Alice Stanton

Accelerating drug discovery & delivery for neuro | Stanton Lab at MGH & Harvard Med | mini-Brain on-Chip ✨️

[Alice Stanton @AliceStanton]

Ever dream of a mini-brain model that is fully vascularized? Wonder if we could build a BBB + myelinated neuron + immune components all-in-one 3D brain tissue mimic? Our team took on this challenge and we are happy to share it with you now🧠https://t.co/ZK3ibI98or

[Alice Stanton @AliceStanton]

Are you an ambitious young scientist motivated to improve brain health? Do you have a strong background in molecular biology, iPSC technology, or nanotechnology? Come join our team!

We have several positions open in exciting project areas, including at technician, graduate student, and postdoctoral levels.
Technician - delivery to the brain: https://t.co/OOU3979Eqj
Technician - iPSC based brain model: https://t.co/ujddBkAulz

Graduate students and postdocs can email me at aestanton [at] https://t.co/U3fJmvLAxj and include "Graduate Student" or "Postdoc" in the subject header.

[Alice Stanton @AliceStanton]

Can lab-grown 'mini-brains' combined with artificial intelligence help scientists quickly find new drug targets for Alzheimer's disease? This is what we will ask thanks to support from the @alzassociation .

Alzheimer's disease already affects millions of Americans, and that number is expected to nearly double by 2050. Despite decades of research and the discovery of more than 70 genetic risk locations linked to the disease, there is still no medication that can stop or reverse the brain damage it causes. One major reason progress has been slow is that Alzheimer's involves complicated interactions between many different types of brain cells, not just neurons, and most lab models used to study the disease, such as mice, don't fully capture how these cell types work together or how human-specific genetic risk factors behave.

To address this we will utilize our lab-grown 'mini-brain' miBrain organoids, combining all six major brain cell types, including neurons, immune cells, and blood vessel cells, grown from human stem cells, to study how specific genes affect Alzheimer's-related damage.

We thank the #AlzheimersAssociation for their support as we continue the fight against #AD and #ADRD.

[Alice Stanton @AliceStanton]

Come be our colleague in the most fantastic of environments!

[CGM at MGB @CGM_MGH]

The CGM @ MGB has launched a faculty search in Genomic Medicine and Neuroscience. Apply today! https://t.co/1hcbQO36U2

[Alice Stanton @AliceStanton]

@NIH_CommonFund @NINDSfunding @MGBResearchNews @harvardmed @CGM_MGH @MIT @kochinstitute @broadinstitute The Stanton Lab exists to invent technology to improve treatments. We have a lot of important science ahead.
https://t.co/fxZPMolDkf

[Alice Stanton @AliceStanton]

Thrilled and deeply honored to share that I have received the NIH Director’s New Innovator Award.

With this support, the Stanton Lab will launch “Therapeutic Discovery in Neurodegeneration with Bioengineered Organoids and AI-Genomics.”

https://t.co/dmudkDNCa3

[Alice Stanton @AliceStanton]

@NIH_CommonFund @NINDSfunding Thank you to my mentors, collaborators, and the extraordinary community at @MGBResearchNews, @harvardmed, @CGM_MGH, @MIT, @kochinstitute, @broadinstitute, & beyond who made this possible. Most of all, thank you to the scientists and engineers already building this future with me.

[Aptar @aptar]

Aptar Pharma and Massachusetts General Hospital announce research collaboration to advance predictive, data-driven models for #NoseToBrain #DrugDelivery and support future CNS pipelines. Learn more: https://t.co/SyKyLT19BM #AptarPharma

[Alice Stanton @AliceStanton]

https://t.co/LFInUMgJhR @CGM_MGH @MGHNeurology @MGHMartinos @harvardmed @MIT @broadinstitute

[Alice Stanton @AliceStanton]

Excited to share a new collaboration with @aptar: we’re building a predictive platform for nose-to-brain drug delivery.

The blood-brain barrier stops most CNS candidates. The nose offers a direct route, but we need better tools to optimize for its delivery of medicines. Link:

[Alice Stanton @AliceStanton]

@Nanohappiness1 Thank you Min!

[Alice Stanton @AliceStanton]

The Stanton Lab exists to invent technology to improve treatments. We have a lot of important science ahead.
#NewInnovatorAward #DP2 #NIH #HighRiskHighReward #Neurodegeneration #Organoids #AIGenomics #PrecisionMedicine
Stanton Lab | https://t.co/fxZPMol5uH

[Alice Stanton @AliceStanton]

function, predict therapeutic hypotheses, and accelerate the path from mechanism to intervention.

I am grateful to the @NIH_CommonFund, @NINDSfunding, and the High-Risk, High-Reward Research program for backing early-stage investigators with unusually ambitious ideas... 4/n

[Alice Stanton @AliceStanton]

at the speed and scale that discovery now requires.

This award lets us bring those pieces together: patient-derived, bioengineered organoid models that incorporate the major brain cell types and tissue architecture, coupled to AI-genomics approaches that can map variant... 3/n

[Brian S. Kim @itchdoctor]

1. More federal science funding should go directly to labs.

2. Science should be funded faster.

3. Scientists that convert federal funding to products (diagnostics, devices, and drugs) should be rewarded with more and faster #1 and #2.

This alone would exponentially change outcomes for our patients.

Currently, this is disproportionately delegated to philanthropic foundations.

[Anshul Kundaje @anshulkundaje]

Great stuff. We need so much more of this kind of critical introspection. This kind of work actually helps drive science onward & upward faster. Less hype, more of this kind of real science.

[Hans Clevers @HansClevers]

Organoid researchers!! Save the date for the annual "Organoids are Us"-symposium. Held at the Beatrix Theater in the center of beautiful historic Utrecht. Venue is a 20 minute train ride from Schiphol Airport Amsterdam. Program will follow shortly.

[Anshul Kundaje @anshulkundaje]

I am really digging this kind of frank presentation of very impressive results from a startup. More of this please. Budding scientists take note. You can do impressive stuff while highlighting important caveats. It creates more trust.