Alex Walker

Postdoc with @PeterJCullen @BristolBiochem, formerly postdoc @YamauchiLab @CMMBristol and DPhil Student @fodorlab @Dunn_School. Biology 🦠🧬 and food! 🍕🥐

[Alex Walker @AlexWalkerPath]

Really glad to contribute to this work led by the crazy-talented (although not on social media!) Rebeka Butkovic 🎉 An exciting first step into the fascinating world of cell biology! 🧪🧫

[Fodor Laboratory @fodorlab]

Using virion vRNPs, together with purified proteins, we have, for the first time, recreated the switch from influenza virus transcription to replication, AND a full cycle of genome replication inside a test tube🧪@AmandaZihanZhu @haitian_fan @PLOSBiology
➡️https://t.co/ngGrqKZSut

[Kerrie McNally @KerrieMcNally1]

Delighted to share that our structure of the endosomal Commander complex is now published in @CellCellPress! https://t.co/o9Tg1m4kHZ

[Fodor Laboratory @fodorlab]

The tale of influenza viruses Part II: Molecular Replication, sister to its transcription-focused Part I, is now aired online in Trends in Microbiology!

Click here ⬇️ to check out the most recent structural updates on influenza virus genome replication!

https://t.co/kWePWLh7N9

[Alex Walker @AlexWalkerPath]

Ready for #NSV2022 after a cancelled flight led to an unexpected journey to Heathrow airport! ✈️ Excited to catch up with old friends and make some new ones!

[Haitian Fan @haitian_fan]

Our study on a novel role of host factor ANP32 in influenza virus genome replication has been published on @NAR_Open https://t.co/I01xQ8W0qg, congrats everyone involved @FangzhengWang @Dr_Shepp @StallerEcco @wendybarclay11 @jonathan_grimes @fodorlab @Dunn_School @OxfordStrubi!

[Alex Walker @AlexWalkerPath]

Glad to see this out, congrats everyone!

[Lia Yosaatmadja @shotliverfreak]

Our NSP14 baby https://t.co/hU1ngHXAcI is finally out today @NAR_Open. Can't thank @JeremyKeown1 @haitian_fan from @fodorlab and @jonathan_grimes lab, @SchofieldOxford , @ogileadi and McHugh lab enough for their support and hard work to get this to the finish line ❤️.

[Fodor Laboratory @fodorlab]

In a world where viruses, scientists and llamas co-exist…. happy to share our work in collaboration with Grimes' lab, on mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies produced in llamas. Check it out!
https://t.co/9F79q4hNu0

[Jeremy Keown @JeremyKeown1]

Really happy to see this piece of work out. With @amandaz83411502 we structurally and functionally characterised 24 nanobodies against the 1918 influenza virus polymerase. @fodorlab @jonathan_grimes @OxfordStrubi @Dunn_School https://t.co/yJMEWLBlx8

[Alex Walker @AlexWalkerPath]

Just out today, our contribution to understanding #SARSCoV2! We show that the viral polymerase is involved in capping the viral RNA. With thanks to @fodorlab @haitian_fan @JeremyKeown1 @M_L_Knight @jonathan_grimes
https://t.co/TdnKXIww6n

[Jeremy Keown @JeremyKeown1]

It's Flu awareness week and @DiamondLightSou arranged for an animation of some of our recent work on the influenza polymerase. @CarriqueLoic @AlexWalkerPath @jonathan_grimes @fodorlab @StallerEcco @OxfordStrubi @Dunn_School

[Fodor Laboratory @fodorlab]

Congratulations to Alex @AlexWalkerPath on passing his DPhil viva @Dunn_School ! Enjoy your postdoc in Bristol with @YamauchiLab !

[Jeremy Keown @JeremyKeown1]

Nice work @M_L_Knight @haitian_fan @fodorlab @OxfordStrubi.

[Fodor Laboratory @fodorlab]

Alex @AlexWalkerPath from @Dunn_School presents his work on SARS-CoV-2 RNA capping at @MicrobioSoc #Microbio21. See https://t.co/ikEjYZDfFw for details.

[Alex Walker @AlexWalkerPath]

New preprint alert 🚨 Our latest SARS-CoV-2 work, showing that one of the domains in the viral RNA polymerase is an enzyme involved in viral RNA capping (and this reaction is inhibited by remdesivir TP)!

[Fodor Laboratory @fodorlab]

Identification of guanylyltransferase activity in the SARS-CoV-2 RNA polymerase https://t.co/J5FsALscfy

[Fodor Laboratory @fodorlab]

Another stunning talk from @AlexWalkerPath on how 'mutation of a Flu polymerase 3' RNA promoter binding site inhibit transcription elongation' was delievered! Great work! #IUM2020 #Influenza

[Fodor Laboratory @fodorlab]

Socially distanced cake celebration for our @nature paper https://t.co/qvO5gMIoTZ 🎉 Congratulations again to all first authors @CarriqueLoic @haitian_fan @JeremyKeown1 @AlexWalkerPath @jonathan_grimes and Ervin!
#influenza #cake

[Alex Walker @AlexWalkerPath]

We present the first structures of influenza virus polymerase bound to an essential host factor, and these give us some amazing insights into how the #flu virus replicates/adapts for new hosts! Congratulations everyone @CarriqueLoic @haitian_fan @JeremyKeown1 @jonathan_grimes

[Jeremy Keown @JeremyKeown1]

https://t.co/2q8L6ElhAE
@CarriqueLoic @haitian_fan @AlexWalkerPath @jonathan_grimes #notontwitterErvin. We solved a series of structures using #cryoEM of the ANP32-Influenza polymerase complex, and investigated it using functional assays. @OxfordStrubi @Dunn_School @NDMOxford

[Dunn_School (now @DunnSchool.bsky.social) @Dunn_School]

Many congratulations to all the winners at today's Graduate Student Symposium! 🏅🏅🏅

1st year poster prize: Shengpan Zhang (Sattentau group)

2nd year poster prize: @RuthKetley (Gullerova group) and @lu_fangfang (@freeman_lab)

3rd year talk prize: @AlexWalkerPath (Fodor Group)

[Dunn_School (now @DunnSchool.bsky.social) @Dunn_School]

Our virtual progress seminars continue! Last week Nandita Bodra @LeaLabTweets talked about structural work on the complement system. Yesterday, Florian Zobel @IvanAhelLab discussed PARP1 and tomorrow @AlexWalkerPath (Fodor lab) tell us more about his #COVID19 research