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Scientists Develop DNA Nanorobot That Targets Cancer Cells
A team of researchers at Karolinska Institutet has created a tiny DNA-based nanorobot designed to attack cancer cells while minimizing harm to healthy tissue.
One of the major difficulties in cancer treatment is that many therapies cannot distinguish perfectly between cancerous and healthy cells, often leading to unwanted side effects. The newly developed nanorobot aims to address this challenge by remaining inactive as it travels through the body.
Built using a technique similar to DNA origami, the microscopic structure stays folded shut under normal conditions. It is engineered to respond to the more acidic environment often found around certain tumors. When it detects these conditions, the nanorobot unfolds and releases molecules that activate Tumor Necrosis Factor (TNF) receptors sometimes referred to as “death receptors.”
These receptors can trigger apoptosis, the body’s natural process of programmed cell death. Although scientists have long explored using these receptors in cancer therapy, a major obstacle has been avoiding damage to healthy cells that also carry them. The nanorobot’s pH-sensitive design provides a potential way to deliver the treatment more selectively.
In experiments involving mice with breast cancer, researchers reported a reduction in tumor growth of approximately 70%.
The technology remains in the early stages of development and has not yet been tested in humans. Future research will focus on evaluating safety, testing the approach in more advanced cancer models, and exploring whether the nanorobots can be adapted to target additional types of cancer.
Source: IBSA Foundation – “Nanorobot to target cancer cells and spare healthy ones.”