Melanie Adams-Cioaba

BizDev, CryoEM, xtals, lab automation, xtals, genomes, cells & more! Thoughts & Tweets are my own.

[Structural Biology @ActaCrystD]

In 216 ligand-bound structures of human FABP isoforms, many at better than 1.2 Å resolution, an estimated 15% of the ligands had a different chemical composition to that expected  #StructureBasedDrugDesign #FattyAcidBindingProteins #LigandBinding https://t.co/CrmBwVZe9o

[Generate:Biomedicines @generate_biomed]

We’re scaling structure as a core capability in AI-native drug design.

#TeamGenerate is searching for an Executive Director of CryoEM to lead a multidisciplinary team operating within one of the most advanced high-throughput structural biology platforms in the world. Reporting to our Chief Technology Officer, you’ll set the vision and deliver on the execution—expanding what’s possible in structural throughput and data quality. You’ll partner closely with machine learning, automation, and protein science teams to embed #cryoEM into a true design–build–test–learn loop.

This is an opportunity to shape a capability that will transform structural biology from a bottleneck into a high-speed engine for discovery—redefining how medicines are conceived, designed, and developed.

If this sounds like your next challenge, let’s talk.
https://t.co/yRjJl2oqam

[Structure @Structure_CP]

High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1 https://t.co/8il5gKdnvl

[Structural Biology @ActaCrystD]

Four case studies are presented in which rationally designed surface modifications were key to establishing crystallization conditions for the target proteins @ActaCrystD @IUCr #SurfaceModification #SurfaceEntropyReduction #CrystalPacking https://t.co/xbQqQY2Dgz

[Yong Xiong Lab @Xiongosome]

Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells!

https://t.co/ScWOAQRjTw

[Membrane Protein PDB @MemProtPDB]

Structural characterization of two full length γδTCR/CD3 complexes | bioRxiv

https://t.co/lzaesBkizq

[Chiara Rapisarda @chiara_rapi]

New paper out in bioarxiv!. In collaboration with the team of Maks Ovsjanikov, Vincent Mallet developed an algorithm that is available as a plug-in for @UCSFChimeraX to find antibodies and nanobodies, within seconds, in #cryoem densities. https://t.co/7wR2FIjxdN. Try it out!

[David Taylor @davidwtaylorjr]

Check out our new work by fabulous grad student Rodrigo @TexasScience @ut_mbs! Guide RNA folds into gnarly geometry to tether tiny protein domains together. Fun collaboration with @metagenomi! DNA targeting by compact Cas9d and its resurrected ancestor https://t.co/1g0xsWZag7

[Han Kim @Kim_Hanseong]

Update on our kinase domain side project (37 kDa with a ligand): Previous sample had severe preferred orientation issues, pausing the project. Now back at it with new 2D classification results. Still preferred orientation persists, but we're optimistic about getting a map. #TGIF

[Melanie Adams-Cioaba @AdamsCioaba]

@Kim_Hanseong Very exciting to be back in Korea with such a fantastic group of companies to discuss #CryoEM in #drugdiscovery

[Membrane Protein PDB @MemProtPDB]

Time-resolved cryo-EM of G-protein activation by a GPCR | Nature

https://t.co/C6npFdn64O

[Dhruv Chauhan @Dhruvchauhan241]

This fantastic story is out on structural analysis of NLRP3 inflammasome activation. Happy to be part of it! Please check it out!

https://t.co/Oke4KQsJXi

[Moritz Hunkeler @moritzhunkeler]

Didn't think I would ever post ApoF, but here we go. First couple hours of test data collection on our new Tundra. How easy was that! And the best part: it's not hidden in a basement, but on the 3rd floor, one flight of stairs away from the office :D

[Melanie Adams-Cioaba @AdamsCioaba]

#Cryoem #ai #drugdiscovery

[Generate:Biomedicines @generate_biomed]

Kicking off the year with key clinical updates: first patient dosed with GB-0895 for mild-to-moderate asthma and advancement in our GB-0669 study for SARS-CoV-2. We’ve also expanded our relationship with @Amgen to push the boundaries of drug development. https://t.co/T5ALVgGGeW

[Murphy Lab @_Murphy_Lab]

Excited to share our preprint: “Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase” in which we obtained a structure of a 46-kDa membrane protein to 2.2 Å resolution without fiducials.
https://t.co/Cu2RxdxyZq

[Wim Hagen @WimJHH]

My indispensable right hand Natalya Dudkina is hiring, join our exciting R&D group at Thermo Fisher Scientific as Application Engineer, Cryo-EM.

RT please!

https://t.co/N60h1RJ7CM

[Madhumati (Madhu) Sevvana @msevvana]

Our structure biology and protein design team embedded within the vibrant scientific environment of Large Molecules Research at Sanofi in Cambridge Crossing, MA has an exciting postdoc opportunity to accelerate the development of next generation biologics.

#postdocjobs #postdoc

[Baobab AiBIO @BaobabAiBIO]

Please check our posters at #IMC20 today (9/13, Wed.) : Cryo-EM structure determination of sub-50-kDa protein : a case study on maltose binding protein - Kunwoong Park (LS 05.P, #2087).
See you at the poster session.

[Han Kim @Kim_Hanseong]

As promised, I've got our #IMC20 poster ready to go! If you're at the conference, swing by and say hi.
Got questions? Feel free to ask!

[Melanie Adams-Cioaba @AdamsCioaba]

“This is really about re-imagining structural biology at scale,” Grigoryan said. “What could we do if it was just as easy to get the structure of a protein you’re working with as sequencing a piece of DNA?” #cryoEM #drugdiscovery #biotech

[Ryan Cross the Science Boss @RLCscienceboss]

#AI is only as good as the data behind it, so de novo protein design startup @generate_biomed opened a lab with 4 #cryoEM microscopes to capture how well its AI-generated antibodies work to feed the data to its algorithms. My exclusive story for @endpts

https://t.co/Ph6tiHrwsu