Dogus Altintas

IFOM, Comoglio Lab

[Dogus Altintas @AltintasDogus]

Today @Fondaz_Veronesi awarded me a research grant to pursue my work on how cancer cells rewire protein synthesis to promote survival, progression, and therapy resistance.
This support will allow me to explore how non-coding alterations shape disease evolution.

[Colossal Biosciences® @colossal]

Meet Romulus and Remus—the first animals ever resurrected from extinction. The dire wolf, lost to history over 10,000 years ago, has returned. Reborn on October 1, 2024, these remarkable pups were brought back to life using ancient DNA extracted from fossilized remains.

Watch the pups grow up and catch exclusive videos on our YouTube channel. https://t.co/dmlOYtkZ4R

[The EMBO Journal @embojournal]

In issue 4:
FAM134B isoforms control ER dynamics in myogenesis
Bacterial virulence factor targets both neutrophils & complement system
Special pericytes in pulmonary capillaries
Cover: 1st plant spliceosome structure by Yichen Lu, Ke Liang & Xiechao Zhan
https://t.co/a5HDeLoicb

[The EMBO Journal @embojournal]

Translation re-initiation at uORFs by noncanonical translation factors MCTS1-DENR does not require their homolog eIF2D, but can be aided by MCTS2 as new DENR partner
David Gatfield and collaborators
https://t.co/sbdO1NIn2e

[The EMBO Journal @embojournal]

The integrated stress response drives MET oncogene overexpression in cancers
Dogus Altintas @AltintasDogus, Paolo Comoglio et al
https://t.co/jNnqZie5Yq

[Dogus Altintas @AltintasDogus]

Our new study in The EMBO Journal reveals how the Integrated Stress Response (ISR) drives MET oncogene overexpression in cancers. This breakthrough uncovers a key link between stress adaptation and cancer progression.
🧬 Read more: https://t.co/vBkCIkoCwB

[Dogus Altintas @AltintasDogus]

Today @fondazioneumbertoveronesi awarded me a research grant to pursue my work on the interplay between integrated stress response and invasive growth. I am thrilled to be with my daughter and my beloved wife for this important moment organised by Fondazione Veronesi.

[Dogus Altintas @AltintasDogus]

Thanks to the @Fondaz_Veronesi for supporting our research. We will keep doing our best to uncover mechanisms behind resistance to targeted therapies. @Comogliogroup

[Mary Elizabeth @meharpist]

One of my favorite @nature covers for this week’s issue

[Dogus Altintas @AltintasDogus]

Such a pleasure to start the day with such an e-mail. Better ones are coming soon...

[Dogus Altintas @AltintasDogus]

Very happy to publish the molecular mechanism of the rebound effect to MET-targeted therapy in cancer! @IFOMresearch @AIRC_it @Fondaz_Veronesi @Comogliogroup

[Dogus Altintas @AltintasDogus]

The PSI Domain of the MET Oncogene Encodes a Functional Disulfide Isomerase Essential for the Maturation of the Receptor Precursor https://t.co/KxRWMZZPRN #mdpiijms via @IJMS_MDPI

[Dogus Altintas @AltintasDogus]

A new MET functional domain @ResearchGate: https://t.co/Vo5TkMnuFw

[Dogus Altintas @AltintasDogus]

Did you think that MET oncogene was only a tyrosine kinase? Check out our new research paper revealing an unsuspected enzymatic activity of the receptor. Online soon at the special issue of IJMS... @IFOMresearch @AIRC_it @fpoirccs

[Dogus Altintas @AltintasDogus]

@GDarmanin Un visage rasé et un costume auraient été plus appropriés. Le ministère n’est pas un start-up!

[Dogus Altintas @AltintasDogus]

@DaddyMI5 @brault_helene The tweet is in English and perfectly describes the position. The French part describes how to apply, ie cover letter and CV, like all academic positions worldwide.

[LifeScienceAlliance @LSAjournal]

Mutated MET∆14 kinase is not constitutively active but requires HGF. The response to the ligand is stronger and long-lasting, protecting cancer cells from apoptosis and driving invasive growth. @IFOMresearch @AltintasDogus @Comogliogroup @airc_it

https://t.co/hASW2cI30T

[LifeScienceAlliance @LSAjournal]

MET∆14 promotes a ligand-dependent, AKT-driven invasive growth. By Altintas & Comoglio et al. @IFOMresearch @AltintasDogus @Comogliogroup

https://t.co/u17kAO1mbO

[Dogus Altintas @AltintasDogus]

MET∆14 promotes a ligand-dependent, AKT-driven invasive growth. https://t.co/TrQkZq9GTR @LSAjournal @IFOMresearch @Comogliogroup