Abolfazl Nik-Akhtar

A mixture of Cachexia and Placental dysfunction - Researcher
@PlacentaLab

[Cell Metabolism @Cell_Metabolism]

New! Online now: Insulin resistance and type 2 diabetes as allostatic responses to chronic nutrient excess https://t.co/nl8ass4FLr

[Kevin Goeij @KevinGoeij]

A major work from our lab is out in Science! @ScienceMag, another key step towards a true demonstration of RNA self-replication. https://t.co/2Fe8XonYst (1/6)

[Carolina Tropini, PhD @CTropini]

CIHR funding rate: 13.6%.
Early 2000s: 30%+.

Canada’s new $1.7B Impact+ program recruits talent — but without increased Tri-Council base funding, we risk further strain on an already stretched system.

We’re calling for $1B over 5 years.
Support here: https://t.co/iknRwlOqvM

[Abolfazl Nik-Akhtar @A_NikAkhtar]

Imagine slicing a c57 placenta, sequencing each section, and compute it 3D, a living gene-expression map! Imagine doing it every 18.5 days of gestation: a placenta database website!
A full transcriptional atlas of the organ.
Who wants to run this together?@IFPA_Official

[Abolfazl Nik-Akhtar @A_NikAkhtar]

Read the paper at

https://t.co/6E4CnSHWW0

[Abolfazl Nik-Akhtar @A_NikAkhtar]

Congrats to @ycariacos & team on uncovering ferroptosis as a key driver of placental dysfunction in inflammation-driven preeclampsia.

[Abolfazl Nik-Akhtar @A_NikAkhtar]

Our study supported by advanced transcriptomics, demonstrated for the first time it’s specific to the inflammatory subtype—guiding personalized medicine and targeted therapies for each subclass of pre-eclampsia. Grateful to @PlacentaLab & thanks to @IFPA_Official!

[Ali Nik-Akhtar @nikakhtar_ali]

The road toward AAV-mediated gene therapy of Duchenne muscular dystrophy

👉 10.1016/j.ymthe.2025.03.065

@TasfaoutH

#DuchenneMuscularDystrophy #AAVVectors #MicroDystrophin #MiniDystrophin #CRISPR #GeneEditing #MuscleGeneTherapy #SystemicDelivery #DystroBlog #Nikilab.net

[Daniel J Drucker @DanielJDrucker]

In mice cysteine-restriction-induced adipose browning and #weightloss requires sympathetic nervous system-derived noradrenaline signalling via β3-adrenergic-receptors that is independent of FGF21 and UCP1 @NatMetabolism
https://t.co/bhwgTzow4J

[Eric Topol @EricTopol]

What's the meaning of the glucose spikes after eating?
A new @NatureMedicine study finds people have different food triggers and some connect with insulin resistance, along with ways to mitigate spikes
https://t.co/MIcS5hS5nU

[Martin Picard @MitoPsychoBio]

Beautiful animation of metabolic flux in the mitochondrial Kreb (TCA) cycle

The three "CO2" coming off the cycle is how you lose weight: carbon from your material body coming off as gas you end up breathing out

By @janetiwasa

[Ali Nik-Akhtar @nikakhtar_ali]

Exon skipping for Duchenne muscular dystrophy: a systematic review and metaanalysis

👉 https://t.co/RBSz37jEiI

#ExonSkipping #DuchenneMuscularDystrophy #DMD #Eteplirsen #Drisapersen #ClinicalTrials #6MinuteWalkTest #MetaAnalysis #AntisenseOligonucleotides

[Abolfazl Nik-Akhtar @A_NikAkhtar]

While making Ghorme Sabzi, an Iranian dish, I started thinking about the first person who ever cooked food. Were they a chemist experimenting with ingredients? Isn’t cooking like running a delicious science experiment in a reactor pot!”

[Abolfazl Nik-Akhtar @A_NikAkhtar]

What do all maladies have in common?

Increased entropy!

Isn’t it amazing how the body evolved to restore its low order?

[Abolfazl Nik-Akhtar @A_NikAkhtar]

@TahaAzad2 @chembioBryan @Tai_ImmunoLab @QFKC @TommyAlain3 @Rezaeir75 @philippavalenci Congratulations on this remarkable achievement! The innovative use of antibiotics for selecting viruses could accelerate advancements in the field of OV. Excited to see its applications unfold. Outstanding work! @Rezaeir75

[Taha Azad Lab @TahaAzad2]

Happy to share our new paper in Nature Biomedical Engineering! Special congratulations to the first author, Dr. Reza Rezaei, and our amazing collaborators.
@Rezaeir75
@Tai_ImmunoLab
@TommyAlain3
https://t.co/JSyJdwLueb
https://t.co/tMYn6BExuT

[Abolfazl Nik-Akhtar @A_NikAkhtar]

Just like in “March of Progress” science moves forward step by step. Remember that future scientists will follow the path we leave behind.

[Oded Rechavi @OdedRechavi]

University websites are like distant stars, when you look at them you see the scientists as they used to be many years ago

[David R. Liu @davidrliu]

Today we report in @NatureBiotech a system for the laboratory evolution of engineered virus-like particles (eVLPs) that enables the discovery of eVLP variants with desired properties, including improved production and delivery potency. 1/13
PDF: https://t.co/OKvvoawP9n

[Abolfazl Nik-Akhtar @A_NikAkhtar]

Today, my positive control decided to take a day off, and all I could think of was Neil deGrasse Tyson’s wisdom: ‘The universe is under no obligation to make sense to you.’ Honestly, neither is my experiment apparently.