Chris Sander aka cscbio

Do science that is predictive and use it to improve lives.

[Chris Sander aka cscbio @sandercbio]

Postdocs: Sander Lab, Systems Biology, Harvard Medical School. Data Science / AI / CompBio. Solve challenging biological problems.  (1) Catch cancer early using AI #CancerRiskNet #ovariancancer https://t.co/8ymjGpEyxA - Apply to sander.research (gmail) Subj: postdoc application

[Chris Sander aka cscbio @sandercbio]

End-to-end protein design for a broad scientific audience at https://t.co/YhCALRbFfD - try it !

[Debora Marks @deboramarks]

Meet evedesign: a new open-source ML framework that makes protein design accessible and interoperable.

📢 See our post: https://t.co/lK3Szb3ff8

Protein design models are powerful, but combining them shouldn’t require custom glue code.

✅Combine models for multi-objective optimization
✅Integrate lab-in-the-loop experimental of data
✅100% secure: run on your own infra, no data sharing

Get started building therapeutics & industrial enzymes today 👇
📄Paper: https://t.co/eTOTY6kfZ0
💻Code: https://t.co/Hn3zatn5nc
🌐Webserver: https://t.co/cAM8NVMbL4

Reach out to collaborate: [email protected]

[Debora Marks @deboramarks]

Announcing our new protein design server https://t.co/nHeMlJVba2:
• End-to-end protein design for everyone!
• Analyze your generated library interactively and on 3D structures
• Export codon-optimized DNA sequences for experimental testing.
Developed in collaboration between @deboramarks, @thomas_a_hopf, @SteineggerM, Simon d'Oelsnitz, Chris Sander, Artem Gazizov,@haysunny_hi, Milot Mirdita, Sergio Garcia Busto, Jake Reardon

[Chris Sander aka cscbio @sandercbio]

Protein design with almost-AI -- evolution does it

[Diego del Alamo @DdelAlamo]

"Simultaneous enhancement of multiple functional properties using evolution-informed protein design"

Novel b-lactamases designed w/ EVCouplings; "functional designs had large increases in thermostability and most had a broadening of available substrates"

https://t.co/d7xgJUECDa

[Chris Sander aka cscbio @sandercbio]

Read and think !

[Gary Bader @garybader1]

Happy to be part of the process to develop AI recommendations for UofT. I encourage everyone interested in AI policy to read the report.

[Chris Sander aka cscbio @sandercbio]

Things get better in science over time with good starting ideas and subsequent hard work. 2016 Evolutionary Couplings for RNA folding. 2025 Comprehensive RNA benchmark and tool comparison for everyone in the biomolecular AI field. Great team work with MarksLab!

[Debora Marks @deboramarks]

RNA, RNA, RNA

https://t.co/ewmhRgrGGa

Been a long time goal of @deboramarks.bsky.social to help RNA sequence —> function mapping a million years ago we tried
https://t.co/HiX8fojhNx

Now total refresh for our new world, led by Rohit Arora and Murphy Angelo for seeing this thru and Pascal Notin for pulling together!!!

[Debora Marks @deboramarks]

How can we use #GenerativeAI for #ProteinDesign? - check out work from our labs @deboramarks and @yaringal
https://t.co/mPxqX5TWxd

[Chris Sander aka cscbio @sandercbio]

@the_tessallator For the analysis and design of perturbation biology experiments - use it and add to it! Toward computational models of *all* of cell biology.

[Nature Biotechnology @NatureBiotech]

The February issue, with a focus on protein engineering, is live https://t.co/5zL1A8zf3S

Our cover shows the three data types key to machine learning for functional protein design: structure, sequence and labels, from a Review by Notin et al. https://t.co/ZgfK6N0LD7

[Chris Sander aka cscbio @sandercbio]

A first step toward designing combo anticipatory vaccines !

[Sarah Gurev @sarahgurev]

Previous viral evolution can shed light on future immune evasion. EVEscape, now out in @Nature, is our first step in applying pre-pandemic data to forecast antibody escape through the course of a pandemic. https://t.co/9jE1oaAX6T 🧵1/6

[B. Arman Aksoy @armish]

Looks like I was able to re-purpose ChatGPT's new function return support to enrich answers about human genes using the most up-to-date @genenames data.

This still has too much boilerplate stuff in it but here is the full notebook for the curious: https://t.co/dQFXaafqvh

[Chris Sander aka cscbio @sandercbio]

Postdocs: Sander Lab, Systems Biology, Harvard Medical School. Data Science, AI, CompBio. Solve challenging biological problems. (2) Develop large-scale models of cell biology https://t.co/3YHpBWW3ao https://bit/ly/CellBox
Apply: sander.research (gmail) Subj: postdoc application

[Chris Sander aka cscbio @sandercbio]

More to come in international open collaboration #CancerRiskNet aka #BianQue << Solve Bo Yuan’s puzzle.

[Bo Yuan @boyuan_data]

(1/6) Very excited to share our work on @NatureMedicine using #AI to predict #cancer with disease history only (no CT scan!). Glad to co-lead the work with @davplacido @jessicaxhu Chunlei Zheng @sandercbio @TheBrunakLab and many more great colleagues https://t.co/vEY2eOUN4A .

[Davide Placido @davplacido]

AI Predicts Future Pancreatic Cancer https://t.co/3dLBGQnNkY

[Chris Sander aka cscbio @sandercbio]

Risk of pancreatic cancer predicted using machine learning. International collaboration. @TheBrunakLab @DanaFarber_Hale @harvardmed @HMS_SysBio @GENES_PK @Nrfillmore @boyuan_data @davplacido @deboramarks @sandercbio https://t.co/7hUonsEeUG https://t.co/dpxdPfc8Ky

[Institute for Protein Design @UWproteindesign]

Ready to learn about protein design? Our beginner's guide breaks down this complex field into easy-to-understand concepts. Discover the potential of proteins to transform our world: https://t.co/OGrrvh0BnR

[Chris Sander aka cscbio @sandercbio]

Go cBioPortal ! Lots of new features for easy analytic access to cancer genomics, proteomics and more. Make your own discoveries on community-provided cancer data and analysis tools.

[cBioPortal @cbioportal]

Come learn about cBioPortal at #AACR2023: Talks on Saturday by @NikolausSchultz at 8:30 AM in Room W224 (#NCIITCR session) as well as by Tali Mazor in Room W311 at 8:45 AM (@AACR Project GENIE session), a poster on Tuesday morning, and a booth in the exhibitor space (#1943).

[Chris Sander aka cscbio @sandercbio]

Wish one could weigh in with NNF to reverse this decision. Very hard to understand. Our collaborations with CPR labs Mann and Brunak have been singularly successful. Great science & scientists.

[Matthias Mann Lab @labs_mann]

Tremendously sad day for Danish science as Novo Nordisk Foundation is closing its flagship protein research institute, arguably the best in the world. @UCPH_CPR has been a beacon of science and progress for years. Let's cherish the remaining years & strive to continue the legacy.

[Pascal Notin @NotinPascal]

Very pleased to announce that our paper “Tranception: protein fitness prediction with autoregressive transformers and inference-time retrieval” was accepted at ICML!
Paper: https://t.co/tgpUs90sLz
Repo: https://t.co/XHCNwcPL26
(1/10)

[Debora Marks @deboramarks]

https://t.co/qCCSe23b6O is recruiting an Associate Lab Director! An outstanding opportunity for an ambitious computational biologist to manage projects at the cutting edge of machine learning and genomics. Send CV to [email protected]