Adam Bond

29 Wirral/London Senior Scientist at Kesmalea Therapeutics

[María Rodríguez-Ríos @MariaRRios3]

I am delighted to share the story that we've been crafting at the @UoDCeTPD in collaboration with @Tocris @biotechne for the last to years! We're thrilled to present BromoCatch - a self-labeling tag platform for protein analysis and manipulation.

https://t.co/gmZueymcuD

[J. Am. Chem. Soc. @J_A_C_S]

Leveraging DualLigase Recruitment to Enhance Protein Degradation via Heterotrivalent Proteolysis Targeting Chimera Journal of the American Chemical Society @oeaw @dundeeuni @alessiociulli @UoDCeTPD #DualLigase #Protein #Degradation #Heterotrivalent #PROTAC https://t.co/KtOLYo1Qbc

[Alessio Ciulli @alessiociulli]

Happy to share that this work is now published in the Journal of the American Chemical Society @J_A_C_S https://t.co/ZJabEpAMps

[Yuki Hatoyama @yh_biol]

This study was conducted in collaboration with Alessio's group @alessiociulli and was co-authored with my colleague @MoutushiIslam1. I would like to express my gratitude to everyone involved in this study.

https://t.co/EUUvKmr7Kf

[Alessio Ciulli @alessiociulli]

Excited to share our latest work combining VHL and CRBN in a single trivalent PROTAC to boost protein degradation. Great #TPD collaboration with @georg_e_winter and Kristin Riching, led by @AdamBond_ Miquel & Celia in each lab @UoDCeTPD @CeMM_News @promega https://t.co/bogZzn4ic4

[Adam Bond @AdamBond_]

@ICR_London https://t.co/8SSkt1moQt

[Adam Bond @AdamBond_]

@alessiociulli @GossGroup @UoDCeTPD Well done Lexie!

[Alessio Ciulli @alessiociulli]

Very happy our work on improving VHL ligands is now out @ACSBioMed #jmedchem great teamwork with Michael Gutschow and co. at Bonn. We design a new di-Methyl analogue of VH101 (cmpnd 30) and qualify it as the most potent VHL inhibitor in vitro and in cell https://t.co/Exk6Lco6p6

[Adam Bond @AdamBond_]

I'm fundraising for The Institute of Cancer Research (ICR). Check out my @JustGiving page and please donate if you can. Thank you! #JustGiving https://t.co/LjUXQ06wEb

[Adam Bond @AdamBond_]

@alessiociulli @mrcppu @dundeeuni Congrats Alessio! Huge achievement!

[ChemRxiv Bio and Med Chem @chemRxivBiochem]

Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1alpha (HIF-1alpha) Stabilizers
https://t.co/PbwDZNCUSb
#chemrxiv_biochem

[Ollie Hsia @ollie_lh]

Here, in addition to describing a novel modality within the TPD field, namely an intramolecular glue degrader, we also shed light in an intrinsic BRD4-DCAF16 interaction. Perhaps this answers why BRD4 is such an easy target for PROTACs + glues! Thread below from. Great work all!

[Adam Bond @AdamBond_]

@ollie_lh Amazing work guys! Love it!

[Sky Sports News @SkySportsNews]

🗣 "First of all they tried to blame Liverpool supporters, and now they're trying to blame fake tickets."

Kaveh Solhekol questions the French Minister's response to the chaos at the Champions League final.

[The Redmen TV @TheRedmenTV]

I fucking love him so much. Today was a pick me up I needed, hopefully the players and staff too! 🔴💪🏻

[Alessio Ciulli @alessiociulli]

Excited to debut XL01126 – a first-in-class PROTAC degrader for the protein kinase LRRK2, a high-profile target in Parkinson’s disease. Great #CeTPD collaboration with Dario Alessi @mrcppu team and @RuiMoreira_UL Please share, thread below https://t.co/6hGoDP1XJH

[Tocris Bioscience @Tocris]

Available Now! EXCLUSIVE to Tocris, BromoTag® AGB1 is a potent, fast, and selective degrader for targeting Brd4BD2 L387A fusion proteins that can be used in cells and in vivo: https://t.co/fJlzVSLcUb

Developed by: @Alessiociulli, @AdamBond_ , Conner Craigon & @Dundeeuni.

[UoD Life Sciences @UoDLifeSciences]

Innovator of the Year
🌟 Winner of best early-stage business idea: Adam Bond & Connor Craigon (CeTPD) for a BromoTAG is a new ligand-inducible degron system.
Read about this work: https://t.co/bpZj1RP7Q8

[Adam Bond @AdamBond_]

@pwk2013 @ToriKleinPhD @alessiociulli In all cases the esters were as stable as their amide counterparts in plasma and remained active in our biological assays. We have not looked into taking away the carbonyl but that is something we could look into

[Adam Bond @AdamBond_]

Our amide-to-ester subsitution paper is finally out now in J Med Chem!
Big thank you to co-first author @ToriKleinPhD, to Conner Craigon and to @alessiociulli and Scott Lokey for helping to put together this cool story! https://t.co/lvY3jOKBt9
#TPD #medchem #PROTACs