Enjoyed reviewing and summarizing this important & reproducible (yes we tried it) paper on how DMSO is sufficient to induce human balstoids from human naive PSCs, emphasizing (again) the great importance cell state has on embryo models formed. Congrat to Mo Li group & @KAUST https://t.co/Rgn0aJrCVD
Thrilled that our paper is the cover story & featured paper in July issue of @cell_res!
We reveal a simple DMSO-based approach to human blastoid formation and uncover roles for lysosomal acidification and cellular biophysics
@KAUST_News@KAUST_BESE
https://t.co/i6AnE6d75A
New in @NatureComms simple 5′Cy5 modification of ssODN donors boosts CRISPR–Cas9 HDR, improves survival, and enables precise editing in human organoids and blastoids, reaching 30% sickle cell mutation correction
@KAUST_News@KAUST_BESE@KAUST_PSE@ShmsLab https://t.co/Iw3iDEKVWt
We developed a simple DMSO-based human blastoid model recapitulating key pre- and post-implantation features and uncovered an essential role for V-ATPase-mediated lysosomal acidification in mammalian blastocyst cavitation. https://t.co/3hQCpqIs86
#blastoids#embryomodel#kaust
Registration for KAUST Research Conference: EmbryoCon26, April 6–8, 2026 is now open!
Join leading scientists & clinicians in early development, feto‑maternal interaction, & reproductive medicine.
🔗 https://t.co/Lsw7LXubrp
📩 [email protected]#KAUST#EmbryoCon26#StemCells
Gene editing can reshape more than just DNA.
Mo Li and team found that CRISPR-Cas9 breaks trigger profound epigenetic changes, an overlooked complexity, underscoring the need to recognise these effects to improve safety and inform novel treatment options. https://t.co/2bZSYyBk6j
CRISPR–Cas9 DSBs don’t just change DNA sequence — they also disrupt DNA methylation. Using
@nanopore native long reads, our lab uncovered stable epigenetic side effects of DSB repair.
https://t.co/9WBSMzslVY
#KAUST#CRISPR#epigenetics
Our translational work out @MedCellPress We develop NanoRanger using @nanopore sequencing to diagnose Saudi genetic diseases Thx for the collab w/ @alkuraya @KFSHRC_Research https://t.co/77qvmcDxAD @KaustResearch https://t.co/4U4vZlbU1z
Sign up for Nature Briefing for a chance to win this adorable Nature mouse, tucked in its very own mouse-genome bag. The perfect accessory for the #LunarNewYear! https://t.co/O3p4etWG4V
University Grants Commission (UGC) has released a press notice to all Indian research scholars on academic integrity yesterday.
https://t.co/lBvYY243p0
#ugc#PhD#researchscholar#indiaphd#fakejournals