Q

[Bryan Johnson @bryan_johnson]

This is biblical.

A woman in her eighties. Ten years into Alzheimer's. Hadn't spoken a full sentence in five years.

Takes one, 5 gram dose of psilocybin.

She slept 19 hours and woke up and spoke for hours about her life, recognized family and held real conversations. She regained bladder control after five years, walked on her own. and dressed herself. Gains held for weeks.

[Kevin Dahlstrom @Camp4]

🚀 The only career advice you need:

The actor Glen Powell auditioned to play Rooster in Top Gun: Maverick.

When the role was given to Miles Teller, Powell was devastated. He was offered a smaller role, but declined.

Tom Cruise summoned Powell to his house and asked him:

“What kind of career do you want?”

Powell responded:

“I want to be like you—an iconic movie star. You always choose great roles.”

Cruise shook his head.

“You’re wrong. I choose great movies, then I make the role great.”

Powell got the message. He accepted the role of Hangman—and nailed it.

Now Powell says:

“It changed the trajectory of my career.”

When young people ask me for career advice, I tell them something similar:

🚀 Attach yourself to a rocketship.

Join companies that are growing quickly. Work with people who are going places. Be part of something great.

Play your role—no matter how minor—exceptionally well.

The rest will take care of itself.

P.S. I don't write engagement bait, so I need your help to spread the word. If you enjoyed this post, would you like, comment, and repost?

[GREG ISENBERG @gregisenberg]

I was once pitching in a board room at a top 3 VC firm for a $15M Series A.

12 people in the meeting. One of the GPs fully fell asleep. Out cold for 30+ minutes. Nobody acknowledged it. Everyone just kept going.

I kept presenting my Series A slides to an unconscious man in a Herman Miller chair and somehow that was considered normal. That's venture capital.

You might fly across the country to perform for people who may or may not be conscious.

It's a dance.

And sometimes you lead and sometimes you follow and sometimes your partner is unconscious.

If you're raising right now, just know: every founder has a story like this. The process is weird. The power dynamic is weird. You're not crazy for thinking it's weird.

No one talks about it because they want to continue raising. But I'm happy to stick my neck out there.

It is weird.

[Chamath Palihapitiya @chamath]

On every metric, American kids are so much dumber than they were 5 years ago and we are grade inflating away the reality.

[Peter H. Diamandis, MD @PeterDiamandis]

The reason most people never start building is the quiet assumption that someone smarter is already working on it, not a lack of skills or capital. Let me tell you, those 'smarter' people are usually not.

[Marc Andreessen 🇺🇸 @pmarca]

“We know that they are lying, they know that they are lying, they even know that we know they are lying, we also know that they know we know they are lying too, they of course know that we certainly know they know we know they are lying too as well, but they are still lying.”

[GREG ISENBERG @gregisenberg]

I can't believe how fun building a company is right now is.

The weird part is it doesn't feel like work anymore. New AI models/tools/repos keep coming out making the impossible possible.

My ONLY anxiety is making sure I don't waste this precious moment and keeping up with the updates of all the new tools/AI models.

AI is creating the greatest platform shift of all time.

And, I've learned to never let a good platform shift go to waste.

I was living in Silicon Valley around for the mobile era. I remember the feeling of "you can just build an app and put it in the store and people find it."

That lasted maybe 4 years before the gold rush ended and distribution got hard.

I'm getting that same feeling right now but bigger. The difference is I'm older, I know what a window looks like, and I know they close.

I love building right now. Maybe you do too. Trying not to take it for granted. I'm excited for Monday. Can't wait.

My partners and I are up at midnight most nights now sending each other screenshots saying "look what this can do." Nobody asks anyone to do this. We just can't stop. Something drops, someone builds something with it in 2 hours, and the group chat goes off. It feels like we're getting away with something.

Some of the greatest companies of the next decade will be started in 2026. I'm sure of it. And it'll be fun.

I feel like a kid again. Genuinely giddy.

[Blake Byers @byersblake]

Many people spent a career in relative obscurity to deliver a breakthrough result in cancer care today. Hoping this drug gets to all the patients that need it as soon as possible/yesterday.

[Peter H. Diamandis, MD @PeterDiamandis]

The opposite of paranoia is pronoia, the irrational belief that the universe is conspiring in your favor. I have built my entire career on pronoia and I highly recommend it.

[The Vigilant Fox 🦊 @VigilantFox]

Bill Maher asks how Mississippi is kicking California’s ass in education, and Texas is “blowing them away” in green energy for “way less money.”

“Did you know that a black fourth grader in Mississippi is two and a half times as likely to be proficient in math and reading as one in California? Mississippi is kicking our ass in education and for way less money. We’re 37th in fourth-grade reading, they’re ninth.”

“Texas is kicking our ass in green energy. The average time to get solar panels connected there is three to four months. About 1,000 days faster than it took me. Remember when I was trying to get my solar hooked up? It would have been quicker to build a windmill.”

“Texas has passed California in solar and blows away California when it comes to wind and energy storage. How does a state with no pro-climate policies produce better climate results than a state where here, even though we have so much better bumper stickers on our Priuses?”

“I’ll tell you why. Because you’re allowed to build there because every third person in Texas isn’t someone whose job it is to make sure nothing gets done.”

“Democrats, these are your issues: education, race, the environment.”

“And I say this with love: you’re losing to the Waffle House, car-on-the-lawn states.”

[Joe Lonsdale @JTLonsdale]

California D leaders are the party of fraud, and they are scared.

[Marc Andreessen 🇺🇸 @pmarca]

Do I hear $300 billion? $500 billion? $1 trillion?

[Nick shirley @nickshirleyy]

CBS News said there was no evidence of fraud.

The NYT said the Somali community was being targeted

CNN said there was "little evidence."

Tim Walz said it was “white supremacy” to expose fraud

Today: $90M busted and 15 charged.

IT WAS ALL FRAUD AND THEY KNEW.

[GREG ISENBERG @gregisenberg]

reminder

[Elon Musk @elonmusk]

True

[Kevin O'Leary aka Mr. Wonderful @kevinolearytv]

Who is messing with anyone who wants to build out the US power grid or add to compute capacity. It’s our friends, the #Chinese government. I’m not the only guy at sounding the alarm!