És possible que allà on nosaltres llegim ‘Primer l’amor, després la tècnica’ ells llegeixin ‘Primer el dret de conquesta, després la tècnica de l’extracció’?
Somali referee Omar Artan, who was set to be the first from his country to officiate at the World Cup finals, has been denied entry to the United States.
📺 TV en DIRECTO | El Papa lanza un mensaje contra el aborto en el Congreso: "Toda vida debe ser reconocida y custodiada desde su concepción" https://t.co/glQEolZ0pk
Presented at #ASCO26:
Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: https://t.co/xwLWBZYRzq
@ASCO
#ASCO26
This one is special.
This is the hottest paper of 2026 and potentially in the history of pancreatic cancer.
Let’s dive in.
RASolute 302: Daraxonrasib vs investigator’s choice chemotherapy in previously treated metastatic pancreatic cancer
Abstract LBA5 (soon!)
Presentation: May 31, 2026, 3:21-3:33 PM CDT
For decades, pancreatic cancer has been where good ideas go to die.
We have optimized chemotherapy. We have sequenced chemotherapy. We have celebrated modest gains.
But the central driver of PDAC has always been sitting there in plain sight:
RAS.
More than 90% of pancreatic cancers have oncogenic RAS mutations, and until recently, we had essentially nothing direct to do about it.
Daraxonrasib is an oral RAS(ON) multiselective inhibitor targeting the active GTP-bound state of mutant and wild-type RAS.
And in RASolute 302, it delivered.
Quick hits:
📌 Phase 3 international randomized trial 500 patients with previously treated mPDAC Daraxonrasib vs investigator’s choice chemotherapy
🧬 RAS G12 population
91.8% of patients had RAS G12 mutations
📈 OS in RAS G12 population
13.2 vs 6.6 months
HR 0.40
P<0.001
📈 OS in overall population
13.2 vs 6.7 months
HR 0.40
P<0.001
📊 PFS in RAS G12 population
7.3 vs 3.5 months
HR 0.45
P<0.001
📊 PFS in overall population
7.2 vs 3.6 months
HR 0.49
P<0.001
🔥 12-month OS
Overall population: 53.2% vs 17.3%
⚠️ Toxicity matters, but this was not just more efficacy for more toxicity
Grade ≥3 AEs: 61.8% vs 69.6%
TRAEs leading to discontinuation: 1.2% vs 11.2%
This is the kind of survival curve we almost never get to see in pancreatic cancer.
This validates RAS(ON) inhibition in the most RAS-addicted major cancer. It takes a target we have talked about for decades and turns it into a clinically meaningful survival benefit in a randomized phase 3 trial.
The next questions come fast: 1L combinations, maintenance, perioperative disease, sequencing, resistance, toxicity management, and whether this becomes a new backbone.
RAS is here, and it couldn’t have come sooner.
https://t.co/Y4WJRlRRTk
@TheGutonclab@UGrewalMD@TimothyJBrownMD@OncoAlert@Onco_Nexus@ASCO@NazliDizman@LauraAlderMD@DVAraujoMD@DrBarbiOnc@LauraEsfeller@FunchainMD@YGaritaonaindia@DrSAHaddad@jgong15@iandresmeraz@SakditadMD@RamilaShilpakar@RohitBanwar@lungoncdoc
La protesta dels metges puja de to: una trentena d'hospitals deixen de fer hores extres a partir del juny https://t.co/hRapCsMrlY https://t.co/hRapCsMrlY
Ho heu demanat i ho fem: ampliem els Préstecs Emancipació de 35 a 40 anys. Fins a 50.000€, 0% d'interès, que es retornaran un cop pagada la hipoteca.
La nostra prioritat és garantir el dret d’accés a l’habitatge i amb polítiques com aquesta fem un pas més per aconseguir-ho.
📈 Avui presentem el pressupost de Salut amb fons addicionals per al 2026, el més alt de la història.
🔜 Una inversió per impulsar la transformació del sistema i garantir-ne la sostenibilitat econòmica.
🤝 És un pressupost que posa les persones al centre: per cuidar-les millor, reduir les esperes i reforçar el nostre sistema públic en un moment exigent.
🚨 BREAKING: Barcelona reach an agreement in principle with Newcastle to sign Anthony Gordon. £70m plus bonuses.
Barcelona have pencilled in a medical for this week and anticipate the deal is formalised quickly.
Bayern expected to lose out despite also agreeing terms with Gordon.
Liverpool never made a move despite historical interest.
🤝 @alex_crook
🚨 Degoteig d’adhesions a la campanya 'Ni un minut més': diferents serveis d’11 hospitals públics deixaran de fer activitat extra a partir de l’1 de juny
https://t.co/uMqa9okxpe