Alex LeNail

Postdoc in George Church's lab at HMS/Wyss. Prev MIT CSB PhD.

[Longevity Biotech Fellowship @LBF_org]

Happy to announce we've selected @AlexLeNail as one of our Fellows for LBF's upcoming cohort in North Carolina (LBF8).

Alexander is a Harvard Medical School postdoc developing transcription-factor gene therapies to treat brain aging.

[Alex LeNail @AlexLeNail]

@jamesfickel When we look back, this portfolio of projects will have been some of the defining scientific projects in this period. Bravo on finding & backing such a high density of excellent teams working on the foundations of tomorrow.

[James Fickel @jamesfickel]

The Foundations of Tomorrow

The transition to AGI needs to go well. We’ve deployed $350M+ to neuroAI, longevity, and more with the belief that the brain is the key to better, safer AGI. This is the first of many overview posts on our thinking.

https://t.co/NlwpDPD53E

[Angelica Parente @draparente]

Not sure why this isn’t bigger news.

The NIH SBIR/STTR programs lapsed on October 1, 2025. No new grant solicitations can be authorized. The tremendous value these funding sources bring to our nation’s economy isn’t contested, but there’s an impasse about how the program should be structured.

A year extension was authorized with bipartisan support by the House, but it’s stalled in the Senate. #HR5100

https://t.co/WDrCOIPLlA

[Richard Hanania @RichardHanania]

Man comes to the US from Lebanon. Starts out delivering pizzas, becomes a Nobel winning neuroscientist. Trump freezes his funding, he gets an email from China offering to move his lab “any city, any university I want" with guaranteed funding for 20 years.

What are we doing?

[Jake Wintermute 🧬/acc @SynBio1]

Every synthetic biologist, every biochemist, when they dream, will sometimes hear a voice calling

A whisper on the wind, as impossible as infinity, as sweet as the ambrosia of the very Gods

"Engineer RuBisCo"

And this paper takes us one step closer
https://t.co/xS0ns6UGlY

[Internet Archive @internetarchive]

📚 Attention Readers & Researchers 📚

More than 500,000 books have been removed from our lending library due to the publishers' lawsuit. Have you been affected? Share your story with us and help us fight to restore access. #LetReadersRead

👉 https://t.co/vKaRSR5Tmu

[Alex LeNail @AlexLeNail]

I'm immensely grateful to the @PhRMAfoundation for supporting me, my journey, and my work. I hope our approach to enhancing neuronal resilience to aging & degeneration turns out to be an effective one.

[PhRMA Foundation @PhRMAfoundation]

#PhF24 awardee @AlexLeNail of @MIT is conducting research that aims to forestall the onset of #brain diseases by fortifying neurons' ability to maintain their health during #aging.

Hear Alex's journey in the full interview: https://t.co/BtZb7K9m9f

@mitbrainandcog @MITBiology

[Alex LeNail @AlexLeNail]

I'm hopeful that instigating repair of aging-related molecular damage in neurons will prove to be an effective way to treat multiple neurodegenerative diseases. I'm very grateful for the support from Amaranth so we can find out whether that's the case.

[James Fickel @jamesfickel]

This report is the months-long culmination of some of the brightest young leaders in the longevity field coming together to prioritize and detail the field’s top bottlenecks:

https://t.co/TLzuIZxnga

[Alex LeNail @AlexLeNail]

@DaniBeckman @ImarisSoftware Are these data published? Are you publishing them soon? I'd love to see statistics

[Sam Goldman @samgoldman19]

Protein structure prediction has been “neuralized,” but what about small molecule structure prediction from spectra?

Excited to share our new preprint, Annotating metabolite mass spectra with domain-inspired chemical formula transformers. 1/5

https://t.co/mqYB6Ra5WX

[Noam Prywes @NoamPrywes]

Here at @SavageCatsOnly we are thrilled to present a review on rubisco. We focused on structure, mechanism, evolution and engineering attempts. We try, and fail, to conclusively answer the question "What exactly is holding this enzyme back?" 1/10

https://t.co/jCxMOlSPX8

[Erika Alden DeBenedictis @erika_alden_d]

Biology should, can, and will be more like software engineering. The 2022 Bioautomation Challenge is going to kickstart that transformation. I can’t wait to see what people come up with! https://t.co/IHvWzFJBoZ

[Dr. Chris Rackauckas @ChrisRackauckas]

I am very happy to announce SciMLCon 2022. It's more than just a conference for #sciml @SciML_Org, it's also a start of the exponential expansion of #julialang conferences. For more on the total vision, please check out this Discourse post:
https://t.co/3Wt6Csx74Q

[Joseph Replogle @josephmreplogle]

I'm thrilled to share our latest work performing genome-scale Perturb-seq screens to explore a remarkable breadth of questions in genetics and cell biology (thread below). Congrats to Reuben Saunders, Tom Norman, and @JSWlab for co-leading this work. https://t.co/SRyvVGImJh

[Alex LeNail @AlexLeNail]

@mferraro89 What js library are you using here for 3d?

[Alex LeNail @AlexLeNail]

How do you learn ODEs which describe timeseries data? (e.g. a chemical reaction network?)
https://t.co/miNHWslfXf

[Elin Videvall @ElinVidevall]

Bioinformatic pipelines

[Alex LeNail @AlexLeNail]

@drmichaellevin Related but not exactly: https://t.co/w9IHX1UJkW

[Alex LeNail @AlexLeNail]

@AllenInstitute Were the talks...recorded?