Alice Buonfiglioli, PhD

Neuroscientist @IcahnMountSinai #neuroimmunology #microglia #glioblastoma #psychiatry #neurodegeneration

[Alice Buonfiglioli, PhD @AliceBuonfi]

Discover how we integrated #microglia into #brain #organoids for the first time to model how immune challenges impact #neurodevelopment! IFN-γ exposure revealed autism-linked gene changes and a microglial potential protective role. https://t.co/4VPh5aSol3

[Alice Buonfiglioli, PhD @AliceBuonfi]

@HaageVc @DanieleMattei4 @RMi11ie

[Alice Buonfiglioli, PhD @AliceBuonfi]

Discover how we integrated #microglia into #brain #organoids for the first time to model how immune challenges impact #neurodevelopment! IFN-γ exposure revealed autism-linked gene changes and a microglial potential protective role. https://t.co/4VPh5aSol3

[Daniele Mattei, PhD @DanieleMattei4]

Mind The Time! What time do you collect #microglia from your preclinical model for downstream analyses? Microglia undergo #transcriptional, #proteomic and #functional adaptations to the wake and sleep phases🧵https://t.co/KOFu1C1BLB

[Alice Buonfiglioli, PhD @AliceBuonfi]

Happy to share our pre-print where we propose an optimized protocol for integrating #microglia into human #brain #organoids to study microglial contributions and the impact of #prenatal risk factors on #neurodevelopment.
https://t.co/JkYIF4L5Z4

[Daniele Mattei, PhD @DanieleMattei4]

Mind the #time! #Microglia undergo #transcriptional, #proteomic, and functional changes between #wake and #sleep phases! What time do you isolate microglia for downstream analysis? @andranik_ivanov @BilgeUgursu @J_Sc18 @JulietRichetto @ulli2512 @meyer_uzh
https://t.co/ruHxzjGqdJ

[Daniele Mattei, PhD @DanieleMattei4]

circular RNAs are increasingly studied for their intriguing regulatory roles in physiology and disease. Our work shows that their expression follows a circadian pattern! This is crucial to keep in mind for future preclinical and clinical studies.
https://t.co/YFeHtANOkj

[Alice Buonfiglioli, PhD @AliceBuonfi]

Tumor-associated microglia and macrophages support tumor proliferation, regulate immunosuppression and contribute to cerebral edema. In a way,TAMs protect the tumor just as Cerberus guards the underworld.Check our latest review on #TAMs function in #Glioblastoma @HambardzumyanL1

[The NeuroNetwork @TheNeuroNetwork]

Macrophages and microglia: the cerberus of glioblastoma

A new review published in Acta Neuropathologica Communications from @AliceBuonfi and @HambardzumyanL1

https://t.co/AakvRSwQ35

[Daniele Mattei, PhD @DanieleMattei4]

Here's what happens to neurodevelopment in a model of GPI anchor deficiency! This great collaborative work is finally out!

[Daniele Mattei, PhD @DanieleMattei4]

Please, mind the Temperature! Proud to share our optimized brain tissue dissociation protocol at 4°C and our systematic comparison with standard enzymatic digestion!
https://t.co/LrDrG0nETB

[Miguel Rodríguez de los Santos @RodrigMig]

Very happy to share my PhD work on #BioRxiv! :)
We show in a mouse model for #GPIBD a hippocampal #synaptopathy accompanied by motor, social and cognitive alterations.
Many thanks to all the co-authors...
@marionrivalan @LabSchmitz @MundlosLab @DanieleMattei4 @3u_1e @pnrobins

[Alice Buonfiglioli, PhD @AliceBuonfi]

If you're curious about the role of the let-7 #miRNAs as #TLR signaling molecules in #microglia in health and #glioma, check our new paper out now in @CellReports from the Kettenmann's lab @MDC_Berlin and the Lehnardt's lab @Charite https://t.co/vHcXCzs7rE

[Nature Portfolio @NaturePortfolio]

The second recorded case of a patient experiencing remission from HIV-1 infection after stem-cell transplantation is reported in Nature. https://t.co/vPoPfEIGcC

[Gutmann Laboratory @GutmannLab]

Wonderful to work with my colleagues at the MDC in #Berlin to identify #microglia markers to study #braintumors.