insulation and reduced enhancer-promoter interaction
https://t.co/1weWbD76Up

[Mass General Brigham Research @MGBResearchNews]

In a new study, researchers from @MassGenBrigham and colleagues found that loss of RB protein disrupts DNA organization and gene control.

Read more, published in @NatureComms: https://t.co/GK2B3nuHWP https://t.co/KKjhHF2lVo @gsanid
@Hanjun_Lee_ @IGkotinakou

[Ioannis Sanidas @gsanid]

Excited to share the final version of the first paper from my lab, now in @NatureComms
We uncover a non-canonical role of RB in genome regulation, showing that RB is not just a cell cycle regulator but also a key organizer of 3D chromatin.

https://t.co/y01tUUj8vg

🧵👇

[Hanjun Lee @Hanjun_Lee_]

@chendi_li @NatureComms Thank you so much, Chendi! 🙌

[Hanjun Lee @Hanjun_Lee_]

In our new paper in @NatureComms, we demonstrate RB’s role in regulating chromosome conformation independent of cell cycle control. Loss of RB prevented mitotic removal of cohesin, leading to topological insulation and reduced enhancer-promoter interaction
https://t.co/1weWbD76Up

[Ioannis Sanidas @gsanid]

It was a privilege to work with @Hanjun_Lee_ , @IGkotinakou, and the team on this exciting study, which reveals a new non-canonical role for RB as a transcriptional activator through the regulation of chromatin insulation and enhancer-promoter interactions.

[Hideko Isozaki @HidekoIsozaki]

I'm pleased to announce I started my laboratory as a Professor at Kanazawa University Cancer Research Institute in Japan! My laboratory studies how cancers evolve and progress, especially focusing on innate immunity and genomic instability. We'er hiring an Assistant Professor!

[Karuna Ganesh @KarunaMDPhD]

Thrilled to share our paper now out @Nature delineating #plasticity during #CRC #metastasis, a fantastic collaboration led by @andrewrmoorman @elliebenitez11, and @f_cambuli from the @KarunaGaneshLab and @dana_per lab! https://t.co/NYQRHfq3gz
https://t.co/Z4GFwqL8G2. A 🧵

[Rodrigo Romero Rangel @RRomero_PhD]

🚨🚨Now online @NatureCancer, my postdoc work in @SawyersLabMSKCC with @dana_peer 🚨🚨 we establish a powerful organoid transplantation model of prostate cancer neuroendocrine transformation. Open access for all! @HHMINEWS
https://t.co/FJc0WSBvDQ
A 🧵... /1

[Science Magazine @ScienceMagazine]

The central dogma of molecular biology states that genetic information flows from DNA and RNA to protein, with reverse transcription converting RNA to DNA.

In the pursuit of understanding how bacteria defend themselves from viral infection, two groups have found alternative pathways to making genes from RNA that did not previously encode proteins. Learn more this week in Science: https://t.co/MT1Bhru2Ox

[Hanjun Lee @Hanjun_Lee_]

@yan_pengze @LabPolyak Congrats, Pengze 🎉

[Cees Dekker @cees_dekker]

But here's a new twist!

Today, we put a new #CDlab paper on @biorxivpreprint where we developed a new tweezer assay to directly measure how much supercoiling twist is induced into the extruded loop by an individual SMC in each loop-extrusion step!

https://t.co/nXwCEVKflF

1/

[Chowdhury Lab @ChowdhuryLab]

Out in @Nature today! We report that a CDK5-cyclin B1 complex maintains proper cell division. We discovered that CDK5, a long regarded non-cell cycle CDK functioning only in neurons, yet overexpressed in many cancers, does regulate mitosis! 

Link: https://t.co/ovFZyOXVAM

[Hanjun Lee @Hanjun_Lee_]

@melodyDiBona @JunLi_916 @Samuel_Bakhoum @SteSantaguida @ScienceMagazine Congratulations, Melody! 🎉

[IMBA imbavienna.bsky.social @IMBA_Vienna]

Open2C, an international team of bioinformaticians including the group of Anton Goloborodko at IMBA, recently published three new open-source software tools for data analysis in 3D chromosome biology and genomics.
More about Open2C here: https://t.co/gBpB9pfvDI

[Thomas R. Cox @thomasrcox]

The phrase ‘metastasis accounts for 90% of cancer deaths’ is one of the most widely used in cancer research, yet it is overly simplistic, imprecise, and it is difficult to find any primary analysis supporting the statement. | → https://t.co/kiv5NQsUZL ← | 🧵(1/5)

[MIT Biology @MITBiology]

Hanjun Lee, SB '24, planned to pursue chemistry at MIT. A course in genetics changed that. “I don’t think I’m a great scientist, yet, but I now have some sense of how to become one." @HanjunLee_MIT
https://t.co/utfxcc7fUT

[Mitch Guttman @mitchguttman]

What are the functional roles of 3D genome organization? Our paper in @Nature led by @_prashantbhat demonstrates how dynamic 3D genome organization around nuclear speckles plays a crucial role in regulating mRNA splicing efficiency. https://t.co/8KwfJHQWTt

[Cell @CellCellPress]

In the latest issue! From periphery to center stage: 50 years of advancements in innate immunity https://t.co/roX7NHZPZX

[KaelinLab @kaelin_lab]

Check out the group's latest "Up-Assay"!
https://t.co/bf0hiVF4jX