Appaso Jadhav

Staff Scientist @ Scripps Research Department of Chemistry and Chemical Biology

[Chris Parker @_chrisgparker_]

Happy to share a new preprint from our group in collaboration with AbbVie led by graduate student ⁦@InesForrest⁩ . https://t.co/FvVPYycegj

[Chris Parker @_chrisgparker_]

Happy to share new work led by recent grad @AnnyChe77788549 and @SinghaSoumya. Here, we expanded our AceTAG platform to include PCAF/GCN5 & used this toolbox to investigate functional consequences of targeted p53 acetylation. w/@Michael_A_Erb. @ACSBioMed https://t.co/YuEf3D8PAE

[Chris Parker @_chrisgparker_]

Excited to share the final version in
@nchembio. Lots more mechanistic insights & characterization, including our inhibitors disrupt PPIs with mTOR components & induce lysosomal degradation of SLC15A4, & more. A promising target for autoimmune conditions. https://t.co/9qZLh7hRo8

[Chris Parker @_chrisgparker_]

https://t.co/8CjwrKRNkQ Delighted to share our recent work. We developed an enhanced chemoproteomic workflow to determine PAL probe interaction sites in cells, enabling ID of diverse binding pockets, providing evidence of their chemical tractability & more w/@ForliLab & @bmsnews

[Chris Parker @_chrisgparker_]

Excited for this @scripps Chem collaborative work out in @Nature w/@BaranLabReads & Lairson Lab. Has a bit of something for everyone…herculean total synthesis, structural reassignment, chemoproteomics, new druggable target, in-depth functional characterization & more

[Chris Parker @_chrisgparker_]

Check out our review on Proteome-wide Fragment-Based Ligand and Target Discovery in the 2022 Wolf Prize special issue of Isr J Chem. Led by ⁦@InesForrest⁩! https://t.co/TeFoKbPKHk

[Chris Parker @_chrisgparker_]

Big congrats to Junchen and @BaranLabReads on this feat! Excited to be able to contribute w/@WChembio to this story. A great example of how enabling total synthesis can be to reveal new and exciting biology.

[Chris Parker @_chrisgparker_]

Happy to share our (w/ @Teijaro_Lab) integrated chemoprotoemic approach to develop functional inhibitors of SLC15A4 - a challenging target that controls some exciting biology

[Matt Pratt @MattRPratt]

@MichaelNADbio I would add this paper from Ben Cravatt’s lab. It figures out the first set of conditions to get CuAAC to work well in cell lysates, one of the most powerful applications: https://t.co/eScsQM6FxF. Brings me back to the days of having to make my own TBTA ligand from scratch.

[The Nobel Prize @NobelPrize]

BREAKING NEWS:
The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”

[J. Am. Chem. Soc. @J_A_C_S]

A Chemical Proteomic Map of Heme–Protein Interactions @scrippsresearch #Proteomics 3Mapping #Heme #Proteins #Interactions https://t.co/7fm69wtmQl

[Chris Parker @_chrisgparker_]

Shining some light on an old molecule. Rick (@RickHoman4) developed a heme-based photoaffinity probe and mapped its targets across the human proteome, leading to some interesting findings. Congrats Rick and team!

https://t.co/PiD5bvW4Tl

[Chris Parker @_chrisgparker_]

The final version of this work is now out in @J_A_C_S. A big congrats to Wesley, Anny and team!
https://t.co/5Bfj0GmGKv

[하은 @RickHoman4]

Very proud and thankful to have had the opportunity to co-first author this paper with my exceptionally talented lab mates. Congrats to my PI Chris, Post docs Louis and Appaso, and the rest of the team involved in the Parker lab and at BMS! First grad publication in the books.

[Chris Parker @_chrisgparker_]

Check out our recent work in collaboration w/ @bmsnews evaluating different fully functionalized diazirine tags for chemoproteomic studies. Turns out, tag choice has a big impact on what you “see” by MS. We also developed a new terminal diazirine tag
https://t.co/qeLXkYAQga

[Chris Parker @_chrisgparker_]

Happy to share our review and perspectives on drugging SLC transporters. A big congrats to first author Wesley and team. Thanks @JMedChem for the opportunity! https://t.co/RRILQ8RJLR