Amany Said FRCPATH, PhD

Mother, Wife, love walks especially challenging ones, Histopathologist in Lancashire teaching hospitals, United Kingdom

[Jonathan Zuckerman MD PhD @JZRenalPath]

Diabetic with acute kidney injury, 16 g proteinuria, hematuria. Nodular diabetic nephropathy, yes, but endocap PMNs, C3 dominant and IgA deposits, hump-like sub epithelial deposits on EM and seen on trichrome. --> Superimposed infection related GN. #renalpath #nephropath

[Arkana Laboratories @arkanalabs]

The arrow points to an intranuclear viral inclusion characteristic of BK virus, one species of non-enveloped dsDNA viruses belonging to the polyoma virus family. Sarah Stewart (see inset), a physician and research scientist, studied viral oncogenesis (she was the first woman to earn an M.D. degree from Georgetown Medical School). Dr. Stewart and her collaborator, Dr. Bernice Eddy (Ph.D. virologist), renamed the parotid tumor virus originally discovered by Ludwik Gross “SE polyoma virus” (the “SE” was for “Stewart-Eddy”). Interestingly, Dr. Stewart like the name “omnioma” virus, but Eddy suggested the term “polyoma” virus since not all viral infections caused tumors in all tested animals. The detailed history of this virus family and its discoverers is chronicled in a fascinating article by Gregory J. Morgan (see below).

References
Morgan GJ. Ludwik Gross, Sarah Stewart, and the 1950s discoveries of Gross murine leukemia virus and polyoma virus. Stud Hist Philos Biol Biomed Sci. 2014 Dec;48 Pt B:200-9. PMID: 25223721.

Photograph of Dr. Sarah Stewart, 1971. Public domain (National Library of Medicine)

#TeachingPoints #kidneypath #renal #pathology

[Arkana Laboratories @arkanalabs]

A sample from the pathology teaching slide set on Immunoglobulin- and Complement-mediated Glomerular Diseases with an MPGN Pattern of Injury, jointly prepared by Arkana Laboratories and @goKDIGO. https://t.co/KwXMfV3nTh

#KDIGO #pathology #renal #kidneypath

[Amany Said FRCPATH, PhD @AmanysaidP]

@arkanalabs Cryoglobulinaemic GN

[Amany Said FRCPATH, PhD @AmanysaidP]

@arkanalabs Immunotactoid GN

[Jonathan Zuckerman MD PhD @JZRenalPath]

Pt with SLE and sjogren with hematuria and proteinuria. +++RF, low C3/C4, IgM-k MGUS. Biopsy revealed IgM-k dominant GN with cryo plugs + vasculitis + abundant pure microtubular deposits c/w cryoGN. Some deposits being engulfed by macrophages. #renalpath #pathtwitter #nephrology

[Arkana Laboratories @arkanalabs]

The photomicrograph shows a distended tubule with an intratubular crystalline cast with agryophilia. While crystalline casts can be seen from calcium phosphate, calcium oxalate and others, the presence of agryophilia on sliver stain is characteristic for 2,8-Dihydroxyadenuria (DHA) crystals. 2,8-DHA is a rare, autosomal recessive trait caused by a genetic deficiency in adenine phosphoribosyltransferase (APRT). Accurate diagnosis is critical (especially in those with limited chronicity) as treatment exists that can ameliorate renal damage in some patients. And, in patients with undiagnosed disease who undergo transplant, the disease will reoccur unless pharmacologic intervention is initiated. Of note, agryophilic, birefringent crystals can also be seen in patients exposed to triamterene which should always be excluded before a diagnosis of 2,8-DHA is rendered.

#renalpath #kidneypath #pathology #renal #pathtwitter

[Elizabeth Montgomery, MD @LizMontgomeryMD]

These samples are from a patient known to have Behcet disease. It is a vasculitis that can affect both small and large blood vessels, usually veins.

[Arkana Laboratories @arkanalabs]

What is your diagnosis?

#DiagnoseThis #nephtwitter #pathtwitter #renal #kidneypath

[Elizabeth Montgomery, MD @LizMontgomeryMD]

Extra-uterine endometrial stromal sarcoma has a knack for mimicking synovial sarcoma. The staghorn vessels and overlapping nuclei always send me down the wrong path at first but the collagen saves the day! Yay - Phew.

[Amany Said FRCPATH, PhD @AmanysaidP]

@TingZhaoPathdoc Thank you for the update 😊

[Manasi Trivedi @Manasi_Trivedi]

#pulmonarypath #crittersonX #pathquiz #pathx
Hemoptysis with cavitary lesion
Guess the culprit!

[Ting Zhao, MD @TingZhaoPathdoc]

60s M, distal urethra. Diagnosis?
#PathTwitter
@MGBpathology @MGHPathology

[Jerad Gardner, MD @JMGardnerMD]

Skin colored bump on nose. Diagnosis?
Answer ✅ https://t.co/2tocRjwlXs
(pic with trichrome stain just because it's so gorgeous!) 😍
#pathology #pathologists #pathTwitter #dermpath #dermatology #dermatologia #dermtwitter

[aung phyo @pathphyo]

A cute parathyoid incidentally found in right lobectomy specimen of thyroid done for multinodular goiter.
#pathology #endocrine #parathyroid

[Jerad Gardner, MD @JMGardnerMD]

I may be ugly, but at least I’m benign. What am I?
Answer ✅ https://t.co/wSmKPSwI6f
#pathology #pathologists #pathTwitter #dermpath #dermatology #dermatologia #dermtwitter

[Ting Zhao, MD @TingZhaoPathdoc]

50s M, testicular mass. Diagnosis? Gross photo in the chat.
#PathTwitter #PathX
@MGHPathology @MGBpathology

[Charlie Herndon @DrCycloPath]

52-year-old male presents with a painless, slow-growing subcutaneous mass on his shoulder.
A) Spindle cell lipoma
B) Dermatofibrosarcoma protuberans
C) Neurofibroma
D) Myxofibrosarcoma

#Pathology #PathQuiz 🔬#DermPath

[Manasi Trivedi @Manasi_Trivedi]

Last week I came across this beauty! #GIPath #PathTwitter #crittersonX #pathquiz. Duodenum is common site for this.
Guess my name!

[Charlie Herndon @DrCycloPath]

#PathQuiz 🔬#DermPath

A) Basal cell carcinoma
B) Spiradenoma
C) Sebaceoma
D) Merkel cell carcinoma
WSI https://t.co/yArVLu7wIo