Arno Téblick MD PhD

Father & husband. Resident Nephrology. Doctoral thesis on the “impact of steroid treatment during sepsis/critical illness”

[Arno Téblick MD PhD @ATeblick]

Recent findings question the scientific basis for broad implementation of stress dose #hydrocortisone in #sepsis

Now out in Endocrine Reviews!

@TheEndoSociety
@EndoSocJournals

@LicMlab

HPA-response to Critical Illness: A Concept in Need of Revision https://t.co/jJHIUWnp1p

[NEJM @NEJM]

TGC-Fast: In this randomized, controlled trial involving critically ill patients not receiving early parenteral nutrition, tight glucose control did not affect the length of time that ICU care was needed or mortality. Read the full trial results: https://t.co/mbv7fSja2h

[ICU lab - KU Leuven @LicMlab]

Hypothalamus-Pituitary-Adrenocortical response to critical illness: a concept in need of revision https://t.co/vcPpfyRQsc

[Arno Téblick MD PhD @ATeblick]

@nickmmark 2) any evidence on the absorption of oral fludro in the early phase of vasopressor-refractory shock? And 3) a dose of 40mg of HC already provides maximal mineralocorticoid activity. What is the proposed mechanism of adding (oral) fludro?

[Arno Téblick MD PhD @ATeblick]

@nickmmark 1) Mortality difference seems to be already set at day 1. In the group H+F the initiation of H was later as in group H … so isn’t the mortality difference just a reflection of timing of the drug rather than the drug choice itself?

[Arno Téblick MD PhD @ATeblick]

Check it out in open access for:

* the function (and dysfunction) of the #HPA axis during the various phases of critical illness 🧪🔬
* the presence (or not?🤔) of sepsis-induced glucocorticoid resistance (#CIRCI)
* the good and bad of high doses of #glucocorticoids 💉💊

[Arno Téblick MD PhD @ATeblick]

In the wake of my PhD graduation, my promotors (@LicMlab) and I wrote a contemporary review on 'the #hypothalamus-#pituitary-#adrenal axis in #sepsis' ; now published in @eBioMedicine !
1/

https://t.co/udxYnxpQbo

[Central European Journal of Urology @CEJUrol]

Case series of collecting duct #RCCs from @AZKlina published in current @CEJUrol by @WiesVdbruggen and Colleagues. Despite multidisciplinary treatment with surgery and TKIs, the prognosis of collecting duct RCCs remains poor.

[Portland Press @PPPublishing]

Are neuroendocrine responses to sepsis such as the acute fasting response harmful or beneficial? @ATeblick et al. emphasise the need for personalised medicine in new #ClinSci review https://t.co/sbAFEdbUrq

[Arno Téblick MD PhD @ATeblick]

@phlegmfighter @nickmmark A lot of opinion pieces/editorials/… have been adressing the possible differences between the studies (methodology etc.); for example https://t.co/39SPDy21qR . But more importantly: a new multicenter study (n>9000) is nearly finished and will come out soon: trial no: NCT03665207

[Arno Téblick MD PhD @ATeblick]

@phlegmfighter @nickmmark Van den Berghe fraudulent? Please explain…

[Arno Téblick MD PhD @ATeblick]

Last talk today at #ENDO2022 on GR expression and signaling during critical illness! @TheEndoSociety ! Check out our open access paper in @eBioMedicine for more details! #sepsis https://t.co/A3MwB4edTQ

[Arno Téblick MD PhD @ATeblick]

Today I presented our work on #steroids and #CIRCI in critically ill patients @ #ENDO2022 #ICU #sepsis. It was a true honor to be invited by @TheEndoSociety for this Symposium talk.

[eBioMedicine – The Lancet Discovery Science @eBioMedicine]

1/ Impact of duration of critical illness and level of systemic glucocorticoid availability on tissue-specific glucocorticoid receptor expression and actions https://t.co/7AJPyTkgkE

[Arno Téblick MD PhD @ATeblick]

More information? => our paper is available in open access format in @eBioMedicine #sepsis https://t.co/FTxceBfex2 8/8

[Arno Téblick MD PhD @ATeblick]

Our latest paper is out! @LicMlab

Wondering about "glucocorticoid resistance" during #sepsis?
Treating patients in the #ICU with #glucocorticoids?

Open access in @eBioMedicine !

https://t.co/FTxceBfex2

👇1/n

[Arno Téblick MD PhD @ATeblick]

These findings argue against maladaptive generalised glucocorticoid-resistance necessitating #glucocorticoid treatment ❌💊💉. 7/n