Andrei Pisliakov

Computational Biophysics at Dundee University

[Andrei Pisliakov @AndreiPisliakov]

Our new paper on regulation of RNA Capping Enzyme by CTD of #RNA #Polymerase II is out in Nucleic Acids Research! Excellent work by PhD student @Marcus_Bage and great collaboration with Vicky Cowling’s lab @Vichaico.

biomolecular simulations; allostery

https://t.co/7YeqrQpFKr

[Rastko Sknepnek @sknepnek]

Please RT! Recruiting 4 postdocs to work on a collaborative project between Dundee, Oxford (@G_Charras) and UCL (@juliayeomans)
To apply:
Dundee: https://t.co/lCqAapSKEI and https://t.co/TlmLlzKjNu
Oxford: https://t.co/WKht4fhbSb
UCL: https://t.co/2P13zX5VOa

[Callum Ives @CallumMIves]

Our work from @UZDundee group on PorB is now available in @BBAjournals! This interdisciplinary collaboration utilises X-ray crystallography, electrophysiology & MD simulations to study porin-based drug-resistance in Gram-negative bacteria @UoDLifeSciences https://t.co/BQblwlalQj

[GRE Dundee @GREDundee]

Latest collaborative research from @AndreiPisliakov & @Vichaico has identified novel interaction sites on the mRNA Capping Enzyme that are essential for its activity. Work published in @NAR_Open with @Marcus_Bage first author 👏
https://t.co/1WIys7eqjo

[Open Research, University of Dundee @UoDOpenResearch]

🔓 #OpenAccess

A novel RNA Pol II CTD interaction site on the mRNA Capping Enzyme is essential for its allosteric activation

➡️https://t.co/rUtvKP0nkX

@UoDSciEng @UoDLifeSciences @GREDundee @Marcus_Bage Dr Almohammed @Vichaico @AndreiPisliakov
#RNA #Polymerase II

[Andrei Pisliakov @AndreiPisliakov]

Congrats to Marcus, Rajaei and Vicky! Extremely proud of this work! Huge thanks to agencies who supported this research! @The_MRC @PhysicsScotland @WellcomeTrust ISSF @UoDLifeSciences

[Andrei Pisliakov @AndreiPisliakov]

Our new paper on regulation of RNA Capping Enzyme by CTD of #RNA #Polymerase II is out in Nucleic Acids Research! Excellent work by PhD student @Marcus_Bage and great collaboration with Vicky Cowling’s lab @Vichaico.

biomolecular simulations; allostery

https://t.co/7YeqrQpFKr

[Andrei Pisliakov @AndreiPisliakov]

We also offer a new perspective on the evolutionary basis of this interaction and discuss palindromic nature of the CTD code, a previously overlooked feature. This will have implications for how other binding partners interact with the CTD, reading and writing the CTD code.

[Andrei Pisliakov @AndreiPisliakov]

@Marcus_Bage Congratulations Marcus! Huge effort and as a result a great paper.

[Andrei Pisliakov @AndreiPisliakov]

@Marcus_Bage @Vichaico Congratulations Marcus! Huge effort and as a result a great paper.

[Marcus Bage @Marcus_Bage]

Delighted to see my first first author paper online today! We use simulations to find RNA PolII CTD binding sites on the mRNA Capping Enzyme and uncover their vital role in allosteric activation. Of interest to anyone using MD to study PPIs and allostery! https://t.co/At9tijIsXq

[Дмитрий Навоша @navosha]

Мировые обложки сегодня – про исторический белорусский Марш Свободы

[Dominic Raab @DominicRaab]

The violence against peaceful protesters in Belarus is appalling. The UK does not accept the results of this fraudulent Presidential election & calls for an urgent investigation through @OSCE into its serious flaws & the grisly repression that followed. https://t.co/VPJ4yrTCXZ

[UoD Life Sciences @UoDLifeSciences]

A two-lane mechanism for selective biological ammonium transport is the latest collaborative work between @UZDundee & @ArnaudJavelle @UniStrathclyde. Published @eLife
Authors include @AndreiPisliakov @Marcus_Bage @CallumMIves @LabAmmonium
https://t.co/ZxQNFCJFtv

[Andy Biotech @AndyBiotech]

Excellent interview with Oxford #COVID19 vaccine project leader Professor Adrian Hill
https://t.co/kCyeHCPmHV

He warns against 'over-promising', as #coronavirus vaccine success is far from guaranteed

[Siewert-Jan Marrink @CG_Martini]

Simulation of the membranes of an entire mitochondrion !
See how more than 5 million lipids are organized in this amazingly complex organelle ...
https://t.co/J1x4kQnYm8

[Geoff Barton @gjbarton]

Our manuscript with @stuartmac44 @bartongrp @UoDLifeSciences identifies gnomAD and unobserved variants likely to enhance or inhibit SARS-CoV-2 binding and genetic risk in #COVID-19. Also discusses engineering ACE2 as a possible therapy. @biorxivpreprint https://t.co/917EGKKSBZ

[Andy Mesecar @andymesecar]

We just released to the world the 3D X-ray structure of #COVID-19 main protease bound to the FDA approved drug boceprevir (Victrelis). PDB Code 6WNP

[Jean-Philip Piquemal @jppiquem]

The @VTX_mol viewer is now operational and will enable large scale/real time visualization of eXtremely large systems #compchem