Alex Pollatos

PhD Candidate @BaranLabReads | @RiceUniversity Alum
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[Alex Pollatos @AlexPollatos]

If you've noticed electrochemistry showing up in more and more total syntheses, our new review is for you! Electrosynthesis has been around for decades, but its role has only recently taken off – we cover how it went from niche tool to go-to strategy.

[Baran Lab @BaranLabReads]

Electrochemistry Goes Mainstream: Applications in Modern Total Synthesis, a review appearing today in @ChemRxiv :https://t.co/x4afIZCOLL

[Philipp Neigenfind @pneigenfind98]

Thrilled to share our new preprint in @ChemRxiv, in which we unveil a new avenue to access valuable scaffolds for drug development that were previously virtually inaccessible. Huge thanks to all our collaborators for making this work possible!

[Alex Pollatos @AlexPollatos]

@AugustLamm How do you handle 2FA?

[Scott Bagley @BagPhos]

UPLC vs TLC

[nɹnznʎ @yuzururururu]

The final version of this work has appeared today in @J_A_C_S
A General Three-Component Alkyl Petasis Boron–Mannich Reaction | Journal of the American Chemical Society https://t.co/3WMRt8Vm0J

[30-Year-Old Tooth Fairy Believer @DCC_DMAP]

Chemistry is puzzling over a boc group that survived 4 M HCl/Dioxane overnight

[Angewandte Chemie @angew_chem]

#TotalSynthesis of Dragocins A-C through Electrochemical Cyclization (Phil S. Baran and co-workers) @BaranLabReads https://t.co/YCUW2OmhAi

[Alex Pollatos @AlexPollatos]

@geordifrere Reetz’s work was ahead of its time! Shameless self-plug if you are interested in more variants of this transformation

https://t.co/Hb4ePnqFy2

[Gui Lab @Jinghan_Gui]

Thrilled to summarize our bioinspired skeletal reorganization approach for the synthesis of steroid natural products in Acc. Chem. Res. Credit to @yuwang175 for writing this Account. Big thanks to members of my team for their great contributions: https://t.co/2TPxHXhSyp

[Alex Pollatos @AlexPollatos]

@pushingarrows @AlbertoFGC Thank you Dr West!!!

[Alex Pollatos @AlexPollatos]

Thrilled to have played a role in the implementation of electrochemistry in this beautiful synthesis! Pleasure to work alongside my friends and colleagues Brendyn, Nate, and @AlbertoFGC

[Baran Lab @BaranLabReads]

⚡️An electrifying total synthesis to start 2024⚡️! The total synthesis of Dragocins A-C appearing today in @ChemRxiv: https://t.co/5HgstoLc05 . Happy New Year! 🥂

[kaid harper @KaidHarper]

Our work on scaling electrochemistry via constant potential is out. Give it a look
A Scalable Solution to Constant Potential Flow Electrochemistry | ChemRxiv - https://t.co/fHimr2arv5

[Alex Pollatos @AlexPollatos]

Love me a good peptide! Congrats to Fabian and the team!!

[Baran Lab @BaranLabReads]

ONE (aziridine) RING TO RULE THEM ALL! The total synthesis of Dynobactin A, appearing today in @ChemRxiv: https://t.co/NgeYC4B8zS

[Alex Pollatos @AlexPollatos]

A tour de force! Congrats to @ManoliSofiadis , @Dongmin_Xu , and Anthony on conquering the κύκλωπας!

[Baran Lab @BaranLabReads]

CYCLOPAMINE! A total synthesis with LEO Pharma collaborators. Appearing today in @ChemRxiv : https://t.co/u8y2RMQsPy

[Baran Lab @BaranLabReads]

"Dump, stir, electrify" - Quaternary centers made easily through decarboxylative arylation of tertiary acids with (hetero)aryl bromides. Appearing today in @ChemRxiv: https://t.co/twIsOiaD3j. A super fun collaboration with BMS, Biogen, LEO Pharma, and Enamine.

[Shenvi Lab @Shenvi_Lab]

Happy to share on ChemRxiv our stereoselective synthesis of (–)-eugenial C via MHAT/SH2 iron catalysis. https://t.co/AwELeO5ozx
It took trial and error, rational design and even a little citizen science to locally source our starting material (thanks @SDNHM Plant Atlas!!).

[Doron Pappo @PappoDoron]

A significant step toward the biomimetic synthesis of vancomycin and other glycopeptide antibiotics.
In our new @chemRxiv preprint, we present a selective multicopper(II) cluster-catalyzed oxidative phenol macrocyclization (OxPM) of linear peptides.
https://t.co/L4QwkADxWN

[Alex Pollatos @AlexPollatos]

@JJSabatini how about we throw some nitros on here?

[Alex Pollatos @AlexPollatos]

So many nitrogens it's almost energetic!

Congrats Cheng! Truly a piece of art

[Baran Lab @BaranLabReads]

Got Nitrogen? A concise enantioselective synthesis of the marine-derived alkaloid KB343 is disclosed today in @ChemRxiv: https://t.co/gU7mtDsnkl.

[Baran Lab @BaranLabReads]

Today we report in @ChemRxiv a scalable solution to the total synthesis (and structural reassignment) of the Portimines (https://t.co/UYahP1Hmv2). In collaboration with @_chrisgparker_ and Luke Lairson the remarkable biological activity of this natural product family was revealed