Out today @cellhostmicrobe: An expanded arsenal of bacterial immune systems
Even if you previously read the preprint, don’t miss a major new result on the bacterial SEFIR domain, a homolog of human immune domains
A thread 🧵 1/9
https://t.co/nttSQhKWie
The (Yoav) Voichek lab has opened its gates at the Weizmann Institute, and is actively recruiting students and researchers at all levels - come explore gene regulation and computational genomics in a fun, friendly sprouting lab 🤗🥼⚗️🧪
https://t.co/GkH3LCKRck
Happy to share that I’m opening my lab at the Weizmann Institute of Science!
We’ll study systems-level regulation of bacterial defense, driven by RNA-protein interactions shaping cell fate.
Now recruiting PhD students & postdocs
https://t.co/HZ28Ns0y0C
Please reach out and share!
RNA-guided systems span kingdoms, from bacterial immunity to eukaryotic gene regulation. How did they evolve? We traced the origins of CRISPR-Cas13 and identified its likely ancestor: an RNA-based toxin-antitoxin (TA) system. Here’s what we uncovered:
https://t.co/oTGjiN2V3H
1/8
Very happy our paper on CARD domains in gasdermin anti-phage defense systems is now published in @Nature 🥳 Thanks to all the people involved especially the Kranzusch lab and @SorekLab
https://t.co/ZnFeX8zPpY
Fancy a postdoc in Munich? For a collaborative project between @SorekLab and @hornung_lab on antiviral innate immunity, we are looking for exceptional candidates with skills in immunology / biochemistry / computational biology. More details here:
https://t.co/VXPNk8Wi3R
Join us in Paris on April 8th-10th for the 2025 Symposium on the Immune System of Bacteria 🥖🍷🦠🧬.
Excited to welcome these amazing speakers at @institutpasteur .
Registration will open beginning of November. Abstract deadline February 28. Stay tuned.
My lab is up and running and just needs enthusiastic phage biologists to populate it! Contact me or apply in the link if you are interested in a postdoc exploring plasmid-dependent phage biology in beautiful (and super affordable!) upstate New York🍎https://t.co/nYWsBgNih4 1/3
Our NAD-reconstitution story is finally published in @nature
https://t.co/R1Ffc2H2dW
Thank you to all co-authors, especially to @hadarsamra, @FrancoisRousset, Elena Loseva, @ErezTzvi, @AdiMillman, and everybody in the @SorekLab for their help and support.
Thrilled to announce the Rothschild Symposium on phage-bacteria interactions in honor of @SorekLab! Join us for inspiring talks by @AudeBer, @ARDavidson_UofT, @AvigdorEldar, and @BejaLab. Plus, we're awarding 3 PhD prizes for exceptional research in the field. Don't miss it!🤩
Thrilled to share the final version of my postdoc project, out today in @Nature!
We investigated the Bil system – a ubiquitin-like antiphage defense system – and discovered a new defense mechanism!
More info in the thread below 👇
https://t.co/YSWMDKWHBq
It has recently been described that bacteria and eukaryotes share some part of their immune systems. But what do they share exactly? How did this evolve?
We propose the concept of ancestral immunity to explore this emerging topic.
Some answers but mostly questions 🙃.
ATTENTION! We are hosting an ML/AI workshop for college students and will sponsor the travel of three out of state participants and support up to 80 online. APPLY NOW if you’re interested. We have very special guests from AlphaFold (surprise). Please RT! https://t.co/h55cMaq9MD
Bacteria produce chemical compounds that humans harness as drugs (ex antibiotic).
We hypothesize that a major biological role of these compounds have been overlooked: antiviral defense.
👇Discovery of lantiphages, a large BGC family wt antiphage function
https://t.co/G1jeujZXQh
New preprint alert!🚀
Excited to share our latest preprint, where we discover a vast arsenal of phage anti-defense proteins using an interpretable machine-learning approach. Big thanks to @MartinPolz, @ShaulPollak, Mariusz Ferenc, and all collaborators!
https://t.co/jqw0Z0EiDL