The problem with new and unregulated technology is that people start doing things with no evidence. 12% of cohort had liver met from pancreas. 11% 30 day mortality. What are we doing?? Biology did not all of a sudden go away.
👇🏼👇🏼
@jamasurgery https://t.co/zaXpwcpnMs
“I was neither angry nor scared. It simply was. It was a fact about the world, like the distance from the sun to the Earth.” Revisit an excerpt from Paul Kalanithi’s posthumously published memoir about his battle with metastatic lung cancer, “When Breath Becomes Air”: https://t.co/GhgW1vcRFm
Neoadjuvant Chemotherapy With Gemcitabine and S-1 Versus Upfront Surgery for Resectable Pancreatic Cancer
Results of the Randomized Phase II/III Prep-02/JSAP05 Trial @AnnalsofSurgery
https://t.co/8weh6TPqOw
Wow, many issues w this 47-pt, sponsor-run, single-arm histotripsy study.
Short 🧵 1/4
1. Post-hoc imaging re-read: primary read w validated criteria showed 1-yr LC 63%, but they emphasize a post-hoc re-read (using new “experience” w histo imaging) bumping local control to 90%.
Courageous and great article from @MSKCancerCenter on Histotripsy published in @cvironco ! Link: https://t.co/ubMPOeRioK
“Patients arrive with predetermined expectations shaped by marketing rather than clinical reality, pressuring physicians
to offer treatments lacking comprehensive validation. Healthcare institutions acquire expensive systems to
remain competitive, even when clinical need may not justify the investment. Resources are diverted toward technologies with limited proven benefit, while established treatments receive diminished attention.”
“Aggressive promotion, driven by commercial interests and capital market pressures, presents theoretical benefits as established advantages. Current histotripsy studies remain predominantly single-center experiences with
limited follow-up. The technology’s purported immunologic effects remain entirely theoretical, yet marketing
materials present these claims with inappropriate certainty. Patients seek "non-invasive" treatments based on promotional materials overstating capabilities while minimising limitations. This marketing-first approach raises
ethical concerns about informed consent and resource allocation.”
Researchers at @MSKCancerCenter examined longitudinal scans from patients under surveillance for intraductal papillary mucinous neoplasms.
Learn more about their study, which used large language models (LLMs), in @acsJACS ⬇️ https://t.co/vaLk5VjqZB
Pancreatic cyst diameter alone is not strongly predictive of dysplasia and can be safely monitored with low rate of progression during surveillance.
https://t.co/8qh7wm9rwz
The @UofTSurgery community mourns the loss of cherished colleague, Dr. Sean Cleary. "Sean has touched the lives of many of us – as a clinical colleague, teacher, mentor, supervisor, confidential advisor, and friend. . ."
Read the Chair's message at https://t.co/oS8FnBkV9C
How can you selectively block an oncogenic transcription factor? We found that reactivating the epigenetic repressor ezh2 does the job against mutant b-catenin. Mechanism uncovered with a new KI that we developed and named WNTinib. Check out the paper @NatureCancer
Pleased to share another publication in our series examining the diversity and leadership in #surgery Published in the @SESC_AmSurg special issue on #DEI and #leadership@rwjsurgery
https://t.co/xApll9IyIz
Delighted to share our work on preemptive renal transplantation and optimal GFR range for improved patient outcomes @rwjsurgery
https://t.co/bXAPtK1oQw
For those that follow my instrument posts, I may now announce there will be an ongoing series in BJS (British Journal of Surgery) called The Instrumentalist.
The first entry in the series is on scalpel handles and blades. Access is free, and is here:
https://t.co/HqsDXUXvDH
How cool is this ? Craft beer dedicated to celebrate us, by master brewer, surgeon extraordinaire and our Chief Surgical Officer at @RutgersCancer@RichardalexMD. This one dedicated to our very own Dr David August! @rwjsurgery