AlexanderSHatoum

Psychiatric, statistical, and imaging geneticist. Interested in translational methods and modeling addiction comorbidity. WUSM Psych. Tweets are my own. He/His

[AlexanderSHatoum @AlexanderHatoum]

Preprint alert:
https://t.co/vJGDUO0qc4
TL;DR Biotech practices taking a handful of genetic variants and training a #MachineLearning #ML #AI model are based on unsound science, and will lead to medical discrimination. We demonstrate this with Opioid Dependence (OD)....

[AlexanderSHatoum @AlexanderHatoum]

Hello all! I've made the move over to BlueSky, Find me @alexanderhatoum.bsky.social. I'll be deleing this account in the next week.

[AlexanderSHatoum @AlexanderHatoum]

More at this link!
https://t.co/wy9Culk2Ta

[AlexanderSHatoum @AlexanderHatoum]

I'll be teaching at the JAX Lab Short course on the Genetic of Addiction. Check it out if you want to advance your knowledge on a range of topics from animals and human genetics.

[Boris Chaumette @BorisChaumette]

I’m proud to have co-signed this letter of concern, published today in @TheLancet Psychiatry, alongside 140 international experts in psychiatric genetics. Innovation should benefit patients without causing greater harm.

#WCPG2024 @AlexanderHatoum

https://t.co/BZF56L1PtL

[Sarah Paul @spaul1124]

Excited to share that this manuscript has now been published @NatMentHealth! https://t.co/EGfRY5Dg2S

[PGC Consortium @PGCgenetics]

SUDs are heterogenous concepts. To understand genetic effects on SUDs, we need to contextualize genetic effects on behavior, brain, and development. In this review, Bogdan and Colleagues develop a framework for contextualizing discoveries in SUDs.
https://t.co/2IYH0pn9eZ

[PGC Consortium @PGCgenetics]

A study led by @e_covey_johnson examined genetic relationships among schizophrenia, cannabis use, and cigarette smoking. The study identified 327 pleiotropic variants (150 novel) and provided insight into shared genetic factors and potential causal links.
https://t.co/PASV10HKrH

[PGC Consortium @PGCgenetics]

📝📝Pop Quiz: One of the largest effect sizes of any SNP on a polygenic trait influences behavior (#2 after hair color), can you guess the trait and gene? 📝📝

(Hint: This is the PGC substance use disorder takeover)

[PGC Consortium @PGCgenetics]

📢 New study led by Christal N. Davis, and colleagues reveals that candidate genes from an FDA-approved algorithm fail to predict opioid use disorder (OUD) risk in over 450,000 veterans. This study raises concerns about the clinical utility of the algorithm in predicting OUD. 🚨

[PGC Consortium @PGCgenetics]

Hi Everyone - the substance use disorders working group (PGC-SUD) will be taking over the @PGCgenetics account for the next two weeks.

Follow along as we share exciting updates and papers, highlight recent news, and spotlight important progress in the field overall. Join us!

[PGC Consortium @PGCgenetics]

In the largest study of problematic alcohol use (PAU) to date led by Hang Zhou of @YalePsych, researchers identified >100 risk variants across multiple ancestral populations and found significant genetic correlations with PAU in non-European individuals.
https://t.co/txwZlubxhc

[PGC Consortium @PGCgenetics]

A study of cannabis use disorder (CanUD) led by @dflevey1 of @YalePsych identified risk variants in each of the studied ancestry groups, found distinctions between CanUD and cannabis use, and helped place cannabis traits among other related health outcomes
https://t.co/Jtra8epbJU

[PGC Consortium @PGCgenetics]

A study led by @AlexanderHatoum found evidence for a generalized addiction risk factor that identified 19 risk variants including variants involved in dopamine regulation, along with many substance-specific variants involving drug metabolism and receptors.
https://t.co/x9n99bifry

[PGC Consortium @PGCgenetics]

A recent preprint led by Christal Davis and Henry Kranzler found no evidence to support the clinical utility of a set of 15 genetic variants that are the basis of an FDA-approved genetic screener for identifying individuals at risk for opioid use disorder.
https://t.co/GHXR53rKvA

[PGC Consortium @PGCgenetics]

In a @PGCgenetics special issue of Psychological Medicine (@CambUP_Psych), PGC-SUD researchers
@e_covey_johnson and @Joseph_Deak provide a review covering the genetics of substance use disorders: https://t.co/jrrJ7HE1le

[PGC Consortium @PGCgenetics]

Congratulations to PGC-SUD researcher @Alex_PMiller on his recently awarded K01 from @NIAAAnews. Alex will examine neurogenetic influences linking impulsivity and alcohol use disorder progression across development at @IUMedSchool and his work with @PGCgenetics and @COGA_alcohol.

[David Baranger @David_Baranger]

Our article exploring the neurobiological correlates of prenatal cannabis exposure is now out! "Prenatal cannabis exposure, the brain, and
psychopathology during early adolescence" https://t.co/aEiDj7j9Kj

[AlexanderSHatoum @AlexanderHatoum]

Led by @Alex_PMiller with input from Arpana Agrawal and @BRAINLab_WUSTL

[AlexanderSHatoum @AlexanderHatoum]

New Review: Here, we discuss the history and logic behind emerging GWAS studies that analyze common genetic risk across substance use disorders. This is part of a larger genetics of SUDs review series by JCI, Check it out!
https://t.co/EC3VDjEmhh

[AlexanderSHatoum @AlexanderHatoum]

@sorandomclaire Have been for years?