The Allegretti Lab

Clinical and translational research lab focusing on C. difficile infection and inflammatory bowel diseases lead by Dr. Jessica Allegretti @DrJessicaA

[Rahul S. Dalal, MD, MPH @RahulSDalalMD]

Our @BrighamGI @AllegrettiLab study comparing 1-year effectiveness of tofa vs uste for #UC is out in @IBDJournals:
https://t.co/3WBeLqCmSX

🔑After adjusting for confounders, no difference in steroid-free remission at 12 or 52 wks

🔑Similar drug survival during follow-up

[HCPLive @HCPLiveNews]

Higher steroid free remission on ups than on uste in a real word cohort per @RahulSDalalMD @EdBarnesMD @DrJessicaA

[Rahul S. Dalal, MD, MPH @RahulSDalalMD]

Thank you @DrAllegrettiIBD!

Some 🔑 pts:

⭐️Tramadol a/w ⬇️ odds of infection, SBO, and mortality vs traditional opioids in IBD, though there may be residual confounding.

⭐️Rx these cautiously and only when necessary! Treat the IBD.

⭐️ More 🔬 is needed comparing analgesics.

[Jessica R Allegretti, MD, MPH, FACG, AGAF @DrAllegrettiIBD]

Check out our data on utilizing colonic washes to identify c.difficile colonization in #IBD patients undergoing colonoscopy @AllegrettiLab #DDW2023

[Jessica R Allegretti, MD, MPH, FACG, AGAF @DrAllegrettiIBD]

@AllegrettiLab super star @RahulSDalalMD presenting data on real world outcomes of comparative effectiveness for #IBD therapies. #DDW2023

[Brigham and Women's GI @BrighamGI]

Congratulations to our 1️⃣4️⃣ faculty named Top Doctors 2023 by @BostonMagazine! #TopDocs⚕️

Thank you to our dedicated #BrighamGIFaculty for their passion & commitment to providing top-notch & cutting-edge care in digestive & liver health to our patients🩺

https://t.co/175LRy62T7

[Brigham and Women's GI @BrighamGI]

Congratulations to our Medical Director of Crohn's and Colitis Center & Director of Clinical Research Dr. Jessica Allegretti (@DrJessicaA) for her #promotion to Associate Professor at Harvard Medical School @harvardmed 🎉

#BWHIBD #BrighamGIFaculty #BrighamGIAlum @AllegrettiLab

[The Allegretti Lab @AllegrettiLab]

@DrJessicaA @RahulSDalalMD @BrighamGI Congrats @RahulSDalalMD !

[Jasmohan Bajaj @JasmohanBajaj]

Our RCT➡️⬇️#alcohol drinking post #FMT in #cirrhosis https://t.co/YajxyUoLHJ
Question
Are #microbiota enough for this ? YES!
Stools, but🚫supernatants from pts post #FMT ⬇️drinking in GF mice thru #SCFA
⬆️#intestine RNAseq changes>>liver or brain
Read⤵️
https://t.co/9wo9BnrFlx

[Dana Lukin MD, PhD @Dana_Lukin]

@BrighamGI @DrJessicaA @BrighamWomens @ShermanPrize @AllegrettiLab @harvardmed @CrohnsColitisFn Congrats, Jess!

[Jessica R Allegretti @DrJessicaA]

So thrilled our data on the potential role of BAs as novel #biomarkers for #CDI recurrence is out! Thank you @AmCollegeGastro for funding this work. And big thanks to @bhmullish and @imperialcollege for getting us to the finish line! https://t.co/FV2p1ZOWeA

[Jessica R Allegretti @DrJessicaA]

Join Us! BWH is accepting applications for 2023-24 Advanced IBD Fellowship. 1-year, comprehensive training program and includes opportunities for coursework at the Harvard School of Public Health. Direct inquiries to PD Matthew Hamilton MD [email protected]. Q's ⬇️

[Brigham and Women's GI @BrighamGI]

Study from #BrighamIBDFellow @RahulSDalalMD @AllegrettiLab on long-term outcomes after #ustekinumab dose⬆️ for #IBD

🔑>50% in corticosteroid-free remission (CFCR) after 12mo
🔑≥40% in CFCR after 24mo
🔑43% CD & 55% UC pts in endo remission

@IBDJournals: https://t.co/ixHsUHyIGQ

[Rahul S. Dalal, MD, MPH @RahulSDalalMD]

Data re: #tofacitinib for #pouchitis and related disorders are lacking. We @AllegrettiLab @BrighamGI published our single center experience in @IBDJournals :

Tofacitinib for the Treatment of Pouch-Related Disorders: A Case Series https://t.co/QPyEkk3lx2

[Parakkal Deepak MD, MS, FACG @P_DeepakIBDMD]

@AllegrettiLab @PDulaiMD @CSTseMD #AdamChiefetz #KostasPapamichael @DrPhil_Gu @GIDocAnnie @jensemineriomd @AmyLightnerMD @IBDMD @RishikaChughMD @JillGaidosMD @SimonHongMD @ps46bronx @JHashashMD @FarrayeIBD #JoelRoshMD

[Brigham and Women's GI @BrighamGI]

Congratulations to 3rd-yr #BrighamGIFellow @RahulSDalalMD on graduating w/ his Master of Public Health degree from @HarvardChanSPH 👨‍🎓🎉🎓

We are so proud of you & look forward to your continued success as a clinical investigator!

#HarvardChan22 #Harvard22 #MDMPH @AllegrettiLab

[Anita Afzali MD, MPH, MHCM, FACG, AGAF @IBD_Afzali]

It was a great meet up with friends
@EdwardLoftus2 @IBD_Houston @tinahamd @DrJessicaA at #DDW2022
@AmerGastroAssn @DDWMeeting

[Rahul S. Dalal, MD, MPH @RahulSDalalMD]

@DrJessicaA of @BrighamGI discusses her trial of an oral #microbiome therapeutic that effectively reduces recurrent #Cdiff @DDWMeeting #DDW2022 @AllegrettiLab

[The Allegretti Lab @AllegrettiLab]

@ACG Eastern Regional meeting chaired by @DrJessicaA and Dr. Sita Chokhavatia off to a great start. Lots of great #womeninGI representation

[ACG @AmCollegeGastro]

EBGI: Infliximab Therapy Is Associated w/ Reduced Antibody Responses Against SARS-CoV-2
Reviewers: Dr. Rahul Dalal & Dr. Jessica Allegretti

🟣 Read: https://t.co/kOdOaePdlH

@DrJessicaA @JenKolbMD @KumarShria @PhilipOkaforMD @spaulliver @JosephHabibi_MD @swatigp @RahulSDalalMD