Stage II/III Melanoma Management — The 2026 Update 🧵
The management paradigm has shifted beyond surgery alone.
✅ Wide local excision with appropriate margins
✅ SLNB for T1b and above
✅ No routine completion lymph node dissection (MSLT-II)
✅ Adjuvant anti–PD-1 therapy for high-risk resected disease
✅ Dabrafenib + Trametinib for BRAF V600-mutant Stage III
✅ Neoadjuvant immunotherapy (NADINA, SWOG S1801) is redefining the standard for resectable macroscopic Stage III melanoma with response-adapted treatment.
A concise infographic summarizing current evidence, landmark trials, and exam pearls for oncology trainees.
#Melanoma #SkinCancer #MedicalOncology #Oncology #Immunotherapy #Neoadjuvant #Pembrolizumab #Nivolumab #Ipilimumab #BRAF #TargetedTherapy #Surgery #ESMO #ASCO #DrNB #DMMedicalOncology #MedEd #FOAMed #CancerEducation #OncologyTwitter #CancerConceptsExplained
Capecitabine + Oxaliplatin
Chemo Regimen
COLORECTAL cancers
Doses
Indications
Toxicity and Grading
Dose Reductions and Stopping Rules
A simple Glance for Oncologists in Clinics
The MONARCH Trials — The Complete Abemaciclib Story
From metastatic HR+/HER2− breast cancer to high-risk early breast cancer, HER2-positive disease, and CDK4/6 inhibitor continuation beyond progression, the MONARCH program has defined the clinical role of abemaciclib across the breast cancer continuum.
This infographic provides a one-glance visual summary of the key MONARCH trials and their major clinical take-home messages.
What trial from the MONARCH program has had the greatest impact on your clinical practice?
#BreastCancer #bcsm #Oncology #MedTwitter #Abemaciclib #CDK46 #MONARCH #MedicalEducation #MVOnco
A veces pienso que una de las mayores muestras de cariño es la curiosidad. Preguntar, escuchar, recordar detalles. Hay personas que dicen quererte y nunca han sentido interés por descubrir quién eres realmente.
How long do our landmark melanoma therapies keep patients alive?
A simple memory aid for the approximate median overall survival reported in pivotal trials:
1.5 → 2 → 3 → 4.5 → 6 years
• Ipilimumab
• Dabrafenib + Trametinib*
• Nivolumab
• Nivolumab + Relatlimab†
• Nivolumab + Ipilimumab
This is not a head-to-head comparison—each value comes from different pivotal trials with different patient populations and follow-up. It's simply a practical way to remember the magnitude of benefit achieved across the evolution of metastatic melanoma therapy.
*BRAF V600-mutant melanoma only.
†Approximate landmark OS from 5-year follow-up; mature median OS has not yet been formally reported.
Which number do you remember first: 1.5, 2, 3, 4.5, or 6?
#Melanoma #Oncology #MedTwitter #FOAMed #Immunotherapy #BRAF #MedicalOncology #MVOnco
EAU-EANM-ESTRO-ESUR-ISUP-SIOG Guidelines on Prostate Cancer-2026 Update. Part I
https://t.co/M2JsBqwAU7
EAU-EANM-ESTRO-ESUR-ISUP-SIOG Guidelines on Prostate Cancer. Part II-2026 Update
https://t.co/JNfephHD5E