https://t.co/8MeQuJeabH
π¨ Where does #lipid peroxidation kick off in #ferroptosis?π₯Excited to reveal #ER-#mitochondria#contactsites as ignition point of the lipid peroxidation cascade!
Huge kudos to our @SassanoLivia &our amazing collaborators making this breakthrough possible
It is time to leave! Together with a growing number of people and colleagues, we will no longer post or use our X account. You can find us here: @agostinislab.bsky.social. Hope to see you there soon!π
π₯³ Happy to share our new preprint where we describe the molecular machinery regulating iron transport between lysosomes and mitochondria, how it controls the melanoma drug tolerant persister state and the consequences of its perturbation on ferroptosis
π https://t.co/rEJy1jqorg
Absolutely! @CSHANews#Ferroptosis meeting was a huge success! We had a wonderful time in the beautiful Suzhou and discussed exciting science. Thanks to the organisers and to all participants for making this a memorable event! πππ
We show that melanoma cell-derived ApoE reshapes lipid architecture and enhances the antioxidant system of the drug-tolerant melanoma cells shielding them from ferroptosis. 2/3