Amanda Huff

Cancer immunotherapy researcher at Johns Hopkins

[Anirban Maitra @Aiims1742]

Congratulations @NeehaZaidi @DanielHaldarMD @DrLizJaffee and team! This is the 1st study to demonstrate the feasibility of mutant KRAS targeted vaccine - not in established #PancreaticCancer - but in HIGH RISK individuals, with persistent T cells ~2years!
https://t.co/ggsZsQUIFu

[Mark Yarchoan @MarkYarchoan]

Our lab is looking for a laboratory technician to work on a next generation cancer vaccine. Come join our great group! Link to apply:
https://t.co/dJT0Uy5mfM
@NeehaZaidi @DrLizJaffee @AmandaHuffPhD

[Nature Medicine @NatureMedicine]

A large, publicly available dataset integrating RNA, whole-exome, T cell receptor and 16S rRNA sequencing from patients with #ColonCancer enables the discovery of a #PrognosticScore consisting of tumor, immune and microbial features. #Microbiome #Tcell https://t.co/wAFGqIs1Mr

[The New York Times @nytimes]

Breaking News: A pancreatic cancer vaccine provoked an immune response in half of the patients treated in a small trial, a finding that experts described as very promising. https://t.co/Ofdbh8dsdM

[Amanda Huff @AmandaHuffPhD]

Excited to share our @NatureNV on a promising personalized neoantigen vaccine for pancreatic cancer!

[Nature News & Views @NatureNV]

Vaccine boosts T cells that target pancreatic tumours. Read about this clinical trial in a super N&V by @AmandaHuffPhD & @NeehaZaidi https://t.co/zDlgJketuf

[Nature Medicine @NatureMedicine]

A #DeepLearning algorithm using electronic health records from two large cohorts of patients predicts the risk of #PancreaticCancer from pre-cancer disease trajectories up to 3 years in advance, w/ promising performance. https://t.co/PFi0BmUqjO @sandercbio @TheBrunakLab

[Ton Schumacher Lab @Schumacher_lab]

Excited to share STAPLER, a language model to predict TCR – pMHC reactivity that outperforms prior models.

And for ML aficionados: Description of a new data leakage problem inherent to a common negative data generation strategy.

https://t.co/dsLeYJoT7v
🧵👇

[Nature Immunology @NatImmunol]

Rudensky and colleagues find that Treg depletion in a PD-1 resistant cancer model vastly alters the TME and Treg dependent programs were identified, such as the VEGF pathway. Treg depletion and VEGF blockade improved tumor control https://t.co/I7VMfs4kQJ

https://t.co/pAz8yNEAbd

[nature @Nature]

Learning the metabolic language of cancer https://t.co/k1k6BQWoni

[Science Translational Medicine @ScienceTM]

The @Immunologia1 lab links the immune-suppressing capabilities of #PancreaticTumors to #NeutrophilExtracellularTraps and their cleavage of the ARG1 enzyme—and show an anti-ARG1 antibody potentiates #immunotherapy and extends survival in mice. @UniVerona https://t.co/JUG8r6Hw6E

[Nature Medicine @NatureMedicine]

Neoadjuvant #nivolumab, #ipilimumab and chemotherapy showed promising efficacy for resectable #NSCLC, with higher tumor immune cell infiltration and tertiary lymphoid structures post-treatment compared to nivolumab plus chemotherapy @MDAndersonNews
https://t.co/V5Kq4vEf3p

[Nature Medicine @NatureMedicine]

A #machinelearning model that utilizes longitudinal #ctDNA metrics robustly predicts survival in two phase 3 trials of patients with metastatic #NSCLC, which may improve therapy selection and risk stratification. @genentech
https://t.co/maVoyEEyiV

[Christopher B Driscoll @C_B_Driscoll]

Exciting paper published in @NatureComms from our lab @RVilePhD @MayoClinic check it out! https://t.co/xMuaAfZDKN