Sebastian Akle

[Christopher Zou @chriswzou]

(3/4 releases) Today we share RareDiseaseBench, a series of 35 diagnostic workups reconstructed from published rare disease cases. In each task, an agent starts with a patient’s presentation, decides which tests to request and why, analyzes the data it receives, and uses the results to propose a diagnosis and management plan over one or more visits. Gemini 4 Argon does the best on this benchmark (43.8% attempt pass rate), with Opus 5.5 and Astra following.

Paper: https://t.co/ypZ5PdENXS
Results: https://t.co/0IZEml9BUB

More details in thread:

[owl @owl_posting]

The ballad of TIGIT

https://t.co/CWJbOLatwG

in 2014, an extremely promising class of oncology drug was identified. over the following decade, pharma spent $3B testing it on nearly 49,000 cancer patients. today, the drug category has been largely abandoned

this is its story

[Sebastian Akle @AkleSebastian]

@adamauton Hi Adam. Very interested! The StatGen link seems to be broken

[Basil🧡 (they/them) @LinkofSunshine]

Lmao the amount of SPY calls increased by over 10x literally 10 min before the announcement

[Sebastian Akle @AkleSebastian]

@dr_srishtin Miss watching tv together

[Spencer Greenberg 🔍 @SpencrGreenberg]

Does astrology work? We tested the ability of 152 astrologers to see if they could demonstrate genuine astrological skill.

Here is how the study was designed and what we found (including a result that really surprised me):

🧵

[Chris Cassa @ccassa]

@WBUR covered the @CambMA 2 year bike lane delay with Councilors Pickett and @VoteJivan. I made it on the radio for a quick minute as well! 📻 It's an interesting discussion. Some brief thoughts below. @cambbikesafety @StreetsBoston @WalkMass @MassBike https://t.co/lDY9XOKIyp

[MrBeast @MrBeast]

I’m gonna give 10 random people that repost this and follow me $25,000 for fun (the $250,000 my X video made)

I’ll pick the winners in 72 hours

[Sebastian Akle @AkleSebastian]

@doctorveera Agree! This has been my favorite talk

[Chris Cassa @ccassa]

I’m excited to share REGatta, a project by @James_D_Fife from @CassaLabBWH which uses biobank data to estimate the clinical risk of rare variants within regions of established disease genes – Open access link @AJHGNews https://t.co/pIzkntNXrk 🧵

[Sasha Gusev @SashaGusevPosts]

A 🧵 on algorithms for predicting regulatory variant effects to help understand complex disease. IMO an extremely challenging problem that's at a glass mostly full / glass mostly empty point right now depending on who you ask.

[Björn Schumacher @schumacherbj]

Our DREAM paper is out: We found the first master regulator of DNA repair capacities! Read and re-tweet now: The DREAM complex functions as conserved master regulator of somatic DNA repair capacities, @CECAD_ @UKKoeln @UniCologne
https://t.co/rVMe4rAxaf

[Sebastian Akle @AkleSebastian]

@dr_srishtin Ooo. Which Uwc?

[David Sinclair @davidasinclair]

6 day fast has longer lasting metabolic benefits than a 2 day fast. Amazing. Hoping someday to achieve a 1 day fast https://t.co/JsibE44m7b

[Sebastian Akle @AkleSebastian]

😮😮 I thought people were bad at RNG

[Aella @Aella_Girl]

Imagine a circle, with a little spinner on it that you can flick. The circle is 80% red and 20% yellow, like a yellow pie slice.
You flick the spinner. It spins, and slowwwly stops.
Where did it land?

[Sebastian Akle @AkleSebastian]

@jgschraiber @HollyDunsworth Yeah I don’t really see an issue. Except the exclusive focus on the maternal lineage

[Sebastian Akle @AkleSebastian]

@clara_albi Very cool! All three homozygous genotypes have lower expression than the Hets. Was that known? Are there explanations?

[James Shedden @jamesshedden]

Stopping for a moonlit drink

[Omar Wasow | @[email protected] @owasow]

“It seemed absolutely crazy. The idea that an Iowa housewife, equipped with the cutting-edge medical tool known as Google Images, would make a medical discovery about a pro athlete who sees doctors and athletic trainers as part of her job?” https://t.co/iELohgpQHH