James Laboratory

Researching skeletal development, repair, and neoplasia @JohnsHopkins. BST Pathologist @JHUPath.

[Manyu ZHU @Manyu_z1]

Excited to share our recent paper in @ScienceTM ! We highlight tendon-associated sensory nerves are not only pain-transmitting fibers, but also protective regulators of tendinopathic changes through FGF1 signaling. Thanks @AaronWJames_Lab. Check it out : https://t.co/v9Q3PWzZyN

[James Laboratory @AaronWJames_Lab]

Congratulations to first author Dr. Manyu Zhu and team for their work in @ScienceTM 👏👏 Showing for the 1st time that sensory nerves protect against tendon degeneration! Work done @JohnsHopkins @JHUPath
https://t.co/oQ3ZSH5800

[Bone Research_Editorial Office @BoneRes_Office]

#Hemophilia patients lacking Factor VIII face hidden bone loss, not just bleeding. Replacing this clotting protein restores #bone density, expanding hemophilia care from stopping bleeds to protecting #skeletal health.😀
@BoneRes_Office
https://t.co/wjcIHBjlrA

[Bone Research_Editorial Office @BoneRes_Office]

Unwanted #bone growth in soft tissues after #trauma is driven by a protein switch called #PRMT6 that amplifies #inflammation. Targeting it early could prevent this disabling condition while preserving normal tissue repair, offering a precision therapy for injury patients.👇
@BoneRes_Office
https://t.co/zKq6E2SYjp

[Bone Research_Editorial Office @BoneRes_Office]

The #spine contains a newly discovered network of lymphatic #vessels that drain brain fluid and control #inflammation. Rewriting long-held anatomy beliefs, this hidden pathway could unlock targeted therapies for #spinal diseases, #nerve damage, and chronic back pain.🥳
@BoneRes_Office
https://t.co/LDISivzFwY

[James Laboratory @AaronWJames_Lab]

Congrats to Zhao Li and team for their work out today. 👏 👏 Hedgehog signaling implicated in nerve-directed calvarial bone healing! See results here. Work performed at @JohnsHopkins @JHUPath ⬇️ ⬇️ ⬇️
https://t.co/rU6CmeQeQH

[Bone Research_Editorial Office @BoneRes_Office]

After menopause, bone-breaking cells become overactive because they get coated with sugar molecules. Stripping off this sugar could stop bone loss as effectively as estrogen but without hormone therapy's risks.👇
#menopause #bone #hormone
@BoneRes_Office
https://t.co/GkgsxqlGWN

[Bone Research_Editorial Office @BoneRes_Office]

Long-term steroid use destroys hip joints by blocking blood flow and killing bone tissue. Understanding these cellular mechanisms offers targets for early intervention and prevention, potentially sparing patients from debilitating joint collapse and replacement surgery.😀
#steroid #bone #joint
@BoneRes_Office
https://t.co/G608MuFF8P

[Bone Research_Editorial Office @BoneRes_Office]

Bone cells sense how stiff their surroundings are through their microtubule skeleton, directing cell division. This reveals how physical forces guide cartilage repair, pointing to new treatments for joint injuries and osteoarthritis.🧐
#bone #osteoarthritis
@BoneRes_Office
https://t.co/a4vFRbUxeI

[James Laboratory @AaronWJames_Lab]

Love this. As the year progresses we are looking for new and talented trainees! Happy to meet potential lab members interested in skeletal neuroscience @ORSsociety meeting #ORS2026

[Sowmya Ramesh @sowmya_rames]

Quiet motivation, pushing you forward into the year ahead.

Happy New Year from the James laboratory @AaronWJames_Lab ✨

#Science #Research #AcademicLife #HappyNewYear2026

[Sowmya Ramesh @sowmya_rames]

Quiet motivation, pushing you forward into the year ahead.

Happy New Year from the James laboratory @AaronWJames_Lab ✨

#Science #Research #AcademicLife #HappyNewYear2026

[James Laboratory @AaronWJames_Lab]

@HopkinsMedNews @PNASNews @HopkinsMedicine @JHUPath @US_FDA @sowmya_rames @Qin_Qizhi Grateful to have our work highlighted by @HopkinsMedNews. As this story continues to grow, we are looking for new and talented trainees. Happy to meet potential lab members @ORSsociety meeting #ORS2026

[Bone Research_Editorial Office @BoneRes_Office]

A bone-strengthening hormone (PTH) relieves chronic back pain by reversing spinal bone thickening and blocking painful nerve growth. This suggests repurposing an existing osteoporosis drug to treat age-related spine degeneration in humans.🧐
#PTH #bone #osteoporosis
@BoneRes_Office
https://t.co/SJPgxg2C27

[Bone Research_Editorial Office @BoneRes_Office]

Lymphatic vessels in bones and joints drive arthritis and fracture progression. Targeting lymphatic vessels could speed healing and reduce inflammation—offering new drug targets for common musculoskeletal disorders.🥳
#musculoskeletal #bone
@BoneRes_Office
https://t.co/CqRz0pY3UV

[Denis Wirtz @deniswirtz]

Source for this data: NIH!

[Bone Research_Editorial Office @BoneRes_Office]

Nerve signals help heal bones by calming inflammation. Spicy food or a pain-relief cream boosts this process, offering new ways to treat bone diseases.👍
#bone #nerve
@BoneRes_Office
https://t.co/jwc785dTm6

[Denis Wirtz @deniswirtz]

NIH is not issuing awards. You may think that it's because they it is coming up with new directions of research...The apposite is true.

Here is a graph showing how many fewer new funding opportunities that NIH has posted over time.

-91%, a trend that started on Jan 2025.

[James Laboratory @AaronWJames_Lab]

It's that time of year! Hiring in the James lab. Please join this stellar group to lead our next effort! Most recent pub here 🔽🔽🔽👇👇👇 https://t.co/UoFvo0ueHE
Work @JHUPath @HopkinsMedicine @JohnsHopkins

[Hao Yin @HaoYin20]

#FGF9 Adhesive Capsulitis
cytoHubba➡️FGF9 as an AC hub gene

FGF9 ⬆️in 👤AC glenohumeral joint capsule & 🐭Shoulder Stiffness (joint immobilization)
Which cell type?🧐
Where is FGF9 Ab info?😳

FGF9 ⏫NIH3T3 fibroblast proliferation migration & α-SMA level in a PI3K-dependent manner

@FrontCellDevBio 2025
https://t.co/D0eaAMXIts

[Manyu ZHU @Manyu_z1]

Our paper published in Science! Big congrats to @AaronWJames_Lab 🎉!Check it out: https://t.co/TK4sRBbjGi.