Alex Alexander

Medical Microbiologist, MD
Exploring new antimicrobial susceptibility testing and collecting phages

[Alex Alexander @AlexAle88405739]

@JGPharmD There is a CDC Alert
https://t.co/O5A7ervM77

[Alex Alexander @AlexAle88405739]

@jonbachna_PAST Convoluted from the perspective of testing or dosing? Same principle than aztreonam + caz/avi and MBL

[Alex Alexander @AlexAle88405739]

11 clinical isolates of A. baumannii DTR against the last active b-lactams: cefiderocol, sulbactam/durlobactam and our in-house synergy amp/sulb + caz/avi. Tetracyclines as reference. OXAs are the main problem.
Amp/sulb and mero + 1 more resistant agent = DTR.

[Alex Alexander @AlexAle88405739]

@ajosephnotts Non-Infection Related Pyuria (NIRP)

[Alex Alexander @AlexAle88405739]

@MazdaUSA PHEV. Mazda shows offers an hybrid version of each model. Also, less copying BMW and more sport/Zoom-Zoom designs

[Alex Alexander @AlexAle88405739]

@Mazda_Europe Is it coming to US and when?

[Alex Alexander @AlexAle88405739]

@wfwrighID Azt+caz/avi testing, E. coli could carry an NDM

[Alex Alexander @AlexAle88405739]

@drraghutg @Desert_PharmD @accpinfdprn That Staph with MIC 2 should be confirmed by other methods, especially BMD.

[Medical Affairs - MicroGenDX @ma_microgendx]

It is essential to understand the impact the vaginal microbiome exerts over the atypical changes seen in cervical dysplasia due to HPV infection. A proper comprehensive microbiome analysis and intervention should be part of the evaluation. https://t.co/zkKObRmpff

[Alex Alexander @AlexAle88405739]

Just the fact a significant amount of IE causing pathogens are fastidious or unable to grow on culture, molecular testing should be a routine part of the diagnostic process.

[Medical Affairs - MicroGenDX @ma_microgendx]

In an infective endocarditis (IE) study from 44 patients’ resected heart valves that compared NGS, blood culture, and valve Gram staining, NGS proved to be faster and more sensitive with a better negative predictive value (NPV) than the other two methods.
https://t.co/WEJwU5Yj8y

[Alex Alexander @AlexAle88405739]

@dr_avreen @microgendx @w_witthaus @niteshkuro @GoumasUrologia @ArunkumarDr @DrParimalGharia @Mohamedendourol @AnilElhence @drnmreddy @optionurol @UroZedman @docdilipmishra @so_uro Interesting case.
Detection of resistance markers, especially b-lactamases may guide treatment with new BL/BLI. A presence of KPC may prompt the use of mero/vabor, caz/avi, imi/rel, but a MBL as NDM, the use of cefiderocol or aztreonam+caz/avi.

[Alex Alexander @AlexAle88405739]

@dr_avreen @niteshkuro @GoumasUrologia @ArunkumarDr @DrParimalGharia @Mohamedendourol @AnilElhence @drnmreddy @optionurol @UroZedman @docdilipmishra @so_uro Interesting case.
Detection of resistance markers, especially b-lactamases may guide treatment with new BL/BLI. A presence of KPC may prompt the use of mero/vabor, caz/avi, imi/rel, but a MBL as NDM, the use of cefiderocol or aztreonam+caz/avi.

[AdventHealthMD @AdventHealthMD]

Learn more about this groundbreaking new diagnostic tool and the amoebas that cause these life-threatening infections: https://t.co/k0bnIchhcY

[Alex Alexander @AlexAle88405739]

@JGPharmD We always report the asexual form (candida) in clinical results, since they are the known ones.

[Alex Alexander @AlexAle88405739]

@JGPharmD It is, but see it in this way. If you set a candida (yeast) at 30°C instead of 35°C, it will grow as a mold (teleomorph) that is the sexual form. If you set it at 35°C grows as a yeast (asexual).
Most sequencing data for mold have the sexual name and some in the MALDI

[Alex Alexander @AlexAle88405739]

@JGPharmD Aren't those revised names the teleomorph name of the candidas? I believe that's the name of the sexual stage of the fungi, where candida is the asexual one. Every candida has 2 names based on the reproductive state of growth

[Alex Alexander @AlexAle88405739]

@Helezhelm @osama_oj1 They can't. They don't have the right to characters or stories from the 1st age. They can show only those referenced in the 2nd age material they got the rights.

[Alex Alexander @AlexAle88405739]

@drguillezabala Would be interesting to see Fosfomycin MIC. Aztreonam + caz/avi could be an option.

[Alex Alexander @AlexAle88405739]

@wfwrighID Our protocol call for carbapenemase PCR screening on ceftolozane/tazo I or R isolates with MDR pattern. Azt S is interesting, seems a little off. If confirmed, seems a porin + AmpC expression more than efflux.
We have around 3% CP-producing on P. aerug MDR, mostly VIM, few KPC

[Alex Alexander @AlexAle88405739]

@EmpiricGame @theIDPharmD @SanjatKanjilal E. coli carry AmpC gene and they become expressing by a damaged or mutated inducer gene (AmpR). E. coli doesn't have the capability of regulate AmpC expression as the SPICE-M group.